Anaphase-Promoting Complex-Cyclosome
"Anaphase-Promoting Complex-Cyclosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.
| Descriptor ID |
D064173
|
| MeSH Number(s) |
D08.811.464.938.750.092 D12.776.167.024
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Anaphase-Promoting Complex-Cyclosome".
Below are MeSH descriptors whose meaning is more specific than "Anaphase-Promoting Complex-Cyclosome".
- Anaphase-Promoting Complex-Cyclosome
- Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
- Cdc20 Proteins
- Cdh1 Proteins
This graph shows the total number of publications written about "Anaphase-Promoting Complex-Cyclosome" by people in this website by year, and whether "Anaphase-Promoting Complex-Cyclosome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Anaphase-Promoting Complex-Cyclosome" by people in Profiles.
-
Rimal A, Kamdar ZP, Tio CW, Winter E. Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase. Mol Cell Biol. 2020 07 29; 40(16).
-
Li F, Mladenov E, Mortoga S, Iliakis G. SCFSKP2 regulates APC/CCDH1-mediated degradation of CTIP to adjust DNA-end resection in G2-phase. Cell Death Dis. 2020 07 18; 11(7):548.
-
Lee SJ, Rodriguez-Bravo V, Kim H, Datta S, Foley EA. The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis. J Cell Sci. 2017 05 15; 130(10):1760-1771.
-
Bott LC, Salomons FA, Maric D, Liu Y, Merry D, Fischbeck KH, Dantuma NP. The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex. Sci Rep. 2016 06 17; 6:27703.