Thomas Jefferson University

Eric Wickstrom

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address1020 Locust St.
Philadelphia PA 19107
Phone215-955-4578
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    EXPERIENCE
    Jefferson Medical College, Thomas Jefferson University
    1992-1996: Professor of Pharmacology; Member, Jefferson Cancer Institute
    1997-present: Professor of Microbiology & Immunology; Member, Kimmel Cancer Center; Member, Cardeza Foundation for Hematologic Research
    2002-2005: Professor of Biochemistry & Molecular Pharmacology
    2005-present: Professor of Biochemistry & Molecular Biology
    2008-present: Adjunct Professor of Radiology, College of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

    TEACHING EXPERIENCE (1992-present)
    A. Thomas Jefferson University
    Graduate: BI 515 General Biochemistry I; BI 612 Protein Function and Dysfunction; BI 614 Protein Structure and Function; BI 522 Experimental Principles in Molecular Biology; BI/PR 710,720,730 Biochemical/Pharmacological Literature Seminar; BT 411 Protein Purification and Characterization; GC 550 Foundations in Biomedical Sciences; GE 652 Molecular Basis of Cancer; PR 613 Structural Biology I; TE 521 Tissue Engineering

    UNIVERSITY, COLLEGE, AND DEPARTMENTAL COMMITTEE SERVICE (1992-present)
    Thomas Jefferson University
    Strategic Planning Working Group on Cancer and Cancer Biology, 2005-2006
    Clinical Cancer Research Review Committee, 1993-2009
    Animal Resources Committee, 1997-8
    Jefferson Medical College
    Committee on Faculty Affairs, 2004-2009
    Committee on Research, 2005-2008
    Kimmel Cancer Center
    2008-present: KCC Membership Committee
    2008-present: KCC Prostate Cancer Working Group
    2006-present: KCC Endocrine Mechanisms and Hormone Action in Cancer Program Committee
    Seminar Committee, 2005-present
    CD Facility Committee, 2000-2006
    Development Therapeutics Committee, 1997-2006
    NMR Facility Committee, 1993-2002
    Computer Committee, 1993-7
    Structural Biology Committee, 1993-7
    Biochemistry and Molecular Biology
    2007-present: Curriculum Committee (Chair, 2008-)

    INVITED LECTURES (2008-present)

