Procollagen N-Endopeptidase
"Procollagen N-Endopeptidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
| Descriptor ID |
D011348
|
| MeSH Number(s) |
D08.811.277.656.300.480.664 D08.811.277.656.675.374.664
|
| Concept/Terms |
Procollagen N-Endopeptidase- Procollagen N-Endopeptidase
- Procollagen N Endopeptidase
- Procollagen N-Proteinase
- Procollagen N Proteinase
- Procollagen Peptidase
|
Below are MeSH descriptors whose meaning is more general than "Procollagen N-Endopeptidase".
Below are MeSH descriptors whose meaning is more specific than "Procollagen N-Endopeptidase".
This graph shows the total number of publications written about "Procollagen N-Endopeptidase" by people in this website by year, and whether "Procollagen N-Endopeptidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2001 | 1 | 1 | 2 |
| 2003 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Procollagen N-Endopeptidase" by people in Profiles.
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Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-?B. Am J Pathol. 2013 Jun; 182(6):2310-21.
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Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV. TNF-a and IL-1? promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem. 2011 Nov 18; 286(46):39738-49.
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Majsterek I, McAdams E, Adachi E, Dhume ST, Fertala A. Prospects and limitations of the rational engineering of fibrillar collagens. Protein Sci. 2003 Sep; 12(9):2063-72.
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Fertala A, Sieron AL, Adachi E, Jimenez SA. Collagen II containing a Cys substitution for Arg-alpha1-519: abnormal interactions of the mutated molecules with collagen IX. Biochemistry. 2001 Dec 04; 40(48):14422-8.
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Li SW, Arita M, Fertala A, Bao Y, Kopen GC, L?ngsj? TK, Hyttinen MM, Helminen HJ, Prockop DJ. Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochem J. 2001 Apr 15; 355(Pt 2):271-8.
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Arnold WV, Fertala A, Sieron AL, Hattori H, Mechling D, B?chinger HP, Prockop DJ. Recombinant procollagen II: Deletion of D period segments identifies sequences that are required for helix stabilization and generates a temperature-sensitive N-proteinase cleavage site. J Biol Chem. 1998 Nov 27; 273(48):31822-8.
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Zafarullah K, Sieron AL, Fertala A, Tromp G, Kuivaniemi H, Prockop DJ. A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C. Matrix Biol. 1997 Nov; 16(5):245-53.
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Fertala A, Sieron AL, Hojima Y, Ganguly A, Prockop DJ. Self-assembly into fibrils of collagen II by enzymic cleavage of recombinant procollagen II. Lag period, critical concentration, and morphology of fibrils differ from collagen I. J Biol Chem. 1994 Apr 15; 269(15):11584-9.