Sphingomyelin Phosphodiesterase
"Sphingomyelin Phosphodiesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
| Descriptor ID |
D013108
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| MeSH Number(s) |
D08.811.277.352.640.750
|
| Concept/Terms |
Sphingomyelin Phosphodiesterase- Sphingomyelin Phosphodiesterase
- Sphingomyelin Cleaving Enzyme
- Sphingomyelinase C
- Sphingomyelinase
- Sphingomyelin Cholinephosphohydrolase
|
Below are MeSH descriptors whose meaning is more general than "Sphingomyelin Phosphodiesterase".
Below are MeSH descriptors whose meaning is more specific than "Sphingomyelin Phosphodiesterase".
This graph shows the total number of publications written about "Sphingomyelin Phosphodiesterase" by people in this website by year, and whether "Sphingomyelin Phosphodiesterase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sphingomyelin Phosphodiesterase" by people in Profiles.
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Guarino AJ, Tulenko TN, Wrenn SP. Sphingomyelinase-to-LDL molar ratio determines low density lipoprotein aggregation size: biological significance. Chem Phys Lipids. 2006 Jul; 142(1-2):33-42.
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Yu BZ, Polenova T, Jain MK, Berg OG. Premicellar complexes of sphingomyelinase mediate enzyme exchange for the stationary phase turnover. Biochim Biophys Acta. 2005 Jun 30; 1712(2):137-51.
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Guarino AJ, Lee SP, Tulenko TN, Wrenn SP. Aggregation kinetics of low density lipoproteins upon exposure to sphingomyelinase. J Colloid Interface Sci. 2004 Nov 01; 279(1):109-16.
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Guarino AJ, Tulenko TN, Wrenn SP. Cholesterol crystal nucleation from enzymatically modified low-density lipoproteins: combined effect of sphingomyelinase and cholesterol esterase. Biochemistry. 2004 Feb 17; 43(6):1685-93.