"Chymotrypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.
| Descriptor ID |
D002918
|
| MeSH Number(s) |
D08.811.277.656.300.760.176 D08.811.277.656.959.350.176
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Chymotrypsin".
Below are MeSH descriptors whose meaning is more specific than "Chymotrypsin".
This graph shows the total number of publications written about "Chymotrypsin" by people in this website by year, and whether "Chymotrypsin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chymotrypsin" by people in Profiles.
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Mehta DI, He Z, Bornstein J, Molle-Rios Z, Conwell DL, Horvath K. Report on the Short Endoscopic Exocrine Pancreatic Function Test in Children and Young Adults. Pancreas. 2020 May/Jun; 49(5):642-649.
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Alleyne T, Sampson VB. Early electron transfer in cytochrome c oxidase occurs by a chymotrypsin type relay. West Indian Med J. 2009 Dec; 58(6):499-505.
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Valaitis AP, Augustin S, Clancy KM. Purification and characterization of the western spruce budworm larval midgut proteinases and comparison of gut activities of laboratory-reared and field-collected insects. Insect Biochem Mol Biol. 1999 May; 29(5):405-15.
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Reginato AM, Bashey RI, Rosselot G, Leach RM, Gay CV, Jimenez SA. Type X collagen biosynthesis and expression in avian tibial dyschondroplasia. Osteoarthritis Cartilage. 1998 Mar; 6(2):125-36.
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Reginato AM, Jimenez SA. Biochemical characterization of the native tissue form of type X collagen from embryonic chick sternal cartilage and identification of a chymotrypsin-sensitive site within its triple-helical domain. Biochem J. 1991 Jan 15; 273(Pt 2):333-8.
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Sayama S, Iozzo RV, Lazarus GS, Schechter NM. Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans. J Biol Chem. 1987 May 15; 262(14):6808-15.
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Blondin J, Janoff A. The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes. J Clin Invest. 1976 Oct; 58(4):971-9.
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Feinstein G, Malemud CJ, Janoff A. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13; 429(3):925-32.
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Janoff A, Feinstein G, Malemud CJ, Elias JM. Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue. J Clin Invest. 1976 Mar; 57(3):615-24.
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Feinstein G, Janoff A. A rapid method for purification of human granulocyte cationic neutral proteases: purification and characterization of human granulocyte chymotrypsin-like enzyme. Biochim Biophys Acta. 1975 Oct 22; 403(2):477-92.