"Gene Products, tat" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.
| Descriptor ID |
D015696
|
| MeSH Number(s) |
D12.776.260.755.199 D12.776.930.900.199 D12.776.964.925.984.400
|
| Concept/Terms |
Gene Products, tat- Gene Products, tat
- tat Gene Products
- tat Protein
- Gene Product, tat
- tat Gene Product
|
Below are MeSH descriptors whose meaning is more general than "Gene Products, tat".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, tat".
This graph shows the total number of publications written about "Gene Products, tat" by people in this website by year, and whether "Gene Products, tat" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 3 | 3 |
| 2003 | 2 | 0 | 2 |
| 2004 | 2 | 0 | 2 |
| 2006 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Products, tat" by people in Profiles.
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Ildefonso CJ, Jaime H, Rahman MM, Li Q, Boye SE, Hauswirth WW, Lucas AR, McFadden G, Lewin AS. Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation. Hum Gene Ther. 2015 Jan; 26(1):59-68.
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Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, Karn J. Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency. J Virol. 2008 Dec; 82(24):12291-303.
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Agrawal L, Louboutin JP, Strayer DS. Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implications. Virology. 2007 Jul 5; 363(2):462-72.
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Dammeyer P, Jaramillo MC, Pipes BL, Badowski MS, Tsang TC, Harris DT. Heat-inducible amplifier vector for high-level expression of granulocyte-macrophage colony-stimulating factor. Int J Hyperthermia. 2006 Aug; 22(5):407-19.
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Brailoiu E, Brailoiu GC, Mameli G, Dolei A, Sawaya BE, Dun NJ. Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca(2+) overload and neuronal death in cultured rat cortical neurons. J Neurovirol. 2006 Feb; 12(1):17-24.
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Argyris EG, Kulkosky J, Meyer ME, Xu Y, Mukhtar M, Pomerantz RJ, Williams KJ. The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity. Virology. 2004 Dec 20; 330(2):481-6.
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Farrell CJ, Lee JM, Shin EC, Cebrat M, Cole PA, Hayward SD. Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4625-30.
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De Falco G, Bellan C, Lazzi S, Claudio P, La Sala D, Cinti C, Tosi P, Giordano A, Leoncini L. Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms. Oncogene. 2003 Sep 18; 22(40):6214-9.
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Smith SM, Pentlicky S, Klase Z, Singh M, Neuveut C, Lu CY, Reitz MS, Yarchoan R, Marx PA, Jeang KT. An in vivo replication-important function in the second coding exon of Tat is constrained against mutation despite cytotoxic T lymphocyte selection. J Biol Chem. 2003 Nov 07; 278(45):44816-25.
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Zhang T, Tsang TC, Harris DT. Comparison of cis and trans tat gene expression in HIV LTR-based amplifier vectors. Biotechniques. 2002 Nov; 33(5):1146-51.