RNA Precursors

"RNA Precursors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.

Descriptor ID	D012322
MeSH Number(s)	D13.400.730 D13.444.735.640
Concept/Terms	RNA Precursors RNA Precursors Precursors, RNA RNA Precursor RNA Precursor Precursor, RNA Precursor RNA RNA, Precursor RNA, Transfer, Precursors RNA, Transfer, Precursors tRNA Precursor Precursor, tRNA Pre-tRNA Pre tRNA RNA, Ribosomal, Precursors RNA, Ribosomal, Precursors rRNA Precursor Precursor, rRNA Pre-rRNA Pre rRNA RNA, Small Nuclear, Precursors RNA, Small Nuclear, Precursors Pre-snRNA Pre snRNA snRNA Precursor Precursor, snRNA Primary RNA Transcript Primary RNA Transcript RNA Transcript, Primary Transcript, Primary RNA Primary Transcript, RNA RNA Primary Transcript Transcript, RNA Primary RNA, Messenger, Precursors RNA, Messenger, Precursors Pre-mRNA Pre mRNA mRNA Precursor Precursor, mRNA

Below are MeSH descriptors whose meaning is more general than "RNA Precursors".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acid Precursors [D13.400]
RNA Precursors [D13.400.730]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA Precursors [D13.444.735.640]

Below are MeSH descriptors whose meaning is related to "RNA Precursors".

Below are MeSH descriptors whose meaning is more specific than "RNA Precursors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA Precursors" by people in this website by year, and whether "RNA Precursors" was a major or minor topic of these publications.

Bar chart showing 17 publications over 13 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	1	0	1
2006	0	1	1
2007	1	0	1
2008	0	1	1
2009	1	1	2
2010	1	2	3
2015	2	0	2
2017	1	0	1
2020	0	1	1
2021	1	0	1
2022	0	1	1
2023	1	0	1

Below are the most recent publications written about "RNA Precursors" by people in Profiles.

Pan Y, Phillips JW, Zhang BD, Noguchi M, Kutschera E, McLaughlin J, Nesterenko PA, Mao Z, Bangayan NJ, Wang R, Tran W, Yang HT, Wang Y, Xu Y, Obusan MB, Cheng D, Lee AH, Kadash-Edmondson KE, Champhekar A, Puig-Saus C, Ribas A, Prins RM, Seet CS, Crooks GM, Witte ON, Xing Y. IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing. Proc Natl Acad Sci U S A. 2023 May 23; 120(21):e2221116120.

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Hashimoto H, Ramirez DH, Lautier O, Pawlak N, Blobel G, Palancade B, Debler EW. Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules. Sci Rep. 2022 10 21; 12(1):17691.

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Srivastava A, Ambr?sio DL, Tasak M, Gosavi U, G?nzl A. A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes. Nucleic Acids Res. 2021 12 16; 49(22):12929-12942.

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Gosavi U, Srivastava A, Badjatia N, G?nzl A. Rapid block of pre-mRNA splicing by chemical inhibition of analog-sensitive CRK9 in Trypanosoma brucei. Mol Microbiol. 2020 06; 113(6):1225-1239.

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Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Rep. 2017 01 10; 18(2):545-556.

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Boon KL, Pearson MD, Ko? M. Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. Sci Rep. 2015 Jun 15; 5:11282.

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Kim HH, Kim P, Phay M, Yoo S. Identification of precursor microRNAs within distal axons of sensory neuron. J Neurochem. 2015 Jul; 134(2):193-9.

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Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz S, Esteller M. A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell. 2010 Oct 19; 18(4):303-15.

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Song Gao J, Zhang Y, Li M, Tucker LD, Machan JT, Quesenberry P, Rigoutsos I, Ramratnam B. Atypical transcription of microRNA gene fragments. Nucleic Acids Res. 2010 May; 38(9):2775-87.

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Borden JR, Jones SW, Indurthi D, Chen Y, Papoutsakis ET. A genomic-library based discovery of a novel, possibly synthetic, acid-tolerance mechanism in Clostridium acetobutylicum involving non-coding RNAs and ribosomal RNA processing. Metab Eng. 2010 May; 12(3):268-81.

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