"Granulosa Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).
| Descriptor ID |
D006107
|
| MeSH Number(s) |
A05.360.319.114.630.535.200 A06.407.312.497.535.300 A11.382.812 A11.436.329
|
| Concept/Terms |
Granulosa Cells- Granulosa Cells
- Cell, Granulosa
- Cells, Granulosa
- Granulosa Cell
|
Below are MeSH descriptors whose meaning is more general than "Granulosa Cells".
Below are MeSH descriptors whose meaning is more specific than "Granulosa Cells".
This graph shows the total number of publications written about "Granulosa Cells" by people in this website by year, and whether "Granulosa Cells" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Granulosa Cells" by people in Profiles.
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Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Hum Reprod. 2022 05 30; 37(6):1274-1286.
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Yu B, Russanova VR, Gravina S, Hartley S, Mullikin JC, Ignezweski A, Graham J, Segars JH, DeCherney AH, Howard BH. DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3'-end GC density. Oncotarget. 2015 Feb 28; 6(6):3627-43.
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Edson MA, Nalam RL, Clementi C, Franco HL, Demayo FJ, Lyons KM, Pangas SA, Matzuk MM. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol. 2010 Jun; 24(6):1251-66.
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Wang L, Nair AK, Menon KM. Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: relationship to sterol metabolism. Mol Endocrinol. 2007 Sep; 21(9):2233-41.
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Nair AK, Peegel H, Menon KM. The role of luteinizing hormone/human chorionic gonadotropin receptor-specific mRNA binding protein in regulating receptor expression in human ovarian granulosa cells. J Clin Endocrinol Metab. 2006 Jun; 91(6):2239-43.
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Makrigiannakis A, Coukos G, Christofidou-Solomidou M, Gour BJ, Radice GL, Blaschuk O, Coutifaris C. N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: a role in follicular atresia and luteolysis? Am J Pathol. 1999 May; 154(5):1391-406.