A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

Descriptor ID	D003577
MeSH Number(s)	D08.244.453 D08.811.682.690.708.170 D12.776.422.220.453
Concept/Terms	Cytochrome P-450 Enzyme System Cytochrome P-450 Enzyme System Cytochrome P 450 Enzyme System Cytochrome P450 P-450 Enzymes Enzymes, P-450 P 450 Enzymes P450 Enzymes Enzymes, P450 CYP450 Family Cytochrome P450 Superfamily Superfamily, Cytochrome P450 Cytochrome P-450 Superfamily Cytochrome P 450 Superfamily Superfamily, Cytochrome P-450 Cytochrome p450 Families Cytochrome P-450 Families Cytochrome P 450 Families CYP450 Superfamily Superfamily, CYP450 Cytochrome P-450 Cytochrome P 450 Cytochrome P-450 Enzymes Cytochrome P 450 Enzymes Enzymes, Cytochrome P-450 P-450 Enzymes, Cytochrome Cytochrome P-450 Monooxygenase Cytochrome P-450 Monooxygenase Cytochrome P 450 Monooxygenase Monooxygenase, Cytochrome P-450 Cytochrome P-450-Dependent Monooxygenase Cytochrome P 450 Dependent Monooxygenase Monooxygenase, Cytochrome P-450-Dependent Cytochrome P-450 Oxygenase Cytochrome P-450 Oxygenase Cytochrome P 450 Oxygenase

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 Enzyme System".

Below are MeSH descriptors whose meaning is related to "Cytochrome P-450 Enzyme System".

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 Enzyme System".