PAX3 Transcription Factor
"PAX3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A paired box transcription factor that functions in CELL PROLIFERATION; CELL MIGRATION; and APOPTOSIS. It also is involved in MYOGENESIS and neural development. Mutations in the PAX3 gene are associated with WAARDENBURG SYNDROME TYPE 1.
| Descriptor ID |
D000072041
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| MeSH Number(s) |
D12.776.260.645.782 D12.776.930.700.782
|
| Concept/Terms |
PAX3 Transcription Factor- PAX3 Transcription Factor
- Transcription Factor, PAX3
- Paired Box Transcription Factor 3
- Transcription Factor PAX3
- Factor PAX3, Transcription
- PAX3, Transcription Factor
- Paired Box 3 Protein
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Below are MeSH descriptors whose meaning is more general than "PAX3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "PAX3 Transcription Factor".
This graph shows the total number of publications written about "PAX3 Transcription Factor" by people in this website by year, and whether "PAX3 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 3 | 3 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "PAX3 Transcription Factor" by people in Profiles.
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Ayyanathan K, Peng H, Hou Z, Fredericks WJ, Goyal RK, Langer EM, Longmore GD, Rauscher FJ. The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Cancer Res. 2007 Oct 1; 67(19):9097-106.
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Fredericks WJ, Ayyanathan K, Rauscher FJ. Regulating the neoplastic phenotype using engineered transcriptional repressors. Cancer Lett. 2001 Jan; 162 Suppl:S23-S32.
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Ayyanathan K, Fredericks WJ, Berking C, Herlyn M, Balakrishnan C, Gunther E, Rauscher FJ. Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. Cancer Res. 2000 Oct 15; 60(20):5803-14.
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Fredericks WJ, Ayyanathan K, Herlyn M, Friedman JR, Rauscher FJ. An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene. Mol Cell Biol. 2000 Jul; 20(14):5019-31.
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Reeves FC, Burdge GC, Fredericks WJ, Rauscher FJ, Lillycrop KA. Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF. J Cell Sci. 1999 Jan; 112 ( Pt 2):253-61.
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Reeves FC, Fredericks WJ, Rauscher FJ, Lillycrop KA. The DNA binding activity of the paired box transcription factor Pax-3 is rapidly downregulated during neuronal cell differentiation. FEBS Lett. 1998 Jan 23; 422(1):118-22.
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Bernasconi M, Remppis A, Fredericks WJ, Rauscher FJ, Schäfer BW. Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13164-9.
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Scheidler S, Fredericks WJ, Rauscher FJ, Barr FG, Vogt PK. The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. Proc Natl Acad Sci U S A. 1996 Sep 3; 93(18):9805-9.
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Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang XP, Neilson EG, Rauscher FJ. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev. 1996 Aug 15; 10(16):2067-78.
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Bennicelli JL, Fredericks WJ, Wilson RB, Rauscher FJ, Barr FG. Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains. Oncogene. 1995 Jul 6; 11(1):119-30.