Heme Oxygenase (Decyclizing)
"Heme Oxygenase (Decyclizing)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt.
Descriptor ID |
D006419
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MeSH Number(s) |
D08.811.682.690.708.410
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Heme Oxygenase (Decyclizing)".
Below are MeSH descriptors whose meaning is more specific than "Heme Oxygenase (Decyclizing)".
This graph shows the total number of publications written about "Heme Oxygenase (Decyclizing)" by people in this website by year, and whether "Heme Oxygenase (Decyclizing)" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 1 | 2 | 3 |
2004 | 3 | 1 | 4 |
2005 | 3 | 3 | 6 |
2006 | 3 | 1 | 4 |
2007 | 3 | 0 | 3 |
2008 | 0 | 3 | 3 |
2009 | 2 | 0 | 2 |
2010 | 0 | 1 | 1 |
2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Heme Oxygenase (Decyclizing)" by people in Profiles.
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Rodriguez F, Lopez B, Perez C, Fenoy FJ, Hernandez I, Stec DE, Li Volti G, Salom MG. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats. Am J Physiol Regul Integr Comp Physiol. 2011 Nov; 301(5):R1540-8.
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Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, Solomides CC, Javvadi P, Koumenis C, Cengel KA, Christofidou-Solomidou M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res. 2010 May; 173(5):590-601.
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Bellner L, Martinelli L, Halilovic A, Patil K, Puri N, Dunn MW, Regan RF, Schwartzman ML. Heme oxygenase-2 deletion causes endothelial cell activation marked by oxidative stress, inflammation, and angiogenesis. J Pharmacol Exp Ther. 2009 Dec; 331(3):925-32.
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Chen-Roetling J, Li Z, Chen M, Awe OO, Regan RF. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology. 2009 Apr; 56(5):922-8.
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Chen-Roetling J, Li Z, Regan RF. Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity. Curr Neurovasc Res. 2008 Aug; 5(3):193-8.
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Bellner L, Vitto M, Patil KA, Dunn MW, Regan R, Laniado-Schwartzman M. Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin. Exp Eye Res. 2008 Sep; 87(3):268-78.
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Crowley RW, Medel R, Kassell NF, Dumont AS. New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage. Drug Discov Today. 2008 Mar; 13(5-6):254-60.
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Salom MG, Cerón SN, Rodriguez F, Lopez B, Hernández I, Martínez JG, Losa AM, Fenoy FJ. Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3542-9.
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Chen M, Regan RF. Time course of increased heme oxygenase activity and expression after experimental intracerebral hemorrhage: correlation with oxidative injury. J Neurochem. 2007 Dec; 103(5):2015-21.
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Qu Y, Chen-Roetling J, Benvenisti-Zarom L, Regan RF. Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice. J Neurosurg. 2007 Mar; 106(3):428-35.