Neoplastic Syndromes, Hereditary

"Neoplastic Syndromes, Hereditary" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.

Descriptor ID	D009386
MeSH Number(s)	C04.700 C16.320.700
Concept/Terms	Neoplastic Syndromes, Hereditary Neoplastic Syndromes, Hereditary Hereditary Neoplastic Syndromes Hereditary Neoplastic Syndrome Neoplastic Syndrome, Hereditary Syndrome, Hereditary Neoplastic Syndromes, Hereditary Neoplastic Hereditary Cancer Syndromes Cancer Syndrome, Hereditary Hereditary Cancer Syndrome Syndrome, Hereditary Cancer Syndromes, Hereditary Cancer Cancer Syndromes, Hereditary

Below are MeSH descriptors whose meaning is more general than "Neoplastic Syndromes, Hereditary".

Diseases [C]
Neoplasms [C04]
Neoplastic Syndromes, Hereditary [C04.700]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Neoplastic Syndromes, Hereditary [C16.320.700]

Below are MeSH descriptors whose meaning is related to "Neoplastic Syndromes, Hereditary".

Below are MeSH descriptors whose meaning is more specific than "Neoplastic Syndromes, Hereditary".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neoplastic Syndromes, Hereditary" by people in this website by year, and whether "Neoplastic Syndromes, Hereditary" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 3 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	0	1
2008	1	0	1
2010	1	0	1
2012	1	0	1
2013	1	0	1
2014	1	0	1
2015	0	1	1
2019	1	0	1
2021	3	0	3
2022	0	1	1

Below are the most recent publications written about "Neoplastic Syndromes, Hereditary" by people in Profiles.

Gheewalla GM, Luther J, Das S, Kreher JB, Scimone ER, Wong AW, Lindsay ME, Lin AE. An additional patient with SMAD4-Juvenile Polyposis-Hereditary hemorrhagic telangiectasia and connective tissue abnormalities: SMAD4 loss-of-function and gain-of-function pathogenic variants result in contrasting phenotypes. Am J Med Genet A. 2022 Oct; 188(10):3084-3088.

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Mokhashi N, Cai LZ, Shields CL, Benson WE, Ho AC. Systemic considerations with pigmented fundus lesions and retinal pigment epithelium hamartomas in Turcot syndrome. Curr Opin Ophthalmol. 2021 Nov 01; 32(6):567-573.

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Golmard L, Vasta LM, Duflos V, Corsini C, Dubois d'Enghien C, McMaster ML, Harney LA, Carr AG, Ling A, Dijoud F, Gauthier A, Miettinen M, Cost NG, Gauthier-Villars M, Orbach D, Irtan S, Haouy S, Schultz KA, Stoppa-Lyonnet D, Coupier I, Stewart DR, Sirvent N. Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome. J Med Genet. 2022 04; 59(4):346-350.

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Gomella PT, Linehan WM, Ball MW. Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management. Genes (Basel). 2021 02 11; 12(2).

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Russell BE, Rigueur D, Weaver KN, Sund K, Basil JS, Hufnagel RB, Prows CA, Oestreich A, Al-Gazali L, Hopkin RJ, Saal HM, Lyons K, Dauber A. Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features. Mol Genet Genomic Med. 2019 11; 7(11):e969.

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Wheeler KC, Warr DJ, Warsetsky SI, Barmat LI. Novel fumarate hydratase mutation in a family with atypical uterine leiomyomas and hereditary leiomyomatosis and renal cell cancer. Fertil Steril. 2016 Jan; 105(1):144-8.

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Hall MJ, Forman AD, Pilarski R, Wiesner G, Giri VN. Gene panel testing for inherited cancer risk. J Natl Compr Canc Netw. 2014 Sep; 12(9):1339-46.

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Walter AW, Ennis S, Best H, Vaughn CP, Swensen JJ, Openshaw A, Gripp KW. Constitutional mismatch repair deficiency presenting in childhood as three simultaneous malignancies. Pediatr Blood Cancer. 2013 Nov; 60(11):E135-6.

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Trufant J, Robinson M, Patel R. Brooke-Spiegler syndrome. Dermatol Online J. 2012 Dec; 18(12):16.

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Adonizio CS, Grana G, Sharan K, Rose L, Zibelli A, Miller-Samuel S, Morris GJ. Recurrent early-stage triple-negative breast cancer. Semin Oncol. 2010 Oct; 37(5):419-28.

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