Ravi Lokareddy

TitleInstructor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Niazi M, Florio TJ, Yang R, Lokareddy RK, Swanson NA, Gillilan RE, Cingolani G. Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation. Nucleic Acids Res. 2020 11 18; 48(20):11721-11736. PMID: 33125059.
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    2. Lokareddy RK, Ko YH, Hong N, Doll SG, Paduch M, Niederweis M, Kossiakoff AA, Cingolani G. Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment. Acta Crystallogr D Struct Biol. 2020 Sep 01; 76(Pt 9):876-888. PMID: 32876063.
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    3. Horstmann JA, Lunelli M, Cazzola H, Heidemann J, Kühne C, Steffen P, Szefs S, Rossi C, Lokareddy RK, Wang C, Lemaire L, Hughes KT, Uetrecht C, Schlüter H, Grassl GA, Stradal TEB, Rossez Y, Kolbe M, Erhardt M. Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion. Nat Commun. 2020 Apr 24; 11(1):2013. PMID: 32332720.
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    4. Cingolani G, McCauley M, Lobley A, Bryer AJ, Wesolowski J, Greco DL, Lokareddy RK, Ronzone E, Perilla JR, Paumet F. Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA. Nat Commun. 2019 06 21; 10(1):2747. PMID: 31227715.
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    5. Florio TJ, Lokareddy RK, Gillilan RE, Cingolani G. Molecular Architecture of the Inositol Phosphatase Siw14. Biochemistry. 2019 Feb 12; 58(6):534-545. PMID: 30548067.
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    6. Phillips T, Tio CW, Omerza G, Rimal A, Lokareddy RK, Cingolani G, Winter E. RNA Recognition-like Motifs Activate a Mitogen-Activated Protein Kinase. Biochemistry. 2018 Dec 18; 57(50):6878-6887. PMID: 30452242.
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    7. Rodriguez-Bravo V, Pippa R, Song WM, Carceles-Cordon M, Dominguez-Andres A, Fujiwara N, Woo J, Koh AP, Ertel A, Lokareddy RK, Cuesta-Dominguez A, Kim RS, Rodriguez-Fernandez I, Li P, Gordon R, Hirschfield H, Prats JM, Reddy EP, Fatatis A, Petrylak DP, Gomella L, Kelly WK, Lowe SW, Knudsen KE, Galsky MD, Cingolani G, Lujambio A, Hoshida Y, Domingo-Domenech J. Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Cell. 2018 Aug 23; 174(5):1200-1215.e20. PMID: 30100187.
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    8. Sankhala RS, Lokareddy RK, Begum S, Pumroy RA, Gillilan RE, Cingolani G. Three-dimensional context rather than NLS amino acid sequence determines importin a subtype specificity for RCC1. Nat Commun. 2017 Oct 17; 8(1):979. PMID: 29042532.
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    9. Wu W, Sankhala RS, Florio TJ, Zhou L, Nguyen NLT, Lokareddy RK, Cingolani G, Panté N. Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin a isoforms. Sci Rep. 2017 Sep 12; 7(1):11381. PMID: 28900157.
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    10. Motwani T, Lokareddy RK, Dunbar CA, Cortines JR, Jarrold MF, Cingolani G, Teschke CM. A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly. Sci Adv. 2017 Jul; 3(7):e1700423. PMID: 28782023.
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    11. Lokareddy RK, Sankhala RS, Roy A, Afonine PV, Motwani T, Teschke CM, Parent KN, Cingolani G. Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation. Nat Commun. 2017 Jan 30; 8:14310. PMID: 28134243.
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    12. Sankhala RS, Lokareddy RK, Cingolani G. Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J Biol Chem. 2016 May 20; 291(21):11420-33. PMID: 27033706.
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    13. Sankhala RS, Lokareddy RK, Cingolani G. A Greasy Aid to Capsid Assembly: Lessons from a Salty Virus. Structure. 2015 Oct 6; 23(10):1777-9. PMID: 26445488.
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    14. McNulty R, Lokareddy RK, Roy A, Yang Y, Lander GC, Heck AJ, Johnson JE, Cingolani G. Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. J Mol Biol. 2015 Oct 9; 427(20):3285-99. PMID: 26301600.
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    15. Sun J, Siroy A, Lokareddy RK, Speer A, Doornbos KS, Cingolani G, Niederweis M. The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD. Nat Struct Mol Biol. 2015 Sep; 22(9):672-8. PMID: 26237511.
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    16. Kralt A, Jagalur NB, van den Boom V, Lokareddy RK, Steen A, Cingolani G, Fornerod M, Veenhoff LM. Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins. Mol Biol Cell. 2015 Sep 15; 26(18):3301-12. PMID: 26179916.
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    17. Lokareddy RK, Hapsari RA, van Rheenen M, Pumroy RA, Bhardwaj A, Steen A, Veenhoff LM, Cingolani G. Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure. 2015 Jul 7; 23(7):1305-16. PMID: 26051712.
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    18. Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia. Mol Cancer Ther. 2015 Aug; 14(8):1777-93. PMID: 26026053.
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    19. Lieu KG, Shim EH, Wang J, Lokareddy RK, Tao T, Cingolani G, Zambetti GP, Jans DA. The p53-induced factor Ei24 inhibits nuclear import through an importin ß-binding-like domain. J Cell Biol. 2014 May 12; 205(3):301-12. PMID: 24821838.
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    20. Sankhala RS, Lokareddy RK, Cingolani G. Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase. Biochemistry. 2014 Feb 11; 53(5):862-71. PMID: 24447265.
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    21. Lokareddy RK, Bhardwaj A, Cingolani G. Atomic Structure of Dual-Specificity Phosphatase 26, a Novel p53 Phosphatase. Biochemistry. 2013 Feb 5; 52(5):938-48. PMID: 23298255.
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    22. Lokareddy RK, Lunelli M, Eilers B, Wolter V, Kolbe M. Combination of two separate binding domains defines stoichiometry between type III secretion system chaperone IpgC and translocator protein IpaB. J Biol Chem. 2010 Dec 17; 285(51):39965-75. PMID: 20937829.
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    23. Lunelli M, Lokareddy RK, Zychlinsky A, Kolbe M. IpaB-IpgC interaction defines binding motif for type III secretion translocator. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9661-6. PMID: 19478065.
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