"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
|
| MeSH Number(s) |
D27.720.470.480
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 6 | 6 |
| 1997 | 0 | 10 | 10 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 7 | 7 |
| 2000 | 0 | 12 | 12 |
| 2001 | 0 | 12 | 12 |
| 2002 | 0 | 7 | 7 |
| 2003 | 2 | 21 | 23 |
| 2004 | 0 | 16 | 16 |
| 2005 | 2 | 19 | 21 |
| 2006 | 0 | 12 | 12 |
| 2007 | 0 | 16 | 16 |
| 2008 | 1 | 10 | 11 |
| 2009 | 1 | 17 | 18 |
| 2010 | 0 | 14 | 14 |
| 2011 | 0 | 14 | 14 |
| 2012 | 0 | 11 | 11 |
| 2013 | 1 | 16 | 17 |
| 2014 | 1 | 11 | 12 |
| 2015 | 0 | 10 | 10 |
| 2016 | 3 | 7 | 10 |
| 2017 | 1 | 16 | 17 |
| 2018 | 2 | 7 | 9 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 9 | 9 |
| 2022 | 0 | 4 | 4 |
| 2023 | 1 | 6 | 7 |
| 2024 | 0 | 9 | 9 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ligands" by people in Profiles.
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Golovin AV, Panteleev S, Zlobin AS, Anikeeva N, Smirnov I, Gabibov A, Sykulev Y. The role of peptide conformation presented by MHC in the induction of TCR triggering. Biophys J. 2025 Apr 01; 124(7):1073-1084.
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Naik SD, Kim M, Choi J, Kim G, Woo Kim S, Aswar VR, Tripathi SK, Gaikwad V, Yu J, Shin Jeong L. Exploring C2 and N6 Substituent Effects on Truncated 4'-Thioadenosine Derivatives as Dual A2A and A3 Adenosine Receptor Ligands. ChemMedChem. 2025 Feb 16; 20(4):e202400575.
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Cosentino G, Dichiara M, Ambrosio FA, Leotta CG, Costa G, Procopio F, Costanzo G, Raffa A, Artacho-Cord?n A, Ruiz-Cantero MC, Pasquinucci L, Marrazzo A, Pitari GM, Cobos EJ, Alcaro S, Amata E. Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds. Eur J Med Chem. 2025 Jan 05; 281:117037.
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Alugupalli KR. Characterization of Turbo, a TLR Ligand-based Adjuvant for Glycoconjugate Vaccines. Immunohorizons. 2024 08 01; 8(8):527-537.
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Kalabekova R, Quinn CM, Movellan KT, Gronenborn AM, Akke M, Polenova T. 19F Fast Magic-Angle Spinning NMR Spectroscopy on Microcrystalline Complexes of Fluorinated Ligands and the Carbohydrate Recognition Domain of Galectin-3. Biochemistry. 2024 09 03; 63(17):2207-2216.
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Alugupalli KR. A TLR4 ligand-based adjuvant for promoting the immunogenicity of typhoid subunit vaccines. Front Immunol. 2024; 15:1383476.
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Pawar K, Kawamura T, Kirino Y. The tRNAVal half: A strong endogenous Toll-like receptor 7 ligand with a 5'-terminal universal sequence signature. Proc Natl Acad Sci U S A. 2024 May 07; 121(19):e2319569121.
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Alugupalli KR. Monophosphoryl Lipid A-based Adjuvant to Promote the Immunogenicity of Multivalent Meningococcal Polysaccharide Conjugate Vaccines. Immunohorizons. 2024 04 01; 8(4):317-325.
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Battaglin F, Baca Y, Millstein J, Yang Y, Xiu J, Arai H, Wang J, Ou FS, Innocenti F, Mumenthaler SM, Jayachandran P, Kawanishi N, Lenz A, Soni S, Algaze S, Zhang W, Khoukaz T, Roussos Torres E, Seeber A, Abraham JP, Lou E, Philip PA, Weinberg BA, Shields AF, Goldberg RM, Marshall JL, Venook AP, Korn WM, Lenz HJ. CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling and clinical value. J Immunother Cancer. 2024 01 11; 12(1).
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Alugupalli KR. TLR4 Ligands in Typhoid Vi Polysaccharide Subunit Vaccines Contribute to Immunogenicity. Immunohorizons. 2024 01 01; 8(1):29-34.