    1. Genetic imaging. Center for Targeted Therapeutics and Translational Nanomedicine, University of Pennsylvania, Philadelphia, Pennsylvania, September 21, 2011.
    2. Three dimensional projection environment for molecular design and surgical simulation. US Army Telemedicine & Advanced Technology Research Center Product Line Review, Frederick, Maryland, March 29, 2011.
    3. Genetic imaging. Tinoco 80th Birthday Symposium, University of California, Berkeley, California, June 26, 2010.
    4. Molecular Designs for Diagnosis and Therapy, Department of Bioengineering, University of California, Merced, April 13, 2009.
    5. PET Imaging of Activated Cancer Gene mRNA in Tumors. New Frontiers of Science in Radiochemistry and Instrumentation for Radionuclide Imaging Workshop, Department of Energy, Bethesda, Maryland, November 5, 2008.
    6. Multiple Radionuclide Nanoparticles for Genetic Imaging. New Frontiers of Science in Radiochemistry and Instrumentation for Radionuclide Imaging Workshop, Department of Energy, Bethesda, Maryland, November 5, 2008.
    7. Scintigraphic imaging of KRAS mRNA in human pancreas cancer xenografts with ([111In]DO3A)n-poly(diamidopropanoyl)m-PNA-D(Cys-Ser-Lys-Cys) hybridization probes. Biophysical & Biomolecular Symposium: Targeted Delivery of Proteins and Nucleotides, American Chemical Society 236th Annual Meeting, Philadelphia, Pennsylvania, August 20, 2008.
    8. Multicomponent molecular detection of breast cancer cells using nanotube electronic devices specific for cell surface receptors. Emerging Technologies: Nanobiotechnology, American Chemical Society 236th Annual Meeting, Philadelphia, Pennsylvania, August 20, 2008.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Paudyal B, Zhang K, Chen CP, Wampole ME, Mehta N, Mitchell EP, Gray BD, Mattis JA, Pak KY, Thakur ML, Wickstrom E. Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA. Nucl Med Biol. 2013 Nov; 40(8):994-9. PMID: 24074944.
      Citations:    
    2. Wampole ME, Kairys JC, Mitchell EP, Ankeny ML, Thakur ML, Wickstrom E. Consistent surgeon evaluations of three-dimensional rendering of PET/CT scans of the abdomen of a patient with a ductal pancreatic mass. PLoS One. 2013; 8(9):e75237. PMID: 24086475.
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    3. Sanders JM, Wampole ME, Chen CP, Sethi D, Singh A, Dupradeau FY, Wang F, Gray BD, Thakur ML, Wickstrom E. Effects of hypoxanthine substitution in peptide nucleic acids targeting KRAS2 oncogenic mRNA molecules: theory and experiment. J Phys Chem B. 2013 Oct 03; 117(39):11584-95. PMID: 23972113.
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    4. Thakur ML, Zhang K, Berger A, Cavanaugh B, Kim S, Channappa C, Frangos AJ, Wickstrom E, Intenzo CM. VPAC1 receptors for imaging breast cancer: a feasibility study. J Nucl Med. 2013 Jul; 54(7):1019-25. PMID: 23651947.
      Citations:    
    5. Sanders JM, Wampole ME, Thakur ML, Wickstrom E. Molecular determinants of epidermal growth factor binding: a molecular dynamics study. PLoS One. 2013; 8(1):e54136. PMID: 23382875.
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    6. Thakur ML, Zhang K, Paudyal B, Devakumar D, Covarrubias MY, Chen CP, Cheng C, Gray BD, Wickstrom E, Pak KY. Targeting apoptosis for optical imaging of infection. Mol Imaging Biol. 2012 Apr; 14(2):163-71. PMID: 21538153.
      Citations:    
    7. Sethi D, Chen CP, Jing RY, Thakur ML, Wickstrom E. Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells. Bioconjug Chem. 2012 Feb 15; 23(2):158-63. PMID: 22239616.
      Citations:    
    8. Wickstrom E, Chen CP, Devadhas D, Wampole M, Jin YY, Sanders JM, Kairys JC, Ankeny ML, Hu R, Barner KE, Steiner KV, Thakur ML. Three dimensional projection environment for molecular design and surgical simulation. Stud Health Technol Inform. 2011; 163:691-5. PMID: 21335882.
      Citations:    
    9. Opitz AW, Wickstrom E, Thakur ML, Wagner NJ. Physiologically based pharmacokinetics of molecular imaging nanoparticles for mRNA detection determined in tumor-bearing mice. Oligonucleotides. 2010 Jun; 20(3):117-25. PMID: 20406142.
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    10. Amirkhanov NV, Zhang K, Aruva MR, Thakur ML, Wickstrom E. Imaging human pancreatic cancer xenografts by targeting mutant KRAS2 mRNA with [(111)In]DOTA(n)-poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) nanoparticles. Bioconjug Chem. 2010 Apr 21; 21(4):731-40. PMID: 20232877.
      Citations:    
    11. Thakur ML, Devadhas D, Zhang K, Pestell RG, Wang C, McCue P, Wickstrom E. Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products. J Nucl Med. 2010 Jan; 51(1):106-11. PMID: 20008985.
