"Inactivation, Metabolic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
| Descriptor ID |
D008658
|
| MeSH Number(s) |
G03.171.450 G03.787.225.450 G07.690.725.225.450
|
| Concept/Terms |
Metabolic Detoxication, Drug- Metabolic Detoxication, Drug
- Detoxication, Drug Metabolic
- Drug Metabolic Detoxication
- Drug Detoxication, Metabolic
- Detoxication, Metabolic Drug
- Metabolic Drug Detoxication
- Metabolic Detoxification, Drug
- Detoxification, Drug Metabolic
- Drug Metabolic Detoxification
- Detoxification, Drug, Metabolic
- Detoxication, Drug, Metabolic
|
Below are MeSH descriptors whose meaning is more general than "Inactivation, Metabolic".
Below are MeSH descriptors whose meaning is more specific than "Inactivation, Metabolic".
This graph shows the total number of publications written about "Inactivation, Metabolic" by people in this website by year, and whether "Inactivation, Metabolic" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inactivation, Metabolic" by people in Profiles.
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Costantino CL, Witkiewicz AK, Kuwano Y, Cozzitorto JA, Kennedy EP, Dasgupta A, Keen JC, Yeo CJ, Gorospe M, Brody JR. The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res. 2009 Jun 01; 69(11):4567-72.
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Kraft WK, Gibson E, Dysart K, Damle VS, Larusso JL, Greenspan JS, Moody DE, Kaltenbach K, Ehrlich ME. Sublingual buprenorphine for treatment of neonatal abstinence syndrome: a randomized trial. Pediatrics. 2008 Sep; 122(3):e601-7.
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Ma XL, Lopez BL, Liu GL, Christopher TA, Gao F, Guo Y, Feuerstein GZ, Ruffolo RR, Barone FC, Yue TL. Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury. Circ Res. 1997 Jun; 80(6):894-901.
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Lan SJ, Scanlan LM, Mitroka J, Weinstein SH, Lutsky BN, Free CA, Wojnar RJ, Millonig RC, Migdalof BH. Rapid metabolic inactivation of tipredane, a structurally novel topical steroid. J Steroid Biochem. 1988 Nov; 31(5):825-34.
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Abou-Donia MB, Kinnes CG, Abdo KM, Bjornsson TD. Physiological disposition and metabolism of O-ethyl-O-4-nitrophenyl phenylphosphonothioate in male cats following a single dermal administration. Drug Metab Dispos. 1983 Jan-Feb; 11(1):31-6.