"Leupeptins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.
| Descriptor ID |
D007976
|
| MeSH Number(s) |
D12.644.456.580
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leupeptins".
Below are MeSH descriptors whose meaning is more specific than "Leupeptins".
This graph shows the total number of publications written about "Leupeptins" by people in this website by year, and whether "Leupeptins" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leupeptins" by people in Profiles.
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Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. Mol Cell. 2013 Mar 28; 49(6):1147-58.
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Javelaud D, van Kempen L, Alexaki VI, Le Scolan E, Luo K, Mauviel A. Efficient TGF-?/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression. Mol Cancer. 2011 Jan 06; 10(1):2.
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Hu R, Aplin AE. alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells. Pigment Cell Melanoma Res. 2010 Apr; 23(2):201-9.
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Domingo-Domènech J, Pippa R, Tápia M, Gascón P, Bachs O, Bosch M. Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. Breast Cancer Res Treat. 2008 Nov; 112(1):53-62.
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Chen J, Regan RF. Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury. Curr Neurovasc Res. 2005 Jul; 2(3):189-96.
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Torres C, Francis MK, Lorenzini A, Tresini M, Cristofalo VJ. Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts. Exp Cell Res. 2003 Nov 1; 290(2):195-206.
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Vecchione A, Marchese A, Henry P, Rotin D, Morrione A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol. 2003 May; 23(9):3363-72.