Leuprolide

"Leuprolide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.

Descriptor ID	D016729
MeSH Number(s)	D06.472.699.327.740.320.400 D12.644.400.400.740.320.400 D12.644.456.460.480 D12.644.548.365.740.320.400 D12.776.631.650.405.740.320.400
Concept/Terms	Leuprolide Leuprolide Leuprorelin Enantone Enantone Leuprolide Acetate Leuprolide Acetate Acetate, Leuprolide Leuprolide Monoacetate Leuprolide Monoacetate Monoacetate, Leuprolide Leuprolide, (L-Leu)-Isomer Leuprolide, (L-Leu)-Isomer Lupron Lupron TAP-144 TAP-144 TAP 144 TAP144 A-43818 A-43818 A 43818 A43818 Leuprolide, (DL-Leu)-Isomer Leuprolide, (DL-Leu)-Isomer

Below are MeSH descriptors whose meaning is more general than "Leuprolide".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Hypothalamic Hormones [D06.472.699.327]
Pituitary Hormone-Releasing Hormones [D06.472.699.327.740]
Gonadotropin-Releasing Hormone [D06.472.699.327.740.320]
Leuprolide [D06.472.699.327.740.320.400]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Neuropeptides [D12.644.400]
Hypothalamic Hormones [D12.644.400.400]
Pituitary Hormone-Releasing Hormones [D12.644.400.400.740]
Gonadotropin-Releasing Hormone [D12.644.400.400.740.320]
Leuprolide [D12.644.400.400.740.320.400]
Oligopeptides [D12.644.456]
Gonadotropin-Releasing Hormone [D12.644.456.460]
Leuprolide [D12.644.456.460.480]
Peptide Hormones [D12.644.548]
Hypothalamic Hormones [D12.644.548.365]
Pituitary Hormone-Releasing Hormones [D12.644.548.365.740]
Gonadotropin-Releasing Hormone [D12.644.548.365.740.320]
Leuprolide [D12.644.548.365.740.320.400]
Proteins [D12.776]
Nerve Tissue Proteins [D12.776.631]
Neuropeptides [D12.776.631.650]
Hypothalamic Hormones [D12.776.631.650.405]
Pituitary Hormone-Releasing Hormones [D12.776.631.650.405.740]
Gonadotropin-Releasing Hormone [D12.776.631.650.405.740.320]
Leuprolide [D12.776.631.650.405.740.320.400]

Below are MeSH descriptors whose meaning is related to "Leuprolide".

Below are MeSH descriptors whose meaning is more specific than "Leuprolide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Leuprolide" by people in this website by year, and whether "Leuprolide" was a major or minor topic of these publications.

Bar chart showing 24 publications over 16 distinct years, with a maximum of 4 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2002	1	0	1
2004	1	0	1
2005	1	0	1
2006	2	0	2
2007	1	1	2
2009	3	1	4
2012	1	0	1
2013	0	1	1
2014	1	1	2
2016	1	1	2
2018	1	0	1
2019	1	1	2
2020	1	0	1
2024	1	0	1

Below are the most recent publications written about "Leuprolide" by people in Profiles.

Klein KO, Vargas Trujillo M, Dragnic S, Van Komen S, Li M, Lee PA. Timing of onset of menses after GnRH agonist treatment for central precocious puberty. J Pediatr Endocrinol Metab. 2024 May 27; 37(5):451-461.

View in: PubMed
Klein KO, Freire A, Gryngarten MG, Kletter GB, Benson M, Miller BS, Dajani TS, Eugster EA, Mauras N. Phase 3 Trial of a Small-volume Subcutaneous 6-Month Duration Leuprolide Acetate Treatment for Central Precocious Puberty. J Clin Endocrinol Metab. 2020 10 01; 105(10).

View in: PubMed
Klein KO, Soliman AM, Bonafede M, Nelson JK, Grubb E. Treatment patterns, health resource utilization and costs among central precocious puberty patients treated with leuprolide or histrelin: an examination of the commercial and Medicaid populations. J Med Econ. 2020 Apr; 23(4):407-414.

View in: PubMed
Klein K, Soliman AM, Bonafede M, Nelson JK, Grubb E. Health Care Utilization and Economic Burden in Patients with Central Precocious Puberty: An Assessment of the Commercially Insured and Medicaid Populations. J Manag Care Spec Pharm. 2019 Jul; 25(7):836-846.

View in: PubMed
Klein KO, Dragnic S, Soliman AM, Bacher P. Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate. J Pediatr Endocrinol Metab. 2018 Jun 27; 31(6):655-663.

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Montgomery B, Tretiakova MS, Joshua AM, Gleave ME, Fleshner N, Bubley GJ, Mostaghel EA, Chi KN, Lin DW, Sanda M, Novotny W, Wu K, Kantoff PW, Marck BT, Plymate S, Balk SP, Nelson PS, Matsumoto AM, Lis RT, Kibel A, Haas GP, Krivoshik A, Hannah A, Taplin ME. Neoadjuvant Enzalutamide Prior to Prostatectomy. Clin Cancer Res. 2017 May 01; 23(9):2169-2176.

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Chang FE, Beall SA, Cox JM, Richter KS, DeCherney AH, Levy MJ. Assessing the adequacy of gonadotropin-releasing hormone agonist leuprolide to trigger oocyte maturation and management of inadequate response. Fertil Steril. 2016 Oct; 106(5):1093-1100.e3.

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Klein KO. Is there a role for estrogen activity assays? Recombinant cell bioassay for estrogen: Development and applications. Steroids. 2015 Jul; 99(Pt A):108-12.

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Lee PA, Klein K, Mauras N, Lev-Vaisler T, Bacher P. 36-month treatment experience of two doses of leuprolide acetate 3-month depot for children with central precocious puberty. J Clin Endocrinol Metab. 2014 Sep; 99(9):3153-9.

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Lewis EI, Chason RJ, DeCherney AH, Armstrong A, Elkas J, Venkatesan AM. Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review. Fertil Steril. 2013 Jun; 99(7):2017-24.

View in: PubMed

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