Diazepam

"Diazepam" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.

Descriptor ID	D003975
MeSH Number(s)	D03.633.100.079.080.070.216
Concept/Terms	Diazepam Diazepam 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diazemuls Diazemuls Faustan Faustan Valium Valium Seduxen Seduxen Sibazon Sibazon Stesolid Stesolid Apaurin Apaurin Relanium Relanium

Below are MeSH descriptors whose meaning is more general than "Diazepam".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Benzazepines [D03.633.100.079]
Benzodiazepines [D03.633.100.079.080]
Benzodiazepinones [D03.633.100.079.080.070]
Diazepam [D03.633.100.079.080.070.216]

Below are MeSH descriptors whose meaning is related to "Diazepam".

Below are MeSH descriptors whose meaning is more specific than "Diazepam".

Diazepam
Nordazepam

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Diazepam" by people in this website by year, and whether "Diazepam" was a major or minor topic of these publications.

Bar chart showing 26 publications over 14 distinct years, with a maximum of 5 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	2	3
2000	1	0	1
2001	0	1	1
2006	0	1	1
2008	0	1	1
2009	0	1	1
2010	1	0	1
2014	2	0	2
2016	1	1	2
2018	0	1	1
2020	1	1	2
2021	2	3	5
2022	2	2	4
2023	0	1	1

Below are the most recent publications written about "Diazepam" by people in Profiles.

Changoor S, Giakas A, Sacks K, Asma A, Lang RS, Yorgova P, Rogers K, Gabos PG, Shah SA. The Role of Liposomal Bupivacaine in Multimodal Pain Management Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: Faster and Farther With Less Opioids. Spine (Phila Pa 1976). 2024 Jan 15; 49(2):E11-E16.

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Asadi-Pooya AA, Hosseini SA. Seizure rescue medications are missing from in-flight medical emergency kits. Epilepsy Behav. 2022 12; 137(Pt A):108976.

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Misra SN, Sperling MR, Rao VR, Peters JM, Davis C, Carrazana E, Rabinowicz AL. Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters. Epilepsia. 2022 10; 63(10):2684-2693.

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Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Desai J, Vazquez B, Samara E, Misra SN, Carrazana E, Rabinowicz AL. Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4?h for acute treatment of seizure clusters: A population analysis. Epilepsia. 2022 07; 63(7):1714-1723.

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Sperling MR, Wheless JW, Hogan RE, Dlugos D, Cascino GD, Liow K, Rabinowicz AL, Carrazana E. Use of second doses of Valtoco? (diazepam nasal spray) across 24?hours after the initial dose for out-of-hospital seizure clusters: Results from a phase 3, open-label, repeat-dose safety study. Epilepsia. 2022 04; 63(4):836-843.

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Wheless JW, Miller I, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E. Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. Epilepsia. 2021 10; 62(10):2485-2495.

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Higdon LM, Sperling MR. A review of a diazepam nasal spray for the treatment of acute seizure clusters and prolonged seizures. Expert Rev Neurother. 2021 11; 21(11):1207-1212.

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Miller I, Wheless JW, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E. Consistent safety and tolerability of Valtoco? (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long-term, open-label, repeat-dose safety study. Epilepsia Open. 2021 09; 6(3):504-512.

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Segal EB, Tarquinio D, Miller I, Wheless JW, Dlugos D, Biton V, Cascino GD, Desai J, Hogan RE, Liow K, Sperling MR, Vazquez B, Cook DF, Rabinowicz AL, Carrazana E. Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. Epilepsia. 2021 06; 62(6):1442-1450.

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Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Liow K, Desai J, Davis C, Rabinowicz AL, Carrazana E. Lack of observed tolerance to diazepam nasal spray (Valtoco?) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. Epilepsy Behav. 2021 07; 120:107983.

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