Zinc Finger Protein GLI1

"Zinc Finger Protein GLI1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcriptional activator and oncogene protein that contains two CYS2-HIS2 ZINC FINGERS. Two isoforms are expressed; both regulate the expression of specific genes during development of craniofacial features, digits, the CENTRAL NERVOUS SYSTEM; and the GASTROINTESTINAL TRACT. They also regulate SONIC HEDGEHOG PROTEIN signaling and cell proliferation.

Descriptor ID	D000071676
MeSH Number(s)	D12.776.260.755.850 D12.776.624.664.700.989 D12.776.930.900.700
Concept/Terms	Zinc Finger Protein GLI1 Zinc Finger Protein GLI1 Oncogene GLI Protein GLI Protein, Oncogene Glioma-Associated Oncogene Protein Glioma Associated Oncogene Protein Oncogene Protein, Glioma-Associated Gli Protein Gli1 Protein

Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein GLI1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Trans-Activators [D12.776.260.755]
Zinc Finger Protein GLI1 [D12.776.260.755.850]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Zinc Finger Protein GLI1 [D12.776.624.664.700.989]
Transcription Factors [D12.776.930]
Trans-Activators [D12.776.930.900]
Zinc Finger Protein GLI1 [D12.776.930.900.700]

Below are MeSH descriptors whose meaning is related to "Zinc Finger Protein GLI1".

Below are MeSH descriptors whose meaning is more specific than "Zinc Finger Protein GLI1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Zinc Finger Protein GLI1" by people in this website by year, and whether "Zinc Finger Protein GLI1" was a major or minor topic of these publications.

Bar chart showing 22 publications over 12 distinct years, with a maximum of 4 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2006	0	3	3
2007	0	2	2
2010	0	2	2
2011	0	2	2
2012	0	4	4
2014	0	1	1
2015	0	2	2
2018	0	1	1
2019	0	1	1
2020	2	0	2

Below are the most recent publications written about "Zinc Finger Protein GLI1" by people in Profiles.

Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME. GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression. Biochem J. 2020 09 18; 477(17):3131-3145.

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de Reyni?s A, Javelaud D, Elarouci N, Marsaud V, Gilbert C, Mauviel A. Large-scale pan-cancer analysis reveals broad prognostic association between TGF-? ligands, not Hedgehog, and GLI1/2 expression in tumors. Sci Rep. 2020 09 02; 10(1):14491.

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Banerjee S, Corless CL, Miettinen MM, Noh S, Ustoy R, Davis JL, Tang CM, Yebra M, Burgoyne AM, Sicklick JK. Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma. J Transl Med. 2019 07 30; 17(1):246.

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Brennan-Crispi DM, Overmiller AM, Tamayo-Orrego L, Marous MR, Sahu J, McGuinn KP, Cooper F, Georgiou IC, Frankfurter M, Salas-Alanis JC, Charron F, Millar SE, Mahoney MG, Riobo-Del Galdo NA. Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression. J Invest Dermatol. 2019 02; 139(2):300-307.

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Lee SJ, Litan A, Li Z, Graves B, Lindsey S, Barwe SP, Langhans SA. Na,K-ATPase ?1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Mol Cancer. 2015 Aug 19; 14:159.

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Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD. Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. J Clin Invest. 2015 Aug 03; 125(8):2935-51.

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Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol. 2014 Jul 01; 307(1):H66-72.

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Robbins DJ, Fei DL, Riobo NA. The Hedgehog signal transduction network. Sci Signal. 2012 Oct 16; 5(246):re6.

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Sims-Mourtada J, Yang D, Tworowska I, Larson R, Smith D, Tsao N, Opdenaker L, Mourtada F, Woodward W. Detection of canonical hedgehog signaling in breast cancer by 131-iodine-labeled derivatives of the sonic hedgehog protein. J Biomed Biotechnol. 2012; 2012:639562.

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Javelaud D, Pierrat MJ, Mauviel A. Crosstalk between TGF-? and hedgehog signaling in cancer. FEBS Lett. 2012 Jul 04; 586(14):2016-25.

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