Ubiquitin-Specific Proteases
"Ubiquitin-Specific Proteases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of the peptidase C19 family which regulate signal transduction by removing UBIQUITIN from specific protein substrates via a process known as deubiquitination or deubiquitylation.
| Descriptor ID |
D064570
|
| MeSH Number(s) |
D08.811.037.750 D08.811.277.656.300.887
|
| Concept/Terms |
Ubiquitin-Specific Proteases- Ubiquitin-Specific Proteases
- Proteases, Ubiquitin-Specific
- Ubiquitin Specific Proteases
- Ubiquitin-Specific Peptidases
- Peptidases, Ubiquitin-Specific
- Ubiquitin Specific Peptidases
- Ubiquitin-Specific Protease Family
- Protease Family, Ubiquitin-Specific
- Ubiquitin Specific Protease Family
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Specific Proteases".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Specific Proteases".
This graph shows the total number of publications written about "Ubiquitin-Specific Proteases" by people in this website by year, and whether "Ubiquitin-Specific Proteases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 2 | 0 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ubiquitin-Specific Proteases" by people in Profiles.
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Zhu Y, Banerjee A, Xie P, Ivanov AA, Uddin A, Jiao Q, Chi JJ, Zeng L, Lee JY, Xue Y, Lu X, Cristofanilli M, Gradishar WJ, Henry CJ, Gillespie TW, Bhave MA, Kalinsky K, Fu H, Bahar I, Zhang B, Wan Y. Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers. J Clin Invest. 2024 03 26; 134(10).
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Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr; 10(4):298-304.
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Li G, Liang Q, Gong P, Tencer AH, Zhuang Z. Activity-based diubiquitin probes for elucidating the linkage specificity of deubiquitinating enzymes. Chem Commun (Camb). 2014 Jan 07; 50(2):216-8.
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Villamil MA, Liang Q, Zhuang Z. The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention. Cell Biochem Biophys. 2013 Sep; 67(1):111-26.
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Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB. The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2). J Biol Chem. 2013 Aug 16; 288(33):24234-46.
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Villamil MA, Liang Q, Chen J, Choi YS, Hou S, Lee KH, Zhuang Z. Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1. Biochemistry. 2012 Nov 13; 51(45):9112-23.
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Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z. Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol. 2011 Nov 23; 18(11):1390-400.