Polymerase Chain Reaction

"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Descriptor ID	D016133
MeSH Number(s)	E05.393.620.500
Concept/Terms	Polymerase Chain Reaction Polymerase Chain Reaction Polymerase Chain Reactions Reaction, Polymerase Chain Reactions, Polymerase Chain PCR Inverse PCR Inverse PCR PCR, Inverse Inverse Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested PCR PCR, Nested Anchored PCR Anchored PCR PCR, Anchored Anchored Polymerase Chain Reaction

Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Nucleic Acid Amplification Techniques [E05.393.620]
Polymerase Chain Reaction [E05.393.620.500]

Below are MeSH descriptors whose meaning is related to "Polymerase Chain Reaction".

Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.

Bar chart showing 378 publications over 30 distinct years, with a maximum of 35 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	2	8	10
1994	1	9	10
1995	0	7	7
1996	0	8	8
1997	3	9	12
1998	1	3	4
1999	1	6	7
2000	0	3	3
2001	0	5	5
2002	0	16	16
2003	4	26	30
2004	4	31	35
2005	6	25	31
2006	0	20	20
2007	2	22	24
2008	2	23	25
2009	0	12	12
2010	1	22	23
2011	0	20	20
2012	1	12	13
2013	2	7	9
2014	1	8	9
2015	2	8	10
2016	0	8	8
2017	3	4	7
2018	0	5	5
2019	2	4	6
2020	1	3	4
2021	0	4	4
2022	0	1	1

Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.

Hamilton TW, Ingelsrud LH, Gutman M, Shearman AD, Gromov K, Alvand A, Troelsen A, Parvizi J, Price AJ. Preoperative Severe Acute Respiratory Syndrome Coronavirus 2?Polymerase Chain Reaction Test at Between 48 and 72?Hours Preoperatively is Safe for Patients Undergoing Primary and Revision Hip and Knee Arthroplasty: A Multicentre International Study. J Arthroplasty. 2022 07; 37(7):1253-1259.

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Lin SY, Su YP, Trauger ER, Song BP, Thompson EGC, Hoffman MC, Chang TT, Lin YJ, Kao YL, Cui Y, Hann HW, Park G, Shieh FS, Song W, Su YH. Detection of Hepatitis B Virus-Host Junction Sequences in Urine of Infected Patients. Hepatol Commun. 2021 10; 5(10):1649-1659.

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Onder AM, Cuff CF, Liang X, Billings AA, Onder S, Yu JJ, King JA. Detecting the prevalence of bacterial colonization on tunneled cuffed hemodialysis catheters using quantitative PCR targeting 16S rRNA and scanning electron microscopy. J Vasc Access. 2022 Sep; 23(5):743-753.

View in: PubMed
Stabley DL, Holbrook J, Scavina M, Crawford TO, Swoboda KJ, Robbins KM, Butchbach MER. Detection of SMN1 to SMN2 gene conversion events and partial SMN1 gene deletions using array digital PCR. Neurogenetics. 2021 03; 22(1):53-64.

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Poyatos-Jim?nez F, Morales F, Morales-Carrera R, Boffo S, Giordano A, Romero-Noguera J. Fungal and Bacterial Biodeterioration of Outdoor Canvas Paintings: The Case of the Cloisters of Quito, Ecuador. Crit Rev Eukaryot Gene Expr. 2021; 31(3):45-63.

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Sheppard CA, Bolen NL, Meny G, Kalvelage M, Ochoa-Garay G. Concordance of two polymerase chain reaction-based blood group genotyping platforms for patients with sickle cell disease. Immunohematology. 2020 Dec; 36(4):123-128.

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Vlachoyiannopoulos P, Alexopoulos H, Apostolidi I, Bitzogli K, Barba C, Athanasopoulou E, Dalakas M, Tzioufas A. Anti-SARS-CoV-2 antibody detection in healthcare workers of two tertiary hospitals in Athens, Greece. Clin Immunol. 2020 12; 221:108619.

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Righi A, Sbaraglia M, Gambarotti M, Gibertoni D, Rovira MP, Benini S, Errani C, Brenca M, Maestro R, Dei Tos AP. Primary Vascular Tumors of Bone: A Monoinstitutional Morphologic and Molecular Analysis of 427 Cases With Emphasis on Epithelioid Variants. Am J Surg Pathol. 2020 09; 44(9):1192-1203.

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Lee CS, Hong B, Kasi SK, Aderman C, Talcott KE, Adam MK, Yue B, Akileswaran L, Nakamichi K, Wu Y, Rezaei KA, Olmos de Koo LC, Chee YE, Lee AY, Garg SJ, Van Gelder RN. Prognostic Utility of Whole-Genome Sequencing and Polymerase Chain Reaction Tests of Ocular Fluids in Postprocedural Endophthalmitis. Am J Ophthalmol. 2020 09; 217:325-334.

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Pearson MD, Nguyen L, Zhao Y, McKenna WL, Morin TJ, Dunbar WB. Fast and accurate quantification of insertion-site specific transgene levels from raw seed samples using solid-state nanopore technology. PLoS One. 2019; 14(12):e0226719.

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