beta 2-Microglobulin

"beta 2-Microglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.

Descriptor ID	D001613
MeSH Number(s)	D12.776.124.790.223.100 D12.776.377.715.182.100
Concept/Terms	beta 2-Microglobulin beta 2-Microglobulin 2-Microglobulin, beta beta 2 Microglobulin Thymotaxin

Below are MeSH descriptors whose meaning is more general than "beta 2-Microglobulin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Serum Globulins [D12.776.124.790]
Beta-Globulins [D12.776.124.790.223]
beta 2-Microglobulin [D12.776.124.790.223.100]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Beta-Globulins [D12.776.377.715.182]
beta 2-Microglobulin [D12.776.377.715.182.100]

Below are MeSH descriptors whose meaning is related to "beta 2-Microglobulin".

Below are MeSH descriptors whose meaning is more specific than "beta 2-Microglobulin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta 2-Microglobulin" by people in this website by year, and whether "beta 2-Microglobulin" was a major or minor topic of these publications.

Bar chart showing 18 publications over 12 distinct years, with a maximum of 4 publications in 1999

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	1	1	2
1999	1	3	4
2002	0	1	1
2004	0	2	2
2005	2	0	2
2006	0	1	1
2007	0	1	1
2010	0	1	1
2015	0	1	1
2016	0	1	1
2021	1	0	1

Below are the most recent publications written about "beta 2-Microglobulin" by people in Profiles.

Samukawa S, Yoshimi R, Kirino Y, Nakajima H. The PRY/SPRY domain of pyrin/TRIM20 interacts with ?2-microglobulin to promote inflammasome formation. Sci Rep. 2021 12 08; 11(1):23613.

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Juraschek SP, Chang AR, Appel LJ, Anderson CA, Crews DC, Thomas L, Charleston J, Miller ER. Effect of glycemic index and carbohydrate intake on kidney function in healthy adults. BMC Nephrol. 2016 07 08; 17(1):70.

View in: PubMed
Morin-Brureau M, Hooper KM, Prosniak M, Sauma S, Harshyne LA, Andrews DW, Hooper DC. Enhancement of glioma-specific immunity in mice by "NOBEL", an insulin-like growth factor 1 receptor antisense oligodeoxynucleotide. Cancer Immunol Immunother. 2015 Apr; 64(4):447-57.

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Romaguera JE, Fayad LE, Feng L, Hartig K, Weaver P, Rodriguez MA, Hagemeister FB, Pro B, McLaughlin P, Younes A, Samaniego F, Goy A, Cabanillas F, Kantarjian H, Kwak L, Wang M. Ten-year follow-up after intense chemoimmunotherapy with Rituximab-HyperCVAD alternating with Rituximab-high dose methotrexate/cytarabine (R-MA) and without stem cell transplantation in patients with untreated aggressive mantle cell lymphoma. Br J Haematol. 2010 Jul; 150(2):200-8.

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Patel TB, Pequignot E, Parker SH, Leavitt MC, Greenberg HE, Kraft WK. Transgenic avian-derived recombinant human interferon-alpha2b (AVI-005) in healthy subjects: an open-label, single-dose, controlled study. Int J Clin Pharmacol Ther. 2007 Mar; 45(3):161-8.

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Fishelevich R, Malanina A, Luzina I, Atamas S, Smyth MJ, Porcelli SA, Gaspari AA. Ceramide-dependent regulation of human epidermal keratinocyte CD1d expression during terminal differentiation. J Immunol. 2006 Feb 15; 176(4):2590-9.

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Cheung AK, Rocco MV, Yan G, Leypoldt JK, Levin NW, Greene T, Agodoa L, Bailey J, Beck GJ, Clark W, Levey AS, Ornt DB, Schulman G, Schwab S, Teehan B, Eknoyan G. Serum beta-2 microglobulin levels predict mortality in dialysis patients: results of the HEMO study. J Am Soc Nephrol. 2006 Feb; 17(2):546-55.

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Armen RS, Daggett V. Characterization of two distinct beta2-microglobulin unfolding intermediates that may lead to amyloid fibrils of different morphology. Biochemistry. 2005 Dec 13; 44(49):16098-107.

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Armen RS, DeMarco ML, Alonso DO, Daggett V. Pauling and Corey's alpha-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid disease. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11622-7.

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Teehan GS, Guo D, Perianayagam MC, Balakrishnan VS, Pereira BJ, Jaber BL. Reprocessed (high-flux) Polyflux dialyzers resist trans-membrane endotoxin passage and attenuate inflammatory markers. Blood Purif. 2004; 22(4):329-37.

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