"Hirudins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
| Descriptor ID |
D006629
|
| MeSH Number(s) |
D12.644.861.060.875 D12.776.872.060.875
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hirudins".
Below are MeSH descriptors whose meaning is more specific than "Hirudins".
This graph shows the total number of publications written about "Hirudins" by people in this website by year, and whether "Hirudins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hirudins" by people in Profiles.
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Weeks P, Sieg A, Rajapreyar I, Nathan S, Jumean M, Patel M, Radovancevic R, Kar B, Gregoric I. Bivalirudin for left ventricular assist device thrombosis. J Thromb Thrombolysis. 2018 Nov; 46(4):496-501.
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Orkic Z, Mraovic B, Kvolik S, Istvanic T, Divkovic D, Kristek J. Does the type of anesthesia administered affect the efficacy of medicinal leech therapy after finger replantation: clinical observations in a 6-year-old boy. Paediatr Anaesth. 2012 Jun; 22(6):605-7.
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Schuettrumpf J, Zou J, Zhang Y, Schlachterman A, Liu YL, Edmonson S, Xiao W, Arruda VR. The inhibitory effects of anticoagulation on in vivo gene transfer by adeno-associated viral or adenoviral vectors. Mol Ther. 2006 Jan; 13(1):88-97.