T-Lymphocytes, Cytotoxic

"T-Lymphocytes, Cytotoxic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

Descriptor ID	D013602
MeSH Number(s)	A11.118.637.555.283.875 A11.118.637.555.567.550.500.200 A11.118.637.555.567.569.220.200 A11.118.637.555.567.569.500.200 A15.145.229.637.555.283.875 A15.145.229.637.555.567.550.500.200 A15.145.229.637.555.567.569.220.200 A15.145.229.637.555.567.569.500.200 A15.382.490.555.283.875 A15.382.490.555.567.550.500.200 A15.382.490.555.567.569.220.200 A15.382.490.555.567.569.500.200
Concept/Terms	T-Lymphocytes, Cytotoxic T-Lymphocytes, Cytotoxic Cytotoxic T-Lymphocyte T Lymphocytes, Cytotoxic T-Lymphocyte, Cytotoxic Cell-Mediated Lympholytic Cells Cell Mediated Lympholytic Cells Cell, Cell-Mediated Lympholytic Cell-Mediated Lympholytic Cell Cells, Cell-Mediated Lympholytic Lympholytic Cell, Cell-Mediated Lympholytic Cells, Cell-Mediated Cytotoxic T-Lymphocytes Cytotoxic T Lymphocytes TC2 Cells TC2 Cells Cell, TC2 Cells, TC2 TC2 Cell TC1 Cells TC1 Cells Cell, TC1 Cells, TC1 TC1 Cell

Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Cytotoxic".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Cytokine-Induced Killer Cells [A11.118.637.555.283]
T-Lymphocytes, Cytotoxic [A11.118.637.555.283.875]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.550.500.200]
T-Lymphocytes [A11.118.637.555.567.569]
CD8-Positive T-Lymphocytes [A11.118.637.555.567.569.220]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.220.200]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.500.200]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Cytokine-Induced Killer Cells [A15.145.229.637.555.283]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.283.875]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.550.500.200]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD8-Positive T-Lymphocytes [A15.145.229.637.555.567.569.220]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.220.200]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.500.200]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Cytokine-Induced Killer Cells [A15.382.490.555.283]
T-Lymphocytes, Cytotoxic [A15.382.490.555.283.875]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.550.500.200]
T-Lymphocytes [A15.382.490.555.567.569]
CD8-Positive T-Lymphocytes [A15.382.490.555.567.569.220]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.220.200]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.500.200]

Below are MeSH descriptors whose meaning is related to "T-Lymphocytes, Cytotoxic".

Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Cytotoxic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "T-Lymphocytes, Cytotoxic" by people in this website by year, and whether "T-Lymphocytes, Cytotoxic" was a major or minor topic of these publications.

Bar chart showing 66 publications over 23 distinct years, with a maximum of 5 publications in 2002 and 2003 and 2005 and 2008 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	2	2
1996	2	1	3
1997	1	1	2
1999	1	0	1
2002	2	3	5
2003	2	3	5
2004	3	0	3
2005	2	3	5
2006	4	0	4
2007	1	1	2
2008	5	0	5
2009	1	0	1
2010	1	2	3
2011	3	2	5
2012	2	1	3
2013	0	1	1
2014	2	1	3
2015	0	2	2
2016	1	0	1
2017	1	2	3
2021	3	0	3
2022	2	0	2
2023	1	1	2

Below are the most recent publications written about "T-Lymphocytes, Cytotoxic" by people in Profiles.

Stoffers B, Wolf H, Bacmeister L, Kupsch S, Vico T, Marchini T, Brehm MA, Yan I, Becher PM, Ardeshirdavani A, Escher F, Kim SV, Klingel K, Kirchhof P, Blankenberg S, Zeller T, Wolf D, Hilgendorf I, Westermann D, Lindner D. GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome. Nat Cardiovasc Res. 2024 01; 3(1):76-93.

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Sykulev Y. Factors contributing to the potency of CD8+ T cells. Trends Immunol. 2023 09; 44(9):693-700.

View in: PubMed
Aghayev T, Mazitova AM, Fang JR, Peshkova IO, Rausch M, Hung M, White KF, Masia R, Titerina EK, Fatkhullina AR, Cousineau I, Turcotte S, Zhigarev D, Marchenko A, Khoziainova S, Makhov P, Tan YF, Kossenkov AV, Wiest DL, Stagg J, Wang XW, Campbell KS, Dzutsev AK, Trinchieri G, Hill JA, Grivennikov SI, Koltsova EK. IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma. Cancer Discov. 2022 08 05; 12(8):1960-1983.

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Hope JL, Zhao M, Stairiker CJ, Kiernan CH, Carey AJ, Mueller YM, van Meurs M, Brouwers-Haspels I, Otero DC, Bae EA, Faso HA, Maas A, de Looper H, Fortina PM, Rigoutsos I, Bradley LM, Erkeland SJ, Katsikis PD. MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8+ T Cell Responses. J Immunol. 2022 02 01; 208(3):603-617.

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Knudson CJ, Férez M, Alves-Peixoto P, Erkes DA, Melo-Silva CR, Tang L, Snyder CM, Sigal LJ. Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation. J Virol. 2021 09 09; 95(19):e0056621.

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Gupta MP, Koenig LR, Doubrovina E, Hasan A, Dahi PB, O'Reilly RJ, Koehne G, Orlin A, Chan RVP, D'Amico DJ, Park SS, Burkholder BM, Kiss S. Ocular Outcomes after Treatment of Cytomegalovirus Retinitis Using Adoptive Immunotherapy with Cytomegalovirus-Specific Cytotoxic T Lymphocytes. Ophthalmol Retina. 2021 09; 5(9):838-849.

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Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y. Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. Pathol Res Pract. 2021 Apr; 220:153380.

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Spessott WA, Sanmillan ML, Kulkarni VV, McCormick ME, Giraudo CG. Syntaxin 4 mediates endosome recycling for lytic granule exocytosis in cytotoxic T-lymphocytes. Traffic. 2017 07; 18(7):442-452.

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Spessott WA, Sanmillan ML, McCormick ME, Kulkarni VV, Giraudo CG. SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2176-E2185.

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Katlinski KV, Gui J, Katlinskaya YV, Ortiz A, Chakraborty R, Bhattacharya S, Carbone CJ, Beiting DP, Girondo MA, Peck AR, Puré E, Chatterji P, Rustgi AK, Diehl JA, Koumenis C, Rui H, Fuchs SY. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell. 2017 Feb 13; 31(2):194-207.

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