"Glutamate Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
| Descriptor ID |
D005968
|
| MeSH Number(s) |
D08.811.520.224.125.250
|
| Concept/Terms |
Glutamate Decarboxylase- Glutamate Decarboxylase
- Decarboxylase, Glutamate
- Glutamic Acid Decarboxylase
- Acid Decarboxylase, Glutamic
- Decarboxylase, Glutamic Acid
- Glutamate Carboxy-Lyase
- Carboxy-Lyase, Glutamate
- Glutamate Carboxy Lyase
|
Below are MeSH descriptors whose meaning is more general than "Glutamate Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate Decarboxylase".
This graph shows the total number of publications written about "Glutamate Decarboxylase" by people in this website by year, and whether "Glutamate Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 3 | 1 | 4 |
| 2006 | 1 | 1 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 1 | 2 |
| 2010 | 3 | 0 | 3 |
| 2012 | 0 | 2 | 2 |
| 2013 | 3 | 0 | 3 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
| 2024 | 2 | 0 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glutamate Decarboxylase" by people in Profiles.
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Tsiortou P, Alexopoulos H, Kyriakidis K, Kosmidis M, Barba C, Akrivou S, Michalopoulos I, Politis P, Dalakas MC. Immunogenetic Studies in Patients With GAD-Positive Stiff-Person Syndrome Reveal Novel Lymphocytic Genes and KLK10-Gene Variants. Neurol Neuroimmunol Neuroinflamm. 2025 Mar; 12(2):e200373.
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Dalakas MC. Stiff-person syndrome and related disorders - diagnosis, mechanisms and therapies. Nat Rev Neurol. 2024 10; 20(10):587-601.
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Dalakas MC. Stiff Person Syndrome and GAD Antibody-Spectrum Disorders. Continuum (Minneap Minn). 2024 Aug 01; 30(4):1110-1135.
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Yi J, Dalakas MC. Long-term Effectiveness of IVIg Maintenance Therapy in 36 Patients With GAD Antibody-Positive Stiff-Person Syndrome. Neurol Neuroimmunol Neuroinflamm. 2022 09; 9(5).
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Dalakas MC. Stiff-person Syndrome and GAD Antibody-spectrum Disorders: GABAergic Neuronal Excitability, Immunopathogenesis and Update on Antibody Therapies. Neurotherapeutics. 2022 04; 19(3):832-847.
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Dalakas MC, Rakocevic G, Dambrosia JM, Alexopoulos H, McElroy B. A double-blind, placebo-controlled study of rituximab in patients with stiff person syndrome. Ann Neurol. 2017 Aug; 82(2):271-277.
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Fouka P, Alexopoulos H, Akrivou S, Trohatou O, Politis PK, Dalakas MC. GAD65 epitope mapping and search for novel autoantibodies in GAD-associated neurological disorders. J Neuroimmunol. 2015 Apr 15; 281:73-7.
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Volk DW, Chitrapu A, Edelson JR, Lewis DA. Chemokine receptors and cortical interneuron dysfunction in schizophrenia. Schizophr Res. 2015 Sep; 167(1-3):12-7.
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Tatard-Leitman VM, Jutzeler CR, Suh J, Saunders JA, Billingslea EN, Morita S, White R, Featherstone RE, Ray R, Ortinski PI, Banerjee A, Gandal MJ, Lin R, Alexandrescu A, Liang Y, Gur RE, Borgmann-Winter KE, Carlson GC, Hahn CG, Siegel SJ. Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry. 2015 Mar 15; 77(6):556-68.
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Markakis I, Alexopoulos H, Poulopoulou C, Akrivou S, Papathanasiou A, Katsiva V, Lyrakos G, Gekas G, Dalakas MC. Immunotherapy-responsive limbic encephalitis with antibodies to glutamic acid decarboxylase. J Neurol Sci. 2014 Aug 15; 343(1-2):192-4.