Enhancer of Zeste Homolog 2 Protein

"Enhancer of Zeste Homolog 2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation at the PROMOTER REGIONS of the circadian genes and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.

Descriptor ID	D000071221
MeSH Number(s)	D05.500.781.750.250 D08.811.913.555.500.800.400.500.500 D12.776.660.235.600.200.250 D12.776.664.235.800.200.250 D12.776.930.780.890.200.250
Concept/Terms	Enhancer of Zeste Homolog 2 Protein Enhancer of Zeste Homolog 2 Protein Lysine N-Methyltransferase-6 Lysine N Methyltransferase 6 Histone-Lysine N-Methyltransferase EZH2 EZH2, Histone-Lysine N-Methyltransferase Histone Lysine N Methyltransferase EZH2 Enhancer of Zeste Homolog 2

Below are MeSH descriptors whose meaning is more general than "Enhancer of Zeste Homolog 2 Protein".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Polycomb-Group Proteins [D05.500.781]
Polycomb Repressive Complex 2 [D05.500.781.750]
Enhancer of Zeste Homolog 2 Protein [D05.500.781.750.250]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
One-Carbon Group Transferases [D08.811.913.555]
Methyltransferases [D08.811.913.555.500]
Protein Methyltransferases [D08.811.913.555.500.800]
Histone-Lysine N-Methyltransferase [D08.811.913.555.500.800.400]
Polycomb Repressive Complex 2 [D08.811.913.555.500.800.400.500]
Enhancer of Zeste Homolog 2 Protein [D08.811.913.555.500.800.400.500.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nuclear Proteins [D12.776.660]
Chromosomal Proteins, Non-Histone [D12.776.660.235]
Polycomb-Group Proteins [D12.776.660.235.600]
Polycomb Repressive Complex 2 [D12.776.660.235.600.200]
Enhancer of Zeste Homolog 2 Protein [D12.776.660.235.600.200.250]
Nucleoproteins [D12.776.664]
Chromosomal Proteins, Non-Histone [D12.776.664.235]
Polycomb-Group Proteins [D12.776.664.235.800]
Polycomb Repressive Complex 2 [D12.776.664.235.800.200]
Enhancer of Zeste Homolog 2 Protein [D12.776.664.235.800.200.250]
Transcription Factors [D12.776.930]
Repressor Proteins [D12.776.930.780]
Polycomb-Group Proteins [D12.776.930.780.890]
Polycomb Repressive Complex 2 [D12.776.930.780.890.200]
Enhancer of Zeste Homolog 2 Protein [D12.776.930.780.890.200.250]

Below are MeSH descriptors whose meaning is related to "Enhancer of Zeste Homolog 2 Protein".

Below are MeSH descriptors whose meaning is more specific than "Enhancer of Zeste Homolog 2 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Enhancer of Zeste Homolog 2 Protein" by people in this website by year, and whether "Enhancer of Zeste Homolog 2 Protein" was a major or minor topic of these publications.

Bar chart showing 10 publications over 8 distinct years, with a maximum of 2 publications in 2013 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	1	1
2011	0	1	1
2013	0	2	2
2016	1	0	1
2018	1	0	1
2019	0	1	1
2020	2	0	2
2022	1	0	1

Below are the most recent publications written about "Enhancer of Zeste Homolog 2 Protein" by people in Profiles.

Puzyrenko A, Kumar SN, Pantazis CG, Iczkowski KA. Inverse co-expression of EZH2 and acetylated H3K27 in prostatic tissue. Ann Diagn Pathol. 2022 Aug; 59:151956.

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Wasson CW, Abignano G, Hermes H, Malaab M, Ross RL, Jimenez SA, Chang HY, Feghali-Bostwick CA, Del Galdo F. Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH. Ann Rheum Dis. 2020 04; 79(4):507-517.

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Karakashev S, Fukumoto T, Zhao B, Lin J, Wu S, Fatkhutdinov N, Park PH, Semenova G, Jean S, Cadungog MG, Borowsky ME, Kossenkov AV, Liu Q, Zhang R. EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. Cancer Cell. 2020 02 10; 37(2):157-167.e6.

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Lu C, Sidoli S, Kulej K, Ross K, Wu CH, Garcia BA. Coordination between TGF-? cellular signaling and epigenetic regulation during epithelial to mesenchymal transition. Epigenetics Chromatin. 2019 02 08; 12(1):11.

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Ding Q, Wang Y, Zuo Z, Gong Y, Krishnamurthy S, Li CW, Lai YJ, Wei W, Wang J, Manyam GC, Diao L, Zhang X, Lin F, Symmans WF, Sun L, Liu CG, Liu X, Debeb BG, Ueno NT, Harano K, Alvarez RH, Wu Y, Cristofanilli M, Huo L. Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer. Hum Pathol. 2018 07; 77:121-129.

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Avedschmidt SE, Stagner AM, Eagle RC, Harocopos GJ, Dou Y, Rao RC. The Targetable Epigenetic Tumor Protein EZH2 is Enriched in Intraocular Medulloepithelioma. Invest Ophthalmol Vis Sci. 2016 11 01; 57(14):6242-6246.

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Mu Z, Li H, Fernandez SV, Alpaugh KR, Zhang R, Cristofanilli M. EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells. J Exp Clin Cancer Res. 2013 Sep 27; 32:70.

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Knudsen ES, Dervishaj O, Kleer CG, Pajak T, Schwartz GF, Witkiewicz AK. EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer. Cell Cycle. 2013 Jul 01; 12(13):2042-50.

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Gong Y, Huo L, Liu P, Sneige N, Sun X, Ueno NT, Lucci A, Buchholz TA, Valero V, Cristofanilli M. Polycomb group protein EZH2 is frequently expressed in inflammatory breast cancer and is predictive of worse clinical outcome. Cancer. 2011 Dec 15; 117(24):5476-84.

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Toll AD, Dasgupta A, Potoczek M, Yeo CJ, Kleer CG, Brody JR, Witkiewicz AK. Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma. Hum Pathol. 2010 Sep; 41(9):1205-9.

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