Myosin-Light-Chain Phosphatase
"Myosin-Light-Chain Phosphatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoprotein phosphatase that is specific for MYOSIN LIGHT CHAINS. It is composed of three subunits, which include a catalytic subunit, a myosin binding subunit, and a third subunit of unknown function.
| Descriptor ID |
D043263
|
| MeSH Number(s) |
D08.811.277.352.650.625.475
|
| Concept/Terms |
Myosin-Light-Chain Phosphatase- Myosin-Light-Chain Phosphatase
- Phosphatase, Myosin-Light-Chain
- Myosin Light Chain Phosphatase
- Myosin Phosphatase
- Phosphatase, Myosin
- Calponin Phosphatase
- Phosphatase, Calponin
Smooth Muscle Phosphatase-II- Smooth Muscle Phosphatase-II
- Muscle Phosphatase-II, Smooth
- Phosphatase-II, Smooth Muscle
- Smooth Muscle Phosphatase II
|
Below are MeSH descriptors whose meaning is more general than "Myosin-Light-Chain Phosphatase".
Below are MeSH descriptors whose meaning is more specific than "Myosin-Light-Chain Phosphatase".
This graph shows the total number of publications written about "Myosin-Light-Chain Phosphatase" by people in this website by year, and whether "Myosin-Light-Chain Phosphatase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 4 | 4 |
| 2004 | 2 | 1 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 3 | 2 | 5 |
| 2012 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Myosin-Light-Chain Phosphatase" by people in Profiles.
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Conaway S, Huang W, Hernandez-Lara MA, Kane MA, Penn RB, Deshpande DA. Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle. FASEB J. 2024 07 31; 38(14):e23842.
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Eto M, Katsuki S, Ohashi M, Miyagawa Y, Tanaka Y, Takeya K, Kitazawa T. Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca2+ sensitization force of smooth muscle. J Smooth Muscle Res. 2022; 58(0):22-33.
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Filter JJ, Williams BC, Eto M, Shalloway D, Goldberg ML. Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1). Elife. 2017 04 07; 6.
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Eto M, Kitazawa T. Diversity and plasticity in signaling pathways that regulate smooth muscle responsiveness: Paradigms and paradoxes for the myosin phosphatase, the master regulator of smooth muscle contraction. J Smooth Muscle Res. 2017; 53(0):1-19.
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Khasnis M, Nakatomi A, Gumpper K, Eto M. Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1. Biochemistry. 2014 Apr 29; 53(16):2701-9.
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Khromov AS, Momotani K, Jin L, Artamonov MV, Shannon J, Eto M, Somlyo AV. Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle. J Biol Chem. 2012 Jun 15; 287(25):20975-85.
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Kim JI, Urban M, Young GD, Eto M. Reciprocal regulation controlling the expression of CPI-17, a specific inhibitor protein for the myosin light chain phosphatase in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012 Jul 01; 303(1):C58-68.
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Eto M. Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem. 2009 Dec 18; 284(51):35273-7.
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Mori S, Iwaoka R, Eto M, Ohki SY. Solution structure of the inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1. Proteins. 2009 Nov 15; 77(3):732-5.
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Khromov A, Choudhury N, Stevenson AS, Somlyo AV, Eto M. Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction. J Biol Chem. 2009 Aug 07; 284(32):21569-79.