"Endopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
| Descriptor ID |
D010450
|
| MeSH Number(s) |
D08.811.277.656.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Endopeptidases".
Below are MeSH descriptors whose meaning is more specific than "Endopeptidases".
This graph shows the total number of publications written about "Endopeptidases" by people in this website by year, and whether "Endopeptidases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 3 | 0 | 3 |
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Below are the most recent publications written about "Endopeptidases" by people in Profiles.
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Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z. Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol. 2011 Nov 23; 18(11):1390-400.
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Bozza WP, Zhuang Z. Biochemical characterization of a multidomain deubiquitinating enzyme Ubp15 and the regulatory role of its terminal domains. Biochemistry. 2011 Jul 26; 50(29):6423-32.
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Sussman RT, Zhang XY, McMahon SB. Enzymatic assays for assessing histone deubiquitylation activity. Methods. 2011 Jul; 54(3):339-47.
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Degraff DJ, Malik M, Chen Q, Miyako K, Rejto L, Aguiar AA, Bancroft DR, Cohen P, Sikes RA. Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model. J Cell Physiol. 2007 Oct; 213(1):261-8.
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Doglio LE, Kanwar R, Jackson GR, Perez M, Avila J, Dingwall C, Dotti CG, Fortini ME, Feiguin F. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. 2006 May 4; 50(3):359-75.
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Periz G, Fortini ME. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. J Neurosci Res. 2004 Aug 1; 77(3):309-22.
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Fortini ME. Neurobiology: double trouble for neurons. Nature. 2003 Oct 9; 425(6958):565-6.
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Hu Y, Fortini ME. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol. 2003 May 26; 161(4):685-90.
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Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol. 2002 Sep; 3(9):673-84.
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Hu Y, Ye Y, Fortini ME. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell. 2002 Jan; 2(1):69-78.