Clozapine

"Clozapine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Descriptor ID	D003024
MeSH Number(s)	D03.633.300.240.220
Concept/Terms	Clozapine Clozapine Clozaril Clozaril Leponex Leponex

Below are MeSH descriptors whose meaning is more general than "Clozapine".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 3-Ring [D03.633.300]
Dibenzazepines [D03.633.300.240]
Clozapine [D03.633.300.240.220]

Below are MeSH descriptors whose meaning is related to "Clozapine".

Below are MeSH descriptors whose meaning is more specific than "Clozapine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Clozapine" by people in this website by year, and whether "Clozapine" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 1998 and 1999 and 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	1	0	1
1998	1	1	2
1999	2	0	2
2000	0	1	1
2003	1	0	1
2004	1	0	1
2008	2	0	2
2023	1	0	1

Below are the most recent publications written about "Clozapine" by people in Profiles.

Kelly DL, Glassman M, Wonodi I, Vyas G, Richardson CM, Nwulia E, Wehring HJ, Oduguwa T, Mackowick M, Hipolito MMS, Peters O, Rai N, Park J, Adebayo AO, Gorelick DA, Weiner E, Liu F, Kearns AM, Adams HA, Love RC, Chen S, Olaniyan A, Ambulos N, McKoy D, Nallani MC, Lanzkron S, Mengistab M, Barr B, Davis E, Lawal R, Buchanan RW, Adebayo R. Clozapine and neutrophil response in patients of African descent: A six-month, multinational, prospective, open-label clinical trial. Schizophr Res. 2024 06; 268:312-322.

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Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Fern? J, Gebhardt S, Hinney A, Remschmidt H, Krieg JC, Mehler-Wex C, N?then MM, Hebebrand J, Steen VM. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Mol Psychiatry. 2009 Mar; 14(3):308-17.

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Ahmed MR, Gurevich VV, Dalby KN, Benovic JL, Gurevich EV. Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation. J Pharmacol Exp Ther. 2008 Apr; 325(1):276-83.

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Yablonsky-Alter E, Gashi E, Lidsky TI, Wang HY, Banerjee SP. Clozapine protection against gestational cocaine-induced neurochemical abnormalities. J Pharmacol Exp Ther. 2005 Jan; 312(1):297-302.

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Sporn A, Gogtay N, Ortiz-Aguayo R, Alfaro C, Tossell J, Lenane M, Gochman P, Rapoport JL. Clozapine-induced neutropenia in children: management with lithium carbonate. J Child Adolesc Psychopharmacol. 2003; 13(3):401-4.

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Bhatnagar A, Willins DL, Gray JA, Woods J, Benovic JL, Roth BL. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem. 2001 Mar 16; 276(11):8269-77.

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Simpson GM, Josiassen RC, Stanilla JK, de Leon J, Nair C, Abraham G, Odom-White A, Turner RM. Double-blind study of clozapine dose response in chronic schizophrenia. Am J Psychiatry. 1999 Nov; 156(11):1744-50.

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Nair CJ, Josiassen RC, Abraham G, Stanilla JK, Tracy JI, Simpson GM. Does akathisia influence psychopathology in psychotic patients treated with clozapine? Biol Psychiatry. 1999 May 15; 45(10):1376-83.

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Verghese C, Abraham G, Nair C, Stanilla JK, de Leon J, Phillips MI, Simpson GM. Absence of changes in antidiuretic hormone, angiotensin II, and atrial natriuretic peptide with clozapine treatment of polydipsia-hyponatremia: 2 case reports. J Clin Psychiatry. 1998 Aug; 59(8):415-9.

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Schneider JS, Wade T, Lidsky TI. Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT-1 mRNA in the striatum. Neuroreport. 1998 Jan 05; 9(1):133-6.

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