Electron Transport Complex IV

"Electron Transport Complex IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.

Descriptor ID	D003576
MeSH Number(s)	D05.500.562.374 D08.811.600.250.687 D08.811.682.285 D12.776.157.530.450.250.875.304 D12.776.543.277.687 D12.776.543.585.450.250.875.484
Concept/Terms	Electron Transport Complex IV Electron Transport Complex IV Ferrocytochrome c Oxygen Oxidoreductase Cytochrome-c Oxidase (Complex IV) Cytochrome Oxidase Oxidase, Cytochrome Cytochrome-c Oxidase Cytochrome c Oxidase Oxidase, Cytochrome-c Signal Peptide p25-Subunit IV Cytochrome Oxidase Signal Peptide p25-Subunit IV Cytochrome Oxidase Signal Peptide p25 Subunit IV Cytochrome Oxidase Pre-CTOX p25 p25 Presequence Peptide-Cytochrome Oxidase p25 Presequence Peptide Cytochrome Oxidase Cytochrome-c Oxidase Subunit III Cytochrome-c Oxidase Subunit III Cytochrome c Oxidase Subunit III Subunit III, Cytochrome Oxidase Cytochrome Oxidase Subunit III Cytochrome-c Oxidase Subunit IV Cytochrome-c Oxidase Subunit IV Cytochrome c Oxidase Subunit IV Cytochrome aa3 Cytochrome aa3 Heme aa3 Cytochrome Oxidase Cytochrome a,a3 Cytochrome c Oxidase Subunit VIa Cytochrome c Oxidase Subunit VIa

Below are MeSH descriptors whose meaning is more general than "Electron Transport Complex IV".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Multienzyme Complexes [D05.500.562]
Electron Transport Complex IV [D05.500.562.374]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Multienzyme Complexes [D08.811.600]
Electron Transport Chain Complex Proteins [D08.811.600.250]
Electron Transport Complex IV [D08.811.600.250.687]
Oxidoreductases [D08.811.682]
Electron Transport Complex IV [D08.811.682.285]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Cation Transport Proteins [D12.776.157.530.450.250]
Proton Pumps [D12.776.157.530.450.250.875]
Electron Transport Complex IV [D12.776.157.530.450.250.875.304]
Membrane Proteins [D12.776.543]
Electron Transport Chain Complex Proteins [D12.776.543.277]
Electron Transport Complex IV [D12.776.543.277.687]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Cation Transport Proteins [D12.776.543.585.450.250]
Proton Pumps [D12.776.543.585.450.250.875]
Electron Transport Complex IV [D12.776.543.585.450.250.875.484]

Below are MeSH descriptors whose meaning is related to "Electron Transport Complex IV".

Below are MeSH descriptors whose meaning is more specific than "Electron Transport Complex IV".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Electron Transport Complex IV" by people in this website by year, and whether "Electron Transport Complex IV" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 2 publications in 2009 and 2012 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2001	1	0	1
2004	0	1	1
2007	1	0	1
2009	2	0	2
2011	0	1	1
2012	1	1	2
2017	2	0	2

Below are the most recent publications written about "Electron Transport Complex IV" by people in Profiles.

Hasbrook M, Yonekawa Y, Van Laere L, Shah AR, Capone A. Bilateral persistent fetal vasculature and a chromosome 10 mutation including COX15. Can J Ophthalmol. 2017 12; 52(6):e203-e205.

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Alleyne T, Ignacio DN, Sampson VB, Ashe D, Wilson M. Simulating the slow to fast switch in cytochrome c oxidase catalysis by introducing a loop flip near the enzyme's cytochrome c (substrate) binding site. Biotechnol Appl Biochem. 2017 Sep; 64(5):677-685.

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Ashe D, Alleyne T, Sampson V. Substrate binding-dissociation and intermolecular electron transfer in cytochrome c oxidase are driven by energy-dependent conformational changes in the enzyme and substrate. Biotechnol Appl Biochem. 2012 May-Jun; 59(3):213-22.

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Sotgia F, Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Philp NJ, Pestell RG, Lisanti MP. Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue. Cell Cycle. 2012 Apr 01; 11(7):1445-54.

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Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Pavlides S, Tsirigos A, Ertel A, Pestell RG, Broda P, Minetti C, Lisanti MP, Sotgia F. Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle. 2011 Dec 01; 10(23):4047-64.

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Alleyne T, Sampson VB. Early electron transfer in cytochrome c oxidase occurs by a chymotrypsin type relay. West Indian Med J. 2009 Dec; 58(6):499-505.

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Sampson VB, Alleyne T, Ashe D. Probing the specifics of substrate binding for cytochrome c oxidase: a computer assisted approach. West Indian Med J. 2009 Jan; 58(1):54-60.

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Amores E, Forde-Baker J, Ginsburg BY, Nelson LS. Cytochrome-C oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2007 Jun-Aug; 45(5):461; author reply 462.

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Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. J Neurosci. 2004 Jun 30; 24(26):5909-12.

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Sampson V, Alleyne T. Cytochrome c/cytochrome c oxidase interaction. Direct structural evidence for conformational changes during enzyme turnover. Eur J Biochem. 2001 Dec; 268(24):6534-44.

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