Short Stature Homeobox Protein
"Short Stature Homeobox Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A homeodomain protein that is highly expressed in the nuclei of skeletal muscle, bone marrow, and osteogenic cells and has critical roles in growth and development. Its gene resides within PSEUDOAUTOSOMAL REGION 1 of X and Y chromosomes and mutations are associated with several growth disorders including LERI-WEIL SYNDROME; LANGER MESOMELIC DYSPLASIA; and SHORT STATURE, IDIOPATHIC, X-LINKED.
| Descriptor ID |
D000074122
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| MeSH Number(s) |
D12.776.260.400.859
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Short Stature Homeobox Protein".
Below are MeSH descriptors whose meaning is more specific than "Short Stature Homeobox Protein".
This graph shows the total number of publications written about "Short Stature Homeobox Protein" by people in this website by year, and whether "Short Stature Homeobox Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Short Stature Homeobox Protein" by people in Profiles.
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Benito-Sanz S, Belinchon-Mart?nez A, Aza-Carmona M, de la Torre C, Huber C, Gonz?lez-Casado I, Ross JL, Thomas NS, Zinn AR, Cormier-Daire V, Heath KE. Identification of 15 novel partial SHOX deletions and 13 partial duplications, and a review of the literature reveals intron 3 to be a hotspot region. J Hum Genet. 2017 Feb; 62(2):229-234.
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Shah BC, Moran ES, Zinn AR, Pappas JG. Effect of growth hormone therapy on severe short stature and skeletal deformities in a patient with combined Turner syndrome and Langer mesomelic dysplasia. J Clin Endocrinol Metab. 2009 Dec; 94(12):5028-33.
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Campos-Barros A, Benito-Sanz S, Ross JL, Zinn AR, Heath KE. Compound heterozygosity of SHOX-encompassing and downstream PAR1 deletions results in Langer mesomelic dysplasia (LMD). Am J Med Genet A. 2007 May 01; 143A(9):933-8.
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Zinn AR, Ramos P, Ross JL. A second recombination hotspot associated with SHOX deletions. Am J Hum Genet. 2006 Mar; 78(3):523-5.
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Ross JL, Kowal K, Quigley CA, Blum WF, Cutler GB, Crowe B, Hovanes K, Elder FF, Zinn AR. The phenotype of short stature homeobox gene (SHOX) deficiency in childhood: contrasting children with Leri-Weill dyschondrosteosis and Turner syndrome. J Pediatr. 2005 Oct; 147(4):499-507.
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Ross JL, Bellus G, Scott CI, Abboudi J, Grigelioniene G, Zinn AR. Mesomelic and rhizomelic short stature: The phenotype of combined Leri-Weill dyschondrosteosis and achondroplasia or hypochondroplasia. Am J Med Genet A. 2003 Jan 01; 116A(1):61-5.
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Zinn AR, Wei F, Zhang L, Elder FF, Scott CI, Marttila P, Ross JL. Complete SHOX deficiency causes Langer mesomelic dysplasia. Am J Med Genet. 2002 Jun 15; 110(2):158-63.
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Ross JL, Scott C, Marttila P, Kowal K, Nass A, Papenhausen P, Abboudi J, Osterman L, Kushner H, Carter P, Ezaki M, Elder F, Wei F, Chen H, Zinn AR. Phenotypes Associated with SHOX Deficiency. J Clin Endocrinol Metab. 2001 Dec; 86(12):5674-80.