"Ornithine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
| Descriptor ID |
D009955
|
| MeSH Number(s) |
D08.811.520.224.125.425
|
| Concept/Terms |
Ornithine Decarboxylase- Ornithine Decarboxylase
- Decarboxylase, Ornithine
- Ornithine Carboxy-lyase
- Carboxy-lyase, Ornithine
- Ornithine Carboxy lyase
|
Below are MeSH descriptors whose meaning is more general than "Ornithine Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Ornithine Decarboxylase".
This graph shows the total number of publications written about "Ornithine Decarboxylase" by people in this website by year, and whether "Ornithine Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ornithine Decarboxylase" by people in Profiles.
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Subhi AL, Tang B, Balsara BR, Altomare DA, Testa JR, Cooper HS, Hoffman JP, Meropol NJ, Kruger WD. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clin Cancer Res. 2004 Nov 01; 10(21):7290-6.
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Pomidor MM, Cimildoro R, Lazatin B, Zheng P, Gurr JA, Leigh IM, Jänne OA, Tuan RS, Hickok NJ. Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins. Mol Biol Cell. 1999 Dec; 10(12):4299-310.
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Pomidor MM, Ruhl KK, Zheng P, Song Y, Jänne OA, Tuan RS, Hickok NJ. Relationship between ornithine decarboxylase and cytoskeletal organization in cultured human keratinocytes: cellular responses to phorbol esters, cytochalasins, and alpha-difluoromethylornithine. Exp Cell Res. 1995 Dec; 221(2):426-37.
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Ruhl KK, Pomidor MM, Rhim JS, Tuan RS, Hickok NJ. Post-transcriptional suppression of human ornithine decarboxylase gene expression by phorbol esters in human keratinocytes. J Invest Dermatol. 1994 Nov; 103(5):687-92.
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Mao Y, Gurr JA, Hickok NJ. Retinoic acid regulates ornithine decarboxylase gene expression at the transcriptional level. Biochem J. 1993 Nov 1; 295 ( Pt 3):641-4.
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Hickok NJ, Wahlfors J, Crozat A, Halmekytö M, Alhonen L, Jänne J, Jänne OA. Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene. Gene. 1990 Sep 14; 93(2):257-63.
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Herrera-Ornelas L, Porter C, Pera P, Greco W, Petrelli NJ, Mittelman A. A comparison of ornithine decarboxylase and S-adenosylmethionine decarboxylase activity in human large bowel mucosa, polyps, and colorectal adenocarcinoma. J Surg Res. 1987 Jan; 42(1):56-60.