Polymerase Chain Reaction

"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Descriptor ID	D016133
MeSH Number(s)	E05.393.620.500
Concept/Terms	Polymerase Chain Reaction Polymerase Chain Reaction Polymerase Chain Reactions Reaction, Polymerase Chain Reactions, Polymerase Chain PCR Inverse PCR Inverse PCR PCR, Inverse Inverse Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested PCR PCR, Nested Anchored PCR Anchored PCR PCR, Anchored Anchored Polymerase Chain Reaction

Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Nucleic Acid Amplification Techniques [E05.393.620]
Polymerase Chain Reaction [E05.393.620.500]

Below are MeSH descriptors whose meaning is related to "Polymerase Chain Reaction".

Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.

Bar chart showing 756 publications over 30 distinct years, with a maximum of 69 publications in 1997

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	54	55
1996	3	47	50
1997	7	62	69
1998	4	41	45
1999	3	26	29
2000	4	34	38
2001	2	27	29
2002	0	26	26
2003	6	34	40
2004	4	37	41
2005	6	31	37
2006	2	27	29
2007	2	30	32
2008	2	32	34
2009	0	18	18
2010	1	25	26
2011	0	22	22
2012	3	18	21
2013	2	17	19
2014	2	15	17
2015	3	14	17
2016	2	15	17
2017	3	8	11
2018	1	6	7
2019	2	8	10
2020	1	4	5
2021	1	6	7
2022	0	1	1
2023	0	3	3
2024	1	0	1

Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.

Chau VQ, Hinkle JW, Wu CY, Pakravan P, Volante V, Sengillo JD, Staropoli PC, Miller D, Yannuzzi NA, Albini TA. OUTCOMES OF INFECTIOUS PANUVEITIS ASSOCIATED WITH SIMULTANEOUS MULTI-POSITIVE OCULAR FLUID POLYMERASE CHAIN REACTION. Retina. 2024 05 01; 44(5):909-915.

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Mandel J, Gleason L, Joffe D, Bhatti S, Nikbakht N. Immunosequencing applications in cutaneous T-cell lymphoma. Front Immunol. 2023; 14:1300061.

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Fernandez-Tejero N, Sanchez AN, Ghemrawi M, Bilodeau C, Etim S, Duncan G, Cochran M, McCord B. A study of the potential application of digital PCR in the detection of fecal contamination of strawberries using Bacteroides markers. J Microbiol Methods. 2023 09; 212:106811.

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Mudhar HS, Milman T, Stevenson S, Watson M, Kim J, Magan T, Salvi SM, Harley U, Lally SE, Shields CL. PRAME expression by immunohistochemistry and reverse transcription quantitative PCR in conjunctival melanocytic lesions-a comprehensive clinicopathologic study of 202 cases and correlation of cytogenetics with PRAME expression in challenging conjunctival melanocytic lesions. Hum Pathol. 2023 04; 134:1-18.

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Hamilton TW, Ingelsrud LH, Gutman M, Shearman AD, Gromov K, Alvand A, Troelsen A, Parvizi J, Price AJ. Preoperative Severe Acute Respiratory Syndrome Coronavirus 2?Polymerase Chain Reaction Test at Between 48 and 72?Hours Preoperatively is Safe for Patients Undergoing Primary and Revision Hip and Knee Arthroplasty: A Multicentre International Study. J Arthroplasty. 2022 07; 37(7):1253-1259.

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Pilishvili T, Gierke R, Fleming-Dutra KE, Farrar JL, Mohr NM, Talan DA, Krishnadasan A, Harland KK, Smithline HA, Hou PC, Lee LC, Lim SC, Moran GJ, Krebs E, Steele MT, Beiser DG, Faine B, Haran JP, Nandi U, Schrading WA, Chinnock B, Henning DJ, Lovecchio F, Lee J, Barter D, Brackney M, Fridkin SK, Marceaux-Galli K, Lim S, Phipps EC, Dumyati G, Pierce R, Markus TM, Anderson DJ, Debes AK, Lin MY, Mayer J, Kwon JH, Safdar N, Fischer M, Singleton R, Chea N, Magill SS, Verani JR, Schrag SJ. Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel. N Engl J Med. 2021 12 16; 385(25):e90.

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Lin SY, Su YP, Trauger ER, Song BP, Thompson EGC, Hoffman MC, Chang TT, Lin YJ, Kao YL, Cui Y, Hann HW, Park G, Shieh FS, Song W, Su YH. Detection of Hepatitis B Virus-Host Junction Sequences in Urine of Infected Patients. Hepatol Commun. 2021 10; 5(10):1649-1659.

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Boelens D, Fogliatto Mariot R, Ghemrawi M, Kloosterman AD, McCord BR. The development of miniSTRs as a method for high-speed direct PCR. Electrophoresis. 2021 07; 42(12-13):1352-1361.

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Onder AM, Cuff CF, Liang X, Billings AA, Onder S, Yu JJ, King JA. Detecting the prevalence of bacterial colonization on tunneled cuffed hemodialysis catheters using quantitative PCR targeting 16S rRNA and scanning electron microscopy. J Vasc Access. 2022 Sep; 23(5):743-753.

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Tsuchida N, Kunishita Y, Uchiyama Y, Kirino Y, Enaka M, Yamaguchi Y, Taguri M, Yamanaka S, Takase-Minegishi K, Yoshimi R, Fujii S, Nakajima H, Matsumoto N. Pathogenic UBA1 variants associated with VEXAS syndrome in Japanese patients with relapsing polychondritis. Ann Rheum Dis. 2021 08; 80(8):1057-1061.

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