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    12. Mukherjee A, Wickstrom E, Thakur ML. Imaging oncogene expression. Eur J Radiol. 2009 May; 70(2):265-73. PMID: 19264436.
      Citations:    
    13. Amirkhanov NV, Dimitrov I, Opitz AW, Zhang K, Lackey JP, Cardi CA, Lai S, Wagner NJ, Thakur ML, Wickstrom E. Design of (Gd-DO3A)n-polydiamidopropanoyl-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agents. Biopolymers. 2008 Dec; 89(12):1061-76. PMID: 18680101.
      Citations:    
    14. Zhang K, Aruva MR, Shanthly N, Cardi CA, Rattan S, Patel C, Kim C, McCue PA, Wickstrom E, Thakur ML. PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer. J Nucl Med. 2008 Jan; 49(1):112-21. PMID: 18077536.
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    15. Tian X, Aruva MR, Zhang K, Shanthly N, Cardi CA, Thakur ML, Wickstrom E. PET imaging of CCND1 mRNA in human MCF7 estrogen receptor positive breast cancer xenografts with oncogene-specific [64Cu]chelator-peptide nucleic acid-IGF1 analog radiohybridization probes. J Nucl Med. 2007 Oct; 48(10):1699-707. PMID: 17909257.
      Citations:    
    16. Zhang K, Aruva MR, Shanthly N, Cardi CA, Patel CA, Rattan S, Cesarone G, Wickstrom E, Thakur ML. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation. Regul Pept. 2007 Dec 04; 144(1-3):91-100. PMID: 17727979.
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    17. Chakrabarti A, Zhang K, Aruva MR, Cardi CA, Opitz AW, Wagner NJ, Thakur ML, Wickstrom E. Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [(64)Cu]DO3A-peptide nucleic acid-peptide nanoparticles. Cancer Biol Ther. 2007 Jun; 6(6):948-56. PMID: 17611392.
      Citations:    
    18. Tian X, Chakrabarti A, Amirkhanov N, Aruva MR, Zhang K, Cardi CA, Lai S, Thakur ML, Wickstrom E. Receptor-mediated internalization of chelator-PNA-peptide hybridization probes for radioimaging or magnetic resonance imaging of oncogene mRNAs in tumours. Biochem Soc Trans. 2007 Feb; 35(Pt 1):72-6. PMID: 17233604.
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    19. Wickstrom E, Thakur ML. Imaging cancer gene activity in patients from outside the body. Biotechnol Healthc. 2006 Feb; 3(1):45-8. PMID: 23423635.
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    20. Tian X, Chakrabarti A, Amirkhanov NV, Aruva MR, Zhang K, Mathew B, Cardi C, Qin W, Sauter ER, Thakur ML, Wickstrom E. External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras. Ann N Y Acad Sci. 2005 Nov; 1059:106-44. PMID: 16382049.
      Citations:    
    21. Tian X, Aruva MR, Wolfe HR, Qin W, Sauter ER, Thakur ML, Waldman SA, Wickstrom E. Tumor-targeting peptide-PNA-peptide chimeras for imaging overexpressed oncogene mRNAs. Nucleosides Nucleotides Nucleic Acids. 2005; 24(5-7):1085-91. PMID: 16248097.
      Citations:    
    22. Wickstrom E, Tian X, Amirkhanov NV, Chakrabarti A, Aruva MR, Rao PS, Qin W, Zhu W, Sauter ER, Thakur ML. Radionuclide-peptide nucleic acid in diagnosis and treatment of pancreatic cancer. Methods Mol Med. 2005; 106:135-91. PMID: 15375316.
      Citations:    
    23. Tian X, Aruva MR, Qin W, Zhu W, Sauter ER, Thakur ML, Wickstrom E. Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [99mTc]peptide-peptide nucleic acid-peptide chimera. Bioconjug Chem. 2005 Jan-Feb; 16(1):70-9. PMID: 15656577.
      Citations:    
    24. Chakrabarti A, Aruva MR, Sajankila SP, Thakur ML, Wickstrom E. Synthesis of novel peptide nucleic acid-peptide chimera for non-invasive imaging of cancer. Nucleosides Nucleotides Nucleic Acids. 2005; 24(5-7):409-14. PMID: 16247960.
      Citations:    
    25. Tian X, Aruva MR, Qin W, Zhu W, Duffy KT, Sauter ER, Thakur ML, Wickstrom E. External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide-peptide nucleic acid-peptide chimeras. J Nucl Med. 2004 Dec; 45(12):2070-82. PMID: 15585484.
      Citations:    
    26. Thakur ML, Aruva MR, Gariepy J, Acton P, Rattan S, Prasad S, Wickstrom E, Alavi A. PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analog. J Nucl Med. 2004 Aug; 45(8):1381-9. PMID: 15299065.
      Citations:    
    27. Tian X, Aruva MR, Rao PS, Qin W, Read P, Sauter ER, Thakur ML, Wickstrom E. Imaging oncogene expression. Ann N Y Acad Sci. 2003 Dec; 1002:165-88. PMID: 14751834.
      Citations:    
    28. Rao PS, Tian X, Qin W, Aruva MR, Sauter ER, Thakur ML, Wickstrom E. 99mTc-peptide-peptide nucleic acid probes for imaging oncogene mRNAs in tumours. Nucl Med Commun. 2003 Aug; 24(8):857-63. PMID: 12869817.
      Citations:    
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