Genetic Therapy

"Genetic Therapy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

Descriptor ID	D015316
MeSH Number(s)	E02.095.301 E05.393.420.301
Concept/Terms	Genetic Therapy Genetic Therapy Genetic Therapies Therapies, Genetic Therapy, Genetic Therapy, DNA DNA Therapy Genetic Therapy, Somatic Genetic Therapy, Somatic Genetic Therapies, Somatic Somatic Genetic Therapies Somatic Genetic Therapy Therapies, Somatic Genetic Therapy, Somatic Genetic Genetic Therapy, Gametic Genetic Therapy, Gametic Gametic Genetic Therapies Gametic Genetic Therapy Genetic Therapies, Gametic Therapies, Gametic Genetic Therapy, Gametic Genetic Gene Therapy Gene Therapy Therapy, Gene Gene Therapy, Somatic Gene Therapy, Somatic Therapy, Somatic Gene Somatic Gene Therapy

Below are MeSH descriptors whose meaning is more general than "Genetic Therapy".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Biological Therapy [E02.095]
Genetic Therapy [E02.095.301]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Genetic Therapy [E05.393.420.301]

Below are MeSH descriptors whose meaning is more specific than "Genetic Therapy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genetic Therapy" by people in this website by year, and whether "Genetic Therapy" was a major or minor topic of these publications.

Bar chart showing 414 publications over 30 distinct years, with a maximum of 24 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	3	5	8
1997	7	1	8
1998	6	3	9
1999	8	0	8
2000	10	3	13
2001	10	7	17
2002	13	9	22
2003	16	8	24
2004	11	9	20
2005	14	4	18
2006	11	5	16
2007	20	2	22
2008	11	2	13
2009	9	4	13
2010	11	7	18
2011	17	6	23
2012	11	3	14
2013	10	5	15
2014	8	6	14
2015	7	6	13
2016	4	5	9
2017	12	1	13
2018	8	5	13
2019	5	9	14
2020	5	6	11
2021	10	4	14
2022	2	6	8
2023	0	6	6
2024	7	9	16
2025	2	0	2

Below are the most recent publications written about "Genetic Therapy" by people in Profiles.

Wang J, Poskitt LE, Gallagher J, Puffenberger EG, Wynn RM, Shishodia G, Chuang DT, Beever J, Hardin DL, Brigatti KW, Baker WC, Gately R, Bertrand S, Rodrigues A, Benatti HR, Taghian T, Hall E, Prestigiacomo R, Liang J, Chen G, Zhou X, Ren L, Liu N, He R, Su Q, Xie J, Jiang Z, Gruntman A, Gray-Edwards H, Gao G, Strauss KA, Wang D. BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease. Sci Transl Med. 2025 Feb 26; 17(787):eads0539.

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Yu-Wai-Man P, Newman NJ, Biousse V, Carelli V, Moster ML, Vignal-Clermont C, Klopstock T, Sadun AA, Sergott RC, Hage R, Degli Esposti S, La Morgia C, Priglinger C, Karanja R, Taiel M, Sahel JA. Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy. JAMA Ophthalmol. 2025 Feb 01; 143(2):99-108.

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Van Linthout S, Stellos K, Giacca M, Bertero E, Cannata A, Carrier L, Garcia-Pavia P, Ghigo A, Gonz?lez A, Haugaa KH, Imazio M, Lopes LR, Most P, Pollesello P, Schunkert H, Streckfuss-B?meke K, Thum T, Tocchetti CG, Tsch?pe C, van der Meer P, van Rooij E, Metra M, Rosano GMC, Heymans S. State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases. Eur J Heart Fail. 2025 Jan; 27(1):5-25.

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Goldenberg M, Lanzkron S, Pecker LH. Late effects of hemopoietic stem cell transplant for sickle cell disease: monitoring and management. Expert Rev Hematol. 2024 Dec; 17(12):891-905.

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Herre?o-Pach?n AM, Sawamoto K, Stapleton M, Khan S, Piechnik M, ?lvarez JV, Tomatsu S. Adeno-Associated Virus Gene Transfer Ameliorates Progression of Skeletal Lesions in Mucopolysaccharidosis IVA Mice. Hum Gene Ther. 2024 Dec; 35(23-24):955-968.

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Celik B, Rintz E, Sansanwal N, Khan S, Bigger B, Tomatsu S. Lentiviral Vector-Mediated Ex Vivo Hematopoietic Stem Cell Gene Therapy for Mucopolysaccharidosis IVA Murine Model. Hum Gene Ther. 2024 Nov; 35(21-22):917-937.

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Celik B, Leal AF, Tomatsu S. Potential Targeting Mechanisms for Bone-Directed Therapies. Int J Mol Sci. 2024 Jul 30; 25(15).

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Lerchenm?ller C, Hastings MH, Rabolli CP, Betge F, Roshan M, Liu LX, Liu X, He? C, Roh JD, Platt C, Bezzerides V, Busch M, Katus HA, Frey N, Most P, Rosenzweig A. CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice. Mol Ther. 2024 Oct 02; 32(10):3683-3694.

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Wheeler S, Mahmoudzadeh R, Randolph J. Treatment for dry age-related macular degeneration: where we stand in 2024. Curr Opin Ophthalmol. 2024 Sep 01; 35(5):359-364.

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Matesanz SE, Brigatti KW, Young M, Yum SW, Strauss KA. Preemptive dual therapy for children at risk for infantile-onset spinal muscular atrophy. Ann Clin Transl Neurol. 2024 Jul; 11(7):1868-1878.

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