Signaling Lymphocytic Activation Molecule Family
"Signaling Lymphocytic Activation Molecule Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
| Descriptor ID |
D000071176
|
| MeSH Number(s) |
D12.776.395.550.736 D12.776.543.550.746 D12.776.543.750.705.970
|
| Concept/Terms |
Signaling Lymphocytic Activation Molecule Family- Signaling Lymphocytic Activation Molecule Family
- Signaling Lymphocytic Activation Molecule Receptors
- SLAMF Receptors
- Signaling Lymphocytic Activation Molecule Family Receptors
- Signaling Lymphocytic Activation Molecules
- SLAM Family Receptors
|
Below are MeSH descriptors whose meaning is more general than "Signaling Lymphocytic Activation Molecule Family".
Below are MeSH descriptors whose meaning is more specific than "Signaling Lymphocytic Activation Molecule Family".
This graph shows the total number of publications written about "Signaling Lymphocytic Activation Molecule Family" by people in this website by year, and whether "Signaling Lymphocytic Activation Molecule Family" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Signaling Lymphocytic Activation Molecule Family" by people in Profiles.
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Pazina T, James AM, Colby KB, Yang Y, Gale A, Jhatakia A, Kearney AY, Graziano RF, Bezman NA, Robbins MD, Cohen AD, Campbell KS. Enhanced SLAMF7 Homotypic Interactions by Elotuzumab Improves NK Cell Killing of Multiple Myeloma. Cancer Immunol Res. 2019 10; 7(10):1633-1646.
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Campbell KS, Cohen AD, Pazina T. Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma. Front Immunol. 2018; 9:2551.
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Wong EB, Soni C, Chan AY, Domeier PP, Abraham T, Limaye N, Khan TN, Elias MJ, Chodisetti SB, Wakeland EK, Rahman ZS. B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. J Immunol. 2015 May 01; 194(9):4130-43.
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Hu T, Gimferrer I, Simmons A, Wiest D, Alberola-Ila J. The Ras/MAPK pathway is required for generation of iNKT cells. PLoS One. 2011 May 10; 6(5):e19890.
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Brando C, Mukhopadhyay S, Kovacs E, Medina R, Patel P, Catina TL, Campbell KS, Santoli D. Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104. J Leukoc Biol. 2005 Aug; 78(2):359-71.