Aprotinin

"Aprotinin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

Descriptor ID	D007611
MeSH Number(s)	D12.776.083
Concept/Terms	Aprotinin Aprotinin Trypsin Inhibitor, Basic, Pancreatic Bovine Kunitz Pancreatic Trypsin Inhibitor BPTI, Basic Pancreatic Trypsin Inhibitor Kallikrein-Trypsin Inactivator Inactivator, Kallikrein-Trypsin Kallikrein Trypsin Inactivator Kunitz Pancreatic Trypsin Inhibitor Trypsin Inhibitor, Kunitz, Pancreatic Basic Pancreatic Trypsin Inhibitor Bovine Pancreatic Trypsin Inhibitor Pulmin Pulmin Traskolan Traskolan Dilmintal Dilmintal Zymofren Zymofren Antilysin Antilysin Contrykal Contrykal Kontrykal Kontrikal Contrical Iniprol Iniprol Trasylol Trasylol

Below are MeSH descriptors whose meaning is more general than "Aprotinin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Aprotinin [D12.776.083]

Below are MeSH descriptors whose meaning is related to "Aprotinin".

Below are MeSH descriptors whose meaning is more specific than "Aprotinin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Aprotinin" by people in this website by year, and whether "Aprotinin" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 1996 and 1999 and 2004 and 2006 and 2007 and 2012 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1999	1	0	1
2004	0	1	1
2006	0	1	1
2007	1	0	1
2012	0	1	1
2017	0	1	1

Below are the most recent publications written about "Aprotinin" by people in Profiles.

Gandhi JK, Manzar Z, Bachman LA, Andrews-Pfannkoch C, Knudsen T, Hill M, Schmidt H, Iezzi R, Pulido JS, Marmorstein AD. Fibrin hydrogels as a xenofree and rapidly degradable support for transplantation of retinal pigment epithelium monolayers. Acta Biomater. 2018 02; 67:134-146.

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Newton PO, Bastrom TP, Emans JB, Shah SA, Shufflebarger HL, Sponseller PD, Sucato DJ, Lenke LG. Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures. Spine (Phila Pa 1976). 2012 Nov 01; 37(23):E1459-63.

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Colwell CW, Chelly JE, Murkin JM, Stevens D, O'Keefe TJ, Hall R, Parvizi J. Randomized study of aprotinin effect on transfusions and blood loss in primary THA. Clin Orthop Relat Res. 2007 Dec; 465:189-95.

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Mayer SA, Rincon F. Ultra-early hemostatic therapy for acute intracerebral hemorrhage. Semin Hematol. 2006 Jan; 43(1 Suppl 1):S70-6.

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Rogers DM, Hirst JD. First-principles calculations of protein circular dichroism in the near ultraviolet. Biochemistry. 2004 Aug 31; 43(34):11092-102.

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De Cristofaro R, Landolfi R. Allosteric modulation of BPTI interaction with human alpha- and zeta-thrombin. Eur J Biochem. 1999 Feb; 260(1):97-102.

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Prendergast TW, Furukawa S, Beyer AJ, Eisen HJ, McClurken JB, Jeevanandam V. Defining the role of aprotinin in heart transplantation. Ann Thorac Surg. 1996 Sep; 62(3):670-4.

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Chu ML, Zhang RZ, Pan TC, Stokes D, Conway D, Kuo HJ, Glanville R, Mayer U, Mann K, Deutzmann R, et al. Mosaic structure of globular domains in the human type VI collagen alpha 3 chain: similarity to von Willebrand factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors. EMBO J. 1990 Feb; 9(2):385-93.

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Feldman MD, Sataloff RT, Ballas SK. Autologous fibrin tissue adhesive for cerebrospinal fluid leaks: a controlled study of neurotoxicity. Am J Otol. 1988 Jul; 9(4):302-5.

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Feldman MD, Sataloff RT, Choi HY, Ballas SK. Compatibility of autologous fibrin adhesive with implant materials. Arch Otolaryngol Head Neck Surg. 1988 Feb; 114(2):182-5.

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