Luis Sigal

TitleProfessor
InstitutionThomas Jefferson University
DepartmentMicrobiology
Address233 S. 10th Street
Philadelphia PA 19107
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    1. Ferez M, Knudson CJ, Lev A, Wong EB, Alves-Peixoto P, Tang L, Stotesbury C, Sigal LJ. Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. J Exp Med. 2021 May 03; 218(5). PMID: 33765134.
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    2. Lu J, Li S, Li X, Zhao W, Duan X, Gu X, Xu J, Yu B, Sigal LJ, Dong Z, Xie L, Fang M. Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging. Aging Cell. 2021 Mar 29; e13353. PMID: 33780118.
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    3. Stotesbury C, Sigal LJ. Dysregulated anti-viral innate immune cascade during aging. Aging (Albany NY). 2021 01 27; 13(2):1566-1567. PMID: 33510045.
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    4. Stotesbury C, Wong EB, Tang L, Montoya B, Knudson CJ, Melo-Silva CR, Sigal LJ. Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation. Aging Cell. 2020 Jul; 19(7). PMID: 32657004.
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    5. Wilski NA, Stotesbury C, Del Casale C, Montoya B, Wong E, Sigal LJ, Snyder CM. STING Sensing of Murine Cytomegalovirus Alters the Tumor Microenvironment to Promote Antitumor Immunity. J Immunol. 2020 Apr 13. PMID: 32284333.
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    6. Stotesbury C, Alves-Peixoto P, Montoya B, Ferez M, Nair S, Snyder CM, Zhang S, Knudson CJ, Sigal LJ. a2ß1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control. J Immunol. 2020 Feb 03. PMID: 32015010.
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    7. Wong EB, Montoya B, Ferez M, Stotesbury C, Sigal LJ. Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy. PLoS Pathog. 2019 Dec 26; 15(12):e1008239. PMID: 31877196.
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    8. Alves Peixoto P, Férez M, Knudson CJ, Melo-Silva CR, Stotesbury C, Wong E, Correia Neves M, Sigal LJ. Loss of resistance to mousepox during chronic lymphocytic choriomeningitis virus infection is associated with impaired T-cell responses and can be rescued by immunization. J Virol. 2019 Dec 11. PMID: 31826990.
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    9. Wong E, Montoya B, Stotesbury C, Ferez M, Xu RH, Sigal LJ. Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node. Cell Rep. 2019 Dec 03; 29(10):3047-3059.e3. PMID: 31801072.
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    10. Alves-Peixoto P, Férez M, Knudson C, Stotesbury C, Melo-Silva CR, Wong EB, Correia-Neves M, Sigal LJ. Chronic Lymphocytic Choriomeningitis infection causes susceptibility to mousepox and impairs Natural Killer cell maturation and function. J Virol. 2019 Nov 27. PMID: 31776282.
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    11. Sigal LJ. With some risk-taking and luck: A veterinarian's adventures in viral immunology. PLoS Pathog. 2018 Jul; 14(7):e1007000. PMID: 29975767.
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    12. Wong E, Xu RH, Rubio D, Lev A, Stotesbury C, Fang M, Sigal LJ. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node. Cell Rep. 2018 Jul 03; 24(1):142-154. PMID: 29972776.
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    13. Remakus S, Ma X, Tang L, Xu RH, Knudson C, Melo-Silva CR, Rubio D, Kuo YM, Andrews A, Sigal LJ. Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts. J Immunol. 2018 Apr 11. PMID: 29643193.
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    14. Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. Cell Host Microbe. 2016 Nov 09; 20(5):674-681. PMID: 27746097.
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    15. Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, Sigal LJ. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. Immunity. 2015 Dec 15; 43(6):1148-59. PMID: 26682986.
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    16. Sigal LJ. The Pathogenesis and Immunobiology of Mousepox. Adv Immunol. 2016; 129:251-76. PMID: 26791861.
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    17. Fang M, Sigal LJ. Protective CD8+ T cell memory without help. Oncotarget. 2015 Oct 6; 6(30):28529-30. PMID: 26356572.
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    18. Gritsina G, Xiao F, O'Brien SW, Gabbasov R, Maglaty MA, Xu RH, Thapa RJ, Zhou Y, Nicolas E, Litwin S, Balachandran S, Sigal LJ, Huszar D, Connolly DC. Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. Mol Cancer Ther. 2015 Apr; 14(4):1035-47. PMID: 25646015.
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    19. Nair S, Fang M, Sigal LJ. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Ra treatment. Aging Cell. 2015 Apr; 14(2):180-90. PMID: 25399821; PMCID: PMC4364830.
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    20. Fang M, Remakus S, Roscoe F, Ma X, Sigal LJ. CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization. J Virol. 2015 Jan; 89(1):776-83. PMID: 25355885.
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    21. Siciliano NA, Hersperger AR, Lacuanan AM, Xu RH, Sidney J, Sette A, Sigal LJ, Eisenlohr LC. Impact of Distinct Poxvirus Infections on the Specificities and Functionalities of CD4+ T Cell Responses. J Virol. 2014 Sep 1; 88(17):10078-91. PMID: 24965457.
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    22. Davies ML, Sei JJ, Siciliano NA, Xu RH, Roscoe F, Sigal LJ, Eisenlohr LC, Norbury CC. MyD88-Dependent Immunity to a Natural Model of Vaccinia Virus Infection Does Not Involve Toll-Like Receptor 2. J Virol. 2014 Mar; 88(6):3557-67. PMID: 24403581.
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    23. Rubio D, Xu RH, Remakus S, Krouse TE, Truckenmiller ME, Thapa RJ, Balachandran S, Alcamí A, Norbury CC, Sigal LJ. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection. Cell Host Microbe. 2013 Jun 12; 13(6):701-10. PMID: 23768494.
