Cardiomegaly

"Cardiomegaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Descriptor ID	D006332
MeSH Number(s)	C14.280.195 C23.300.775.250
Concept/Terms	Cardiomegaly Cardiomegaly Heart Enlargement Enlargement, Heart Enlarged Heart Heart, Enlarged Cardiac Hypertrophy Cardiac Hypertrophy Heart Hypertrophy

Below are MeSH descriptors whose meaning is more general than "Cardiomegaly".

Diseases [C]
Cardiovascular Diseases [C14]
Heart Diseases [C14.280]
Cardiomegaly [C14.280.195]
Pathological Conditions, Signs and Symptoms [C23]
Pathological Conditions, Anatomical [C23.300]
Hypertrophy [C23.300.775]
Cardiomegaly [C23.300.775.250]

Below are MeSH descriptors whose meaning is more specific than "Cardiomegaly".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cardiomegaly" by people in this website by year, and whether "Cardiomegaly" was a major or minor topic of these publications.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 2 publications in 2006 and 2008 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2006	0	2	2
2008	2	0	2
2009	1	0	1
2010	0	2	2
2012	0	1	1

Below are the most recent publications written about "Cardiomegaly" by people in Profiles.

Seqqat R, Guo X, Rafiq K, Kolpakov MA, Guo J, Koch WJ, Houser SR, Dell'italia LJ, Sabri A. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. J Mol Cell Cardiol. 2012 Aug; 53(2):240-9.

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Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7.

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Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010 Jul; 120(7):2280-91.

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Kolwicz SC, MacDonnell SM, Renna BF, Reger PO, Seqqat R, Rafiq K, Kendrick ZV, Houser SR, Sabri A, Libonati JR. Left ventricular remodeling with exercise in hypertension. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1361-8.

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Augustus AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle. 2008 Aug 15; 7(16):2509-18.

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Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H657-66.

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Funakoshi H, Chan TO, Good JC, Libonati JR, Piuhola J, Chen X, MacDonnell SM, Lee LL, Herrmann DE, Zhang J, Martini J, Palmer TM, Sanbe A, Robbins J, Houser SR, Koch WJ, Feldman AM. Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation. 2006 Nov 21; 114(21):2240-50.

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Mills GD, Harris DM, Chen X, Houser SR. Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1129-38.

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Fasseas P, Lee-Dorn R, Sokil AB, VanDecker W. Giant left atrium. Tex Heart Inst J. 2001; 28(2):158-9.

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Jaweed MM, Herbison GJ, Ditunno JF, Gordon EE. Heart weight of rat in different exercises. Arch Phys Med Rehabil. 1974 Dec; 55(12):539-44.

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