"Epilepsy, Tonic-Clonic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Descriptor ID |
D004830
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| MeSH Number(s) |
C10.228.140.490.375.290
|
| Concept/Terms |
Epilepsy, Tonic-Clonic- Epilepsy, Tonic-Clonic
- Epilepsies, Tonic-Clonic
- Epilepsy, Tonic Clonic
- Tonic-Clonic Epilepsies
- Tonic-Clonic Epilepsy
- Epilepsy, Grand Mal
- Grand Mal Epilepsy
- Epilepsy, Major
- Major Epilepsies
- Major Epilepsy
- Grand Mal Seizure Disorder
- Major Motor Seizure Disorder
- Tonic-Clonic Seizure Syndrome
- Seizure Syndrome, Tonic-Clonic
- Seizure Syndromes, Tonic-Clonic
- Syndrome, Tonic-Clonic Seizure
- Syndromes, Tonic-Clonic Seizure
- Tonic Clonic Seizure Syndrome
- Tonic-Clonic Seizure Syndromes
- Seizure Disorder, Major Motor
- Seizure Disorder, Tonic Clonic
- Tonic Clonic Convulsions
- Convulsion, Tonic Clonic
- Convulsions, Tonic Clonic
- Tonic Clonic Convulsion
- Tonic-Clonic Convulsion Disorder
- Convulsion Disorder, Tonic-Clonic
- Convulsion Disorders, Tonic-Clonic
- Disorder, Tonic-Clonic Convulsion
- Disorders, Tonic-Clonic Convulsion
- Tonic Clonic Convulsion Disorder
- Tonic-Clonic Convulsion Disorders
- Tonic-Clonic Convulsion Syndrome
- Convulsion Syndrome, Tonic-Clonic
- Convulsion Syndromes, Tonic-Clonic
- Syndrome, Tonic-Clonic Convulsion
- Syndromes, Tonic-Clonic Convulsion
- Tonic Clonic Convulsion Syndrome
- Tonic-Clonic Convulsion Syndromes
- Tonic-Clonic Seizure Disorder
- Disorder, Tonic-Clonic Seizure
- Disorders, Tonic-Clonic Seizure
- Seizure Disorder, Tonic-Clonic
- Seizure Disorders, Tonic-Clonic
- Tonic Clonic Seizure Disorder
- Tonic-Clonic Seizure Disorders
- Convulsions, Grand Mal
- Convulsion, Grand Mal
- Grand Mal Convulsion
- Grand Mal Convulsions
- Seizure Disorder, Grand Mal
Epilepsy, Tonic-Clonic, Symptomatic- Epilepsy, Tonic-Clonic, Symptomatic
- Symptomatic Tonic-Clonic Epilepsy
- Epilepsies, Symptomatic Tonic-Clonic
- Epilepsy, Symptomatic Tonic-Clonic
- Symptomatic Tonic Clonic Epilepsy
- Symptomatic Tonic-Clonic Epilepsies
- Tonic-Clonic Epilepsies, Symptomatic
- Tonic-Clonic Epilepsy, Symptomatic
Cryptogenic Tonic-Clonic Epilepsy- Cryptogenic Tonic-Clonic Epilepsy
- Cryptogenic Tonic Clonic Epilepsy
- Cryptogenic Tonic-Clonic Epilepsies
- Epilepsies, Cryptogenic Tonic-Clonic
- Epilepsy, Cryptogenic Tonic-Clonic
- Tonic-Clonic Epilepsies, Cryptogenic
- Tonic-Clonic Epilepsy, Cryptogenic
- Epilepsy, Tonic-Clonic, Cryptogenic
Epilepsy, Tonic-Clonic, Familial- Epilepsy, Tonic-Clonic, Familial
- Familial Tonic-Clonic Epilepsy
- Epilepsies, Familial Tonic-Clonic
- Epilepsy, Familial Tonic-Clonic
- Familial Tonic Clonic Epilepsy
- Familial Tonic-Clonic Epilepsies
- Tonic-Clonic Epilepsies, Familial
- Tonic-Clonic Epilepsy, Familial
|
Below are MeSH descriptors whose meaning is more general than "Epilepsy, Tonic-Clonic".
Below are MeSH descriptors whose meaning is more specific than "Epilepsy, Tonic-Clonic".
This graph shows the total number of publications written about "Epilepsy, Tonic-Clonic" by people in this website by year, and whether "Epilepsy, Tonic-Clonic" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 4 | 4 |
| 2007 | 1 | 2 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 3 | 3 |
| 2012 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Epilepsy, Tonic-Clonic" by people in Profiles.
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Tarighati Rasekhi R, Devlin KN, Mass JA, Donmez M, Asma B, Sperling MR, Nei M. Improving prediction of sudden unexpected death in epilepsy: From SUDEP-7 to SUDEP-3. Epilepsia. 2021 07; 62(7):1536-1545.
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Asadi-Pooya AA, Tomson T. A reappraisal of injuries and accidents in people with epilepsy. Curr Opin Neurol. 2021 04 01; 34(2):182-187.
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Halford JJ, Sperling MR, Nair DR, Dlugos DJ, Tatum WO, Harvey J, French JA, Pollard JR, Faught E, Noe KH, Henry TR, Jetter GM, Lie OV, Morgan LC, Girouard MR, Cardenas DP, Whitmire LE, Cavazos JE. Detection of generalized tonic-clonic seizures using surface electromyographic monitoring. Epilepsia. 2017 11; 58(11):1861-1869.
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Ramgopal S, Vendrame M, Shah A, Gregas M, Zarowski M, Rotenberg A, Alexopoulos AV, Wyllie E, Kothare SV, Loddenkemper T. Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients. Seizure. 2012 Sep; 21(7):535-9.
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Loddenkemper T, Vendrame M, Zarowski M, Gregas M, Alexopoulos AV, Wyllie E, Kothare SV. Circadian patterns of pediatric seizures. Neurology. 2011 Jan 11; 76(2):145-53.
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Nei M, Zangaladze AT, Sharan A, Ho RT. Interictal epileptiform discharges and asystole. Epilepsy Res. 2011 Feb; 93(2-3):204-7.
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Asadi-Pooya AA, Petramfar P, Taghipour M. Refractory hiccups due to phenytoin therapy. Neurol India. 2011 Jan-Feb; 59(1):68.
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D'Orazio JL, Curtis JA. Overdose of propafenone surreptitiously sold as "Percocet". J Emerg Med. 2011 Aug; 41(2):172-5.
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Petramfar P, Yaghoobi E, Nemati R, Asadi-Pooya AA. Serum creatine phosphokinase is helpful in distinguishing generalized tonic-clonic seizures from psychogenic nonepileptic seizures and vasovagal syncope. Epilepsy Behav. 2009 Jul; 15(3):330-2.
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Chandrasekar T, Sharan AD, Sperling MR. Postoperative auras and the risk of recurrent seizures. Epilepsy Res. 2008 Feb; 78(2-3):195-200.