Hydroxylation

"Hydroxylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)

Descriptor ID	D006900
MeSH Number(s)	G02.111.385 G02.607.348 G03.425
Concept/Terms	Hydroxylation Hydroxylation Hydroxylations

Below are MeSH descriptors whose meaning is more general than "Hydroxylation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Hydroxylation [G02.111.385]
Organic Chemistry Phenomena [G02.607]
Hydroxylation [G02.607.348]
Metabolism [G03]
Hydroxylation [G03.425]

Below are MeSH descriptors whose meaning is related to "Hydroxylation".

Below are MeSH descriptors whose meaning is more specific than "Hydroxylation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hydroxylation" by people in this website by year, and whether "Hydroxylation" was a major or minor topic of these publications.

Bar chart showing 19 publications over 16 distinct years, with a maximum of 2 publications in 2000 and 2004 and 2020

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1996	1	1
1999	1	1
2000	2	2
2001	1	1
2002	1	1
2004	2	2
2005	1	1
2012	1	1
2014	1	1
2015	1	1
2016	1	1
2017	1	1
2018	1	1
2019	1	1
2020	2	2
2024	1	1

Below are the most recent publications written about "Hydroxylation" by people in Profiles.

Bergh MS, Bogen IL, Grafinger KE, Huestis MA, ?iestad ?ML. Metabolite markers for three synthetic tryptamines N-ethyl-N-propyltryptamine, 4-hydroxy-N-ethyl-N-propyltryptamine, and 5-methoxy-N-ethyl-N-propyltryptamine. Drug Test Anal. 2024 Dec; 16(12):1544-1557.

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Carlier J, Diao X, Giorgetti R, Busard? FP, Huestis MA. Pyrrolidinyl Synthetic Cathinones a-PHP and 4F-a-PVP Metabolite Profiling Using Human Hepatocyte Incubations. Int J Mol Sci. 2020 Dec 28; 22(1).

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Presley BC, Logan BK, Jansen-Varnum SA. In Vitro Metabolic Profile Elucidation of Synthetic Cannabinoid APP-CHMINACA (PX-3). J Anal Toxicol. 2020 Apr 30; 44(3):226-236.

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Presley BC, Logan BK, Jansen-Varnum SA. In vitro Phase I metabolism of indazole carboxamide synthetic cannabinoid MDMB-CHMINACA via human liver microsome incubation and high-resolution mass spectrometry. Drug Test Anal. 2019 Aug; 11(8):1264-1276.

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Carlier J, Diao X, Huestis MA. Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high resolution mass spectrometry detection. J Pharm Biomed Anal. 2018 Aug 05; 157:27-35.

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Diao X, Carlier J, Zhu M, Huestis MA. Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18. Clin Chem. 2017 Nov; 63(11):1753-1763.

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Moaddel R, Sanghvi M, Ramamoorthy A, Jozwiak K, Singh N, Green C, O'Loughlin K, Torjman M, Wainer IW. Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats. J Pharm Biomed Anal. 2016 Aug 05; 127:3-8.

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Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y. Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3816-25.

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Gandhi AS, Wohlfarth A, Zhu M, Pang S, Castaneto M, Scheidweiler KB, Huestis MA. High-resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135), using cryopreserved human hepatocytes and assessment of metabolic stability with human liver microsomes. Drug Test Anal. 2015 Mar; 7(3):187-98.

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Desta Z, Moaddel R, Ogburn ET, Xu C, Ramamoorthy A, Venkata SL, Sanghvi M, Goldberg ME, Torjman MC, Wainer IW. Stereoselective and regiospecific hydroxylation of ketamine and norketamine. Xenobiotica. 2012 Nov; 42(11):1076-87.

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