Protein Engineering

"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.

Descriptor ID	D015202
MeSH Number(s)	E05.393.420.601
Concept/Terms	Protein Engineering Protein Engineering Engineering, Protein Genetic Engineering, Protein Engineering, Protein Genetic Protein Genetic Engineering Proteins, Genetic Engineering Genetic Engineering of Proteins

Below are MeSH descriptors whose meaning is more general than "Protein Engineering".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Protein Engineering [E05.393.420.601]

Below are MeSH descriptors whose meaning is related to "Protein Engineering".

Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.

Bar chart showing 34 publications over 17 distinct years, with a maximum of 4 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	1	1
2002	0	1	1
2003	2	0	2
2004	2	2	4
2005	2	1	3
2006	0	1	1
2007	0	1	1
2008	1	1	2
2009	1	2	3
2010	0	1	1
2012	0	3	3
2013	2	0	2
2014	1	2	3
2017	1	1	2
2018	1	0	1
2020	1	2	3

Below are the most recent publications written about "Protein Engineering" by people in Profiles.

Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28046-28055.

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Van Rompay KKA, Coffey LL, Kapoor T, Gazumyan A, Keesler RI, Jurado A, Peace A, Agudelo M, Watanabe J, Usachenko J, Singapuri A, Immareddy R, Ardeshir A, Stuart JB, Bournazos S, Ravetch JV, Balderes PJ, Lorenz IC, Esswein SR, Keeffe JR, Bjorkman PJ, Wang Q, Rice CM, MacDonald MR, Nussenzweig MC, Robbiani DF. A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7981-7989.

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Vernet E, Pedersen M?, Th?gersen H, Shaw AC. Engineering Xaa-Pro dipeptidyl aminopeptidase for specific cleavage of glucagon and glucagon-like peptide 1 from fusion proteins. Protein Expr Purif. 2020 06; 170:105590.

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Giddens JP, Lomino JV, DiLillo DJ, Ravetch JV, Wang LX. Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):12023-12027.

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Chen TF, Sazinsky SL, Houde D, DiLillo DJ, Bird J, Li KK, Cheng GT, Qiu H, Engen JR, Ravetch JV, Wittrup KD. Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs. J Mol Biol. 2017 08 04; 429(16):2528-2541.

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Li T, DiLillo DJ, Bournazos S, Giddens JP, Ravetch JV, Wang LX. Modulating IgG effector function by Fc glycan engineering. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):3485-3490.

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Oldenburg J, Albert T. Novel products for haemostasis - current status. Haemophilia. 2014 May; 20 Suppl 4:23-8.

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Bhardwaj A, Casjens SR, Cingolani G. Exploring the atomic structure and conformational flexibility of a 320 ? long engineered viral fiber using X-ray crystallography. Acta Crystallogr D Biol Crystallogr. 2014 Feb; 70(Pt 2):342-53.

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Bournazos S, Chow SK, Abboud N, Casadevall A, Ravetch JV. Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity. J Clin Invest. 2014 Feb; 124(2):725-9.

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Albertsen L, Shaw AC, Norrild JC, Str?mgaard K. Recombinant production of peptide C-terminal a-amides using an engineered intein. Bioconjug Chem. 2013 Nov 20; 24(11):1883-94.

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