Extracellular Matrix

"Extracellular Matrix" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Descriptor ID	D005109
MeSH Number(s)	A11.284.295.310
Concept/Terms	Extracellular Matrix Extracellular Matrix Matrix, Extracellular Extracellular Matrices Matrices, Extracellular

Below are MeSH descriptors whose meaning is more general than "Extracellular Matrix".

Anatomy [A]
Cells [A11]
Cellular Structures [A11.284]
Extracellular Space [A11.284.295]
Extracellular Matrix [A11.284.295.310]

Below are MeSH descriptors whose meaning is related to "Extracellular Matrix".

Below are MeSH descriptors whose meaning is more specific than "Extracellular Matrix".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Extracellular Matrix" by people in this website by year, and whether "Extracellular Matrix" was a major or minor topic of these publications.

Bar chart showing 301 publications over 29 distinct years, with a maximum of 22 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	0	2
1997	3	2	5
1998	1	1	2
1999	1	4	5
2000	2	3	5
2001	2	4	6
2002	4	10	14
2003	3	14	17
2004	6	6	12
2005	2	10	12
2006	1	8	9
2007	6	4	10
2008	1	7	8
2009	7	7	14
2010	2	6	8
2011	7	9	16
2012	9	7	16
2013	8	7	15
2014	10	12	22
2015	6	8	14
2016	7	9	16
2017	3	7	10
2018	6	8	14
2019	7	3	10
2020	5	7	12
2021	2	5	7
2022	4	2	6
2023	1	7	8
2024	3	3	6

Below are the most recent publications written about "Extracellular Matrix" by people in Profiles.

Gao H, Pol M, Makara CA, Song J, Zhang H, Zou X, Benson JM, Burris DL, Fox JM, Jia X. Bio-orthogonal tuning of matrix properties during 3D cell culture to induce morphological and phenotypic changes. Nat Protoc. 2025 03; 20(3):727-778.

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Arriagada C, Lin E, Schonning M, Astrof S. Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development. Dev Cell. 2025 01 06; 60(1):62-84.e7.

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Hoeft K, Koch L, Ziegler S, Zhang L, Luetke S, Tanzer MC, Mohanta D, Schumacher D, Schreibing F, Long Q, Kim H, Klinkhammer BM, Schikarski C, Maryam S, Baens M, Hermann J, Krieg S, Peisker F, De Laporte L, Schaefer GJ, Menzel S, Jankowski J, Humphreys BD, Wahida A, Schneider RK, Versele M, Boor P, Mann M, Sengle G, Hayat S, Kramann R. ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts. J Clin Invest. 2024 Sep 17; 134(18).

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Dogan E, Galifi CA, Cecen B, Shukla R, Wood TL, Miri AK. Extracellular matrix regulation of cell spheroid invasion in a 3D bioprinted solid tumor-on-a-chip. Acta Biomater. 2024 09 15; 186:156-166.

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Sao K, Risbud MV. Sdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine. Matrix Biol. 2024 Aug; 131:46-61.

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Huang H, Hwang J, Anilkumar S, Kiick KL. Controlled Release of Drugs from Extracellular Matrix-Derived Peptide-Based Nanovesicles through Tailored Noncovalent Interactions. Biomacromolecules. 2024 04 08; 25(4):2408-2422.

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Moriarty TF, Hickok NJ, Saeed K, Schaer TP, Chen AF, Schwarz EM. The 2023 Orthopaedic Research Society International Consensus Meeting on musculoskeletal infection. J Orthop Res. 2024 03; 42(3):497-499.

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Pol M, Gao H, Zhang H, George OJ, Fox JM, Jia X. Dynamic modulation of matrix adhesiveness induces epithelial-to-mesenchymal transition in prostate cancer cells in 3D. Biomaterials. 2023 08; 299:122180.

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Melamed S, Zaffryar-Eilot S, Nadjar-Boger E, Aviram R, Zhao H, Yaseen-Badarne W, Kalev-Altman R, Sela-Donenfeld D, Lewinson O, Astrof S, Hasson P, Wolfenson H. Initiation of fibronectin fibrillogenesis is an enzyme-dependent process. Cell Rep. 2023 05 30; 42(5):112473.

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Fertala J, Wang ML, Rivlin M, Beredjiklian PK, Abboud J, Arnold WV, Fertala A. Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury. Biomolecules. 2023 04 27; 13(5).

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