Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
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MeSH Number(s) |
E05.393.620.500
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Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
|
Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 8 | 8 |
1996 | 0 | 9 | 9 |
1997 | 2 | 8 | 10 |
1998 | 0 | 5 | 5 |
1999 | 1 | 8 | 9 |
2000 | 0 | 3 | 3 |
2001 | 0 | 5 | 5 |
2002 | 0 | 20 | 20 |
2003 | 4 | 30 | 34 |
2004 | 4 | 31 | 35 |
2005 | 6 | 25 | 31 |
2006 | 0 | 20 | 20 |
2007 | 2 | 23 | 25 |
2008 | 2 | 25 | 27 |
2009 | 0 | 12 | 12 |
2010 | 1 | 22 | 23 |
2011 | 0 | 20 | 20 |
2012 | 1 | 12 | 13 |
2013 | 2 | 8 | 10 |
2014 | 1 | 8 | 9 |
2015 | 2 | 9 | 11 |
2016 | 0 | 10 | 10 |
2017 | 3 | 5 | 8 |
2018 | 0 | 3 | 3 |
2019 | 2 | 5 | 7 |
2020 | 1 | 3 | 4 |
2021 | 1 | 4 | 5 |
2022 | 0 | 1 | 1 |
2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Mandel J, Gleason L, Joffe D, Bhatti S, Nikbakht N. Immunosequencing applications in cutaneous T-cell lymphoma. Front Immunol. 2023; 14:1300061.
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Fernandez-Tejero N, Sanchez AN, Ghemrawi M, Bilodeau C, Etim S, Duncan G, Cochran M, McCord B. A study of the potential application of digital PCR in the detection of fecal contamination of strawberries using Bacteroides markers. J Microbiol Methods. 2023 09; 212:106811.
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Hamilton TW, Ingelsrud LH, Gutman M, Shearman AD, Gromov K, Alvand A, Troelsen A, Parvizi J, Price AJ. Preoperative Severe Acute Respiratory Syndrome Coronavirus 2?Polymerase Chain Reaction Test at Between 48 and 72?Hours Preoperatively is Safe for Patients Undergoing Primary and Revision Hip and Knee Arthroplasty: A Multicentre International Study. J Arthroplasty. 2022 07; 37(7):1253-1259.
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Lin SY, Su YP, Trauger ER, Song BP, Thompson EGC, Hoffman MC, Chang TT, Lin YJ, Kao YL, Cui Y, Hann HW, Park G, Shieh FS, Song W, Su YH. Detection of Hepatitis B Virus-Host Junction Sequences in Urine of Infected Patients. Hepatol Commun. 2021 10; 5(10):1649-1659.
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Boelens D, Fogliatto Mariot R, Ghemrawi M, Kloosterman AD, McCord BR. The development of miniSTRs as a method for high-speed direct PCR. Electrophoresis. 2021 07; 42(12-13):1352-1361.
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Onder AM, Cuff CF, Liang X, Billings AA, Onder S, Yu JJ, King JA. Detecting the prevalence of bacterial colonization on tunneled cuffed hemodialysis catheters using quantitative PCR targeting 16S rRNA and scanning electron microscopy. J Vasc Access. 2022 Sep; 23(5):743-753.
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Stabley DL, Holbrook J, Scavina M, Crawford TO, Swoboda KJ, Robbins KM, Butchbach MER. Detection of SMN1 to SMN2 gene conversion events and partial SMN1 gene deletions using array digital PCR. Neurogenetics. 2021 03; 22(1):53-64.
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Poyatos-Jim?nez F, Morales F, Morales-Carrera R, Boffo S, Giordano A, Romero-Noguera J. Fungal and Bacterial Biodeterioration of Outdoor Canvas Paintings: The Case of the Cloisters of Quito, Ecuador. Crit Rev Eukaryot Gene Expr. 2021; 31(3):45-63.
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Sheppard CA, Bolen NL, Meny G, Kalvelage M, Ochoa-Garay G. Concordance of two polymerase chain reaction-based blood group genotyping platforms for patients with sickle cell disease. Immunohematology. 2020 Dec; 36(4):123-128.
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Vlachoyiannopoulos P, Alexopoulos H, Apostolidi I, Bitzogli K, Barba C, Athanasopoulou E, Dalakas M, Tzioufas A. Anti-SARS-CoV-2 antibody detection in healthcare workers of two tertiary hospitals in Athens, Greece. Clin Immunol. 2020 12; 221:108619.