CDX2 Transcription Factor

"CDX2 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An antennapedia-like homeodomain transcription factor that regulates the expression of multiple genes in the INTESTINAL MUCOSA. It plays a critical role in many processes from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Descriptor ID	D000071616
MeSH Number(s)	D12.776.260.400.140 D12.776.660.201 D12.776.930.146
Concept/Terms	CDX2 Transcription Factor CDX2 Transcription Factor Homeobox Protein CDX-2 CDX-2, Homeobox Protein Homeobox Protein CDX 2 Homeobox Protein CDX2 CDX2, Homeobox Protein Caudal Type Homeo Box Transcription Factor 2 Caudal Type Homeo Box 2 Protein Transcription Factor CDX2 CDX2, Transcription Factor Cdx-2 Protein Cdx 2 Protein Cdx-3 Protein Cdx 3 Protein Cdx-2-3 Protein Cdx 2 3 Protein CDX2 Protein Caudal Type Homeobox Transcription Factor 2

Below are MeSH descriptors whose meaning is more general than "CDX2 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Homeodomain Proteins [D12.776.260.400]
CDX2 Transcription Factor [D12.776.260.400.140]
Nuclear Proteins [D12.776.660]
CDX2 Transcription Factor [D12.776.660.201]
Transcription Factors [D12.776.930]
CDX2 Transcription Factor [D12.776.930.146]

Below are MeSH descriptors whose meaning is related to "CDX2 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "CDX2 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CDX2 Transcription Factor" by people in this website by year, and whether "CDX2 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 10 publications over 10 distinct years, with a maximum of 1 publications in 2000 and 2001 and 2005 and 2006 and 2009 and 2011 and 2014 and 2016 and 2021 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	1	1
2005	0	1	1
2006	0	1	1
2009	0	1	1
2011	0	1	1
2014	0	1	1
2016	0	1	1
2021	1	0	1
2024	1	0	1

Below are the most recent publications written about "CDX2 Transcription Factor" by people in Profiles.

Kato S, Koshino A, Lasota J, Komura M, Wang C, Ebi M, Ogasawara N, Kojima K, Tsuzuki T, Kasai K, Takahashi S, Miettinen M, Kasugai K, Inaguma S. Use of SATB2 and CDX2 Immunohistochemistry to Characterize and Diagnose Colorectal Cancer. Appl Immunohistochem Mol Morphol. 2024 09 01; 32(8):362-370.

View in: PubMed
Suzuki K, Masuike Y, Mizuno R, Sachdeva UM, Chatterji P, Andres SF, Sun W, Klein-Szanto AJ, Besharati S, Remotti HE, Verzi MP, Rustgi AK. LIN28B induces a differentiation program through CDX2 in colon cancer. JCI Insight. 2021 05 10; 6(9).

View in: PubMed
Inaguma S, Lasota J, Wang Z, Felisiak-Golabek A, Ikeda H, Miettinen M. Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas. Mod Pathol. 2017 02; 30(2):278-285.

View in: PubMed
Witek ME, Snook AE, Lin JE, Blomain ES, Xiang B, Magee MS, Magee M, Waldman SA. A novel CDX2 isoform regulates alternative splicing. PLoS One. 2014; 9(8):e104293.

View in: PubMed
Watts JA, Zhang C, Klein-Szanto AJ, Kormish JD, Fu J, Zhang MQ, Zaret KS. Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development. PLoS Genet. 2011 Sep; 7(9):e1002277.

View in: PubMed
Winn B, Tavares R, Matoso A, Noble L, Fanion J, Waldman SA, Resnick MB. Expression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas. Hum Pathol. 2010 Jan; 41(1):123-8.

View in: PubMed
Debruyne PR, Witek M, Gong L, Birbe R, Chervoneva I, Jin T, Domon-Cell C, Palazzo JP, Freund JN, Li P, Pitari GM, Schulz S, Waldman SA. Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells. Gastroenterology. 2006 Apr; 130(4):1191-206.

View in: PubMed
Witek ME, Nielsen K, Walters R, Hyslop T, Palazzo J, Schulz S, Waldman SA. The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin Cancer Res. 2005 Dec 15; 11(24 Pt 1):8549-56.

View in: PubMed
Di Guglielmo MD, Park J, Schulz S, Waldman SA. Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C. FEBS Lett. 2001 Oct 26; 507(2):128-32.

View in: PubMed
Park J, Schulz S, Waldman SA. Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx2. Gastroenterology. 2000 Jul; 119(1):89-96.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement