beta-Arrestins

"beta-Arrestins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

Descriptor ID	D000071557
MeSH Number(s)	D12.644.360.024.098.525 D12.776.157.057.005.525 D12.776.476.024.104.525 D12.776.543.090.525
Concept/Terms	beta-Arrestins beta-Arrestins beta Arrestins beta-Arrestin beta Arrestin

Below are MeSH descriptors whose meaning is more general than "beta-Arrestins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Arrestins [D12.644.360.024.098]
beta-Arrestins [D12.644.360.024.098.525]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Arrestins [D12.776.157.057.005]
beta-Arrestins [D12.776.157.057.005.525]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Arrestins [D12.776.476.024.104]
beta-Arrestins [D12.776.476.024.104.525]
Membrane Proteins [D12.776.543]
Arrestins [D12.776.543.090]
beta-Arrestins [D12.776.543.090.525]

Below are MeSH descriptors whose meaning is related to "beta-Arrestins".

Below are MeSH descriptors whose meaning is more specific than "beta-Arrestins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta-Arrestins" by people in this website by year, and whether "beta-Arrestins" was a major or minor topic of these publications.

Bar chart showing 28 publications over 18 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	2	2
1999	0	2	2
2001	0	1	1
2007	0	1	1
2008	0	2	2
2009	0	3	3
2010	0	2	2
2011	0	1	1
2013	0	2	2
2014	0	1	1
2015	0	1	1
2016	0	1	1
2017	1	0	1
2018	1	0	1
2021	1	1	2
2022	0	2	2
2023	0	1	1

Below are the most recent publications written about "beta-Arrestins" by people in Profiles.

Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL. Identification of a ?-arrestin-biased negative allosteric modulator for the ?2-adrenergic receptor. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2302668120.

View in: PubMed
Shah SD, Lind C, De Pascali F, Penn RB, MacKerell AD, Deshpande DA. In silico identification of a ?2-adrenoceptor allosteric site that selectively augments canonical ?2AR-Gs signaling and function. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2214024119.

View in: PubMed
De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, Benovic JL. ?2 -Adrenoceptor agonist profiling reveals biased signalling phenotypes for the ?2 -adrenoceptor with possible implications for the treatment of asthma. Br J Pharmacol. 2022 10; 179(19):4692-4708.

View in: PubMed
Luo J, De Pascali F, Richmond GW, Khojah AM, Benovic JL. Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4. J Biol Chem. 2022 02; 298(2):101551.

View in: PubMed
Ippolito M, De Pascali F, Inoue A, Benovic JL. Phenylalanine 193 in Extracellular Loop 2 of the ?2-Adrenergic Receptor Coordinates ?-Arrestin Interaction. Mol Pharmacol. 2022 02; 101(2):87-94.

View in: PubMed
Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG. Pepducin-mediated cardioprotection via ?-arrestin-biased ?2-adrenergic receptor-specific signaling. Theranostics. 2018; 8(17):4664-4678.

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Luo J, Busillo JM, Stumm R, Benovic JL. G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ?-Arrestin. Mol Pharmacol. 2017 06; 91(6):554-566.

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Carr R, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL. ?-arrestin-biased signaling through the ?2-adrenergic receptor promotes cardiomyocyte contraction. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):E4107-16.

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Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. FASEB J. 2015 Oct; 29(10):4227-35.

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Tian X, Kang DS, Benovic JL. ?-arrestins and G protein-coupled receptor trafficking. Handb Exp Pharmacol. 2014; 219:173-86.

View in: PubMed

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