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    24. Remakus S, Rubio D, Lev A, Ma X, Fang M, Xu RH, Sigal LJ. Memory CD8? T cells can outsource IFN-? production but not cytolytic killing for antiviral protection. Cell Host Microbe. 2013 May 15; 13(5):546-57. PMID: 23684306.
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    25. Smith-Garvin JE, Sigal LJ. Immunology: Memory cells sound the alarm. Nature. 2013 May 09; 497(7448):194-6. PMID: 23657346.
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    26. Ma X, Xu RH, Roscoe F, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ. The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy. J Virol. 2013 Jun; 87(12):7046-53. PMID: 23596297.
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    27. Lev A, Sigal L. Getting in front and behind the enemy lines to counter virus infection. Cell Host Microbe. 2013 Feb 13; 13(2):121-2. PMID: 23414751.
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    28. Remakus S, Sigal LJ. Memory CD8? T cell protection. Adv Exp Med Biol. 2013; 785:77-86. PMID: 23456840.
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    29. Roscoe F, Xu RH, Sigal LJ. Characterization of ectromelia virus deficient in EVM036, the homolog of vaccinia virus F13L, and its application for rapid generation of recombinant viruses. J Virol. 2012 Dec; 86(24):13501-7. PMID: 23035222.
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    30. Remakus S, Rubio D, Ma X, Sette A, Sigal LJ. Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease. J Virol. 2012 Sep; 86(18):9748-59. PMID: 22740418.
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    31. Fang M, Siciliano NA, Hersperger AR, Roscoe F, Hu A, Ma X, Shamsedeen AR, Eisenlohr LC, Sigal LJ. Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9983-8. PMID: 22665800.
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    32. Xu RH, Rubio D, Roscoe F, Krouse TE, Truckenmiller ME, Norbury CC, Hudson PN, Damon IK, Alcamí A, Sigal LJ. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver. PLoS Pathog. 2012 Jan; 8(1):e1002475. PMID: 22241999.
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    33. Remakus S, Sigal LJ. Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response. J Virol. 2011 Dec; 85(23):12578-84. PMID: 21917955.
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    34. Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ. CD94 is essential for NK cell-mediated resistance to a lethal viral disease. Immunity. 2011 Apr 22; 34(4):579-89. PMID: 21439856; PMCID: PMC3081423.
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    35. Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL. Development and function of CD94-deficient natural killer cells. PLoS One. 2010 Dec 03; 5(12):e15184. PMID: 21151939; PMCID: PMC2997080.
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    36. Fang M, Roscoe F, Sigal LJ. Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking. J Exp Med. 2010 Oct 25; 207(11):2369-81. PMID: 20876312.
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    37. Xu RH, Remakus S, Ma X, Roscoe F, Sigal LJ. Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response. PLoS Pathog. 2010 Feb 12; 6(2):e1000768. PMID: 20169189.
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    38. Fang M, Sigal L. Studying NK cell responses to ectromelia virus infections in mice. Methods Mol Biol. 2010; 612:411-28. PMID: 20033657.
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    39. Ma X, Serna A, Xu RH, Sigal LJ. The amino acid sequences flanking an antigenic determinant can strongly affect MHC class I cross-presentation without altering direct presentation. J Immunol. 2009 Apr 15; 182(8):4601-7. PMID: 19342634.
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    40. Xu RH, Cohen M, Tang Y, Lazear E, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ. The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination. J Exp Med. 2008 Apr 14; 205(4):981-92. PMID: 18391063.
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    41. MacFarlane AW, Yamazaki T, Fang M, Sigal LJ, Kurosaki T, Campbell KS. Enhanced NK-cell development and function in BCAP-deficient mice. Blood. 2008 Jul 01; 112(1):131-40. PMID: 18337558; PMCID: PMC2435684.
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    42. Fang M, Lanier LL, Sigal LJ. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLoS Pathog. 2008 Feb 8; 4(2):e30. PMID: 18266471.
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    43. Xu RH, Fang M, Klein-Szanto A, Sigal LJ. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10992-7. PMID: 17578922.
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    44. Fang M, Sigal LJ. Direct CD28 costimulation is required for CD8+ T cell-mediated resistance to an acute viral disease in a natural host. J Immunol. 2006 Dec 1; 177(11):8027-36. PMID: 17114476.
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    45. Fang M, Sigal LJ. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol. 2005 Nov 15; 175(10):6829-36. PMID: 16272340.
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    46. Fang M, Cheng H, Dai Z, Bu Z, Sigal LJ. Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host. Virology. 2006 Feb 5; 345(1):231-43. PMID: 16256161.
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    47. Ramirez MC, Sigal LJ. The multiple routes of MHC-I cross-presentation. Trends Microbiol. 2004 May; 12(5):204-7. PMID: 15120138.
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    48. Serna A, Ramirez MC, Soukhanova A, Sigal LJ. Cutting edge: efficient MHC class I cross-presentation during early vaccinia infection requires the transfer of proteasomal intermediates between antigen donor and presenting cells. J Immunol. 2003 Dec 01; 171(11):5668-72. PMID: 14634072.
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    49. Norbury CC, Sigal LJ. Cross priming or direct priming: is that really the question? Curr Opin Immunol. 2003 Feb; 15(1):82-8. PMID: 12495738.
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    50. Ramirez MC, Sigal LJ. Macrophages and dendritic cells use the cytosolic pathway to rapidly cross-present antigen from live, vaccinia-infected cells. J Immunol. 2002 Dec 15; 169(12):6733-42. PMID: 12471104.
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    51. Crotty S, Hix L, Sigal LJ, Andino R. Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection. J Gen Virol. 2002 Jul; 83(Pt 7):1707-1720. PMID: 12075090.
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