Valosin Containing Protein

"Valosin Containing Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.

Descriptor ID	D000074405
MeSH Number(s)	D08.811.277.040.013.500.750 D08.811.277.040.025.024.750 D12.776.157.025.750.750 D12.776.167.800
Concept/Terms	Valosin Containing Protein Valosin Containing Protein Cell Cycle Protein CDC48 Valosine-Containing Protein Valosine Containing Protein p97 Valosin-Containing Protein Valosin-Containing Protein, p97 p97 Valosin Containing Protein Valosin-Containing Protein CDC48 Protein Cell Cycle Protein CDC48p

Below are MeSH descriptors whose meaning is more general than "Valosin Containing Protein".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
AAA Proteins [D08.811.277.040.013]
ATPases Associated with Diverse Cellular Activities [D08.811.277.040.013.500]
Valosin Containing Protein [D08.811.277.040.013.500.750]
Adenosine Triphosphatases [D08.811.277.040.025]
ATPases Associated with Diverse Cellular Activities [D08.811.277.040.025.024]
Valosin Containing Protein [D08.811.277.040.025.024.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
AAA Proteins [D12.776.157.025]
ATPases Associated with Diverse Cellular Activities [D12.776.157.025.750]
Valosin Containing Protein [D12.776.157.025.750.750]
Cell Cycle Proteins [D12.776.167]
Valosin Containing Protein [D12.776.167.800]

Below are MeSH descriptors whose meaning is more specific than "Valosin Containing Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Valosin Containing Protein" by people in this website by year, and whether "Valosin Containing Protein" was a major or minor topic of these publications.

Bar chart showing 3 publications over 2 distinct years, with a maximum of 2 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2016	0	1	1
2022	0	2	2

Below are the most recent publications written about "Valosin Containing Protein" by people in Profiles.

Lehner MH, Walker J, Temcinaite K, Herlihy A, Taschner M, Berger AC, Corbett AH, Dirac Svejstrup AB, Svejstrup JQ. Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Rep. 2022 10 25; 41(4):111536.

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Ferrari V, Cristofani R, Cicardi ME, Tedesco B, Crippa V, Chierichetti M, Casarotto E, Cozzi M, Mina F, Galbiati M, Piccolella M, Carra S, Vaccari T, Nalbandian A, Kimonis V, Fortuna TR, Pandey UB, Gagliani MC, Cortese K, Rusmini P, Poletti A. Pathogenic variants of Valosin-containing protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells. Neuropathol Appl Neurobiol. 2022 08; 48(5):e12818.

View in: PubMed
van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H. VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell. 2016 10 06; 64(1):189-198.

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McCluskey L, Vandriel S, Elman L, Van Deerlin VM, Powers J, Boller A, Wood EM, Woo J, McMillan CT, Rascovsky K, Grossman M. ALS-Plus syndrome: non-pyramidal features in a large ALS cohort. J Neurol Sci. 2014 Oct 15; 345(1-2):118-24.

View in: PubMed
Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurr? MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G, Galassi G, Scholz SW, Taylor JP, Restagno G, Chi? A, Traynor BJ. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010 Dec 09; 68(5):857-64.

View in: PubMed

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