"Stiff-Person Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
Descriptor ID |
D016750
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MeSH Number(s) |
C10.114.812 C10.228.854.790 C10.668.900 C20.111.258.850
|
Concept/Terms |
Stiff-Person Syndrome- Stiff-Person Syndrome
- Stiff Person Syndrome
- Syndrome, Stiff-Person
- Stiff-Man Syndrome
- Stiff Man Syndrome
- Syndrome, Stiff-Man
- Stiffman Syndrome
- Syndrome, Stiffman
- Stiff-Baby Syndrome
- Stiff-Baby Syndromes
- Syndrome, Stiff-Baby
- Syndromes, Stiff-Baby
- Congenital Stiff-Man Syndrome
- Congenital Stiff Man Syndrome
- Congenital Stiff-Man Syndromes
- Stiff-Man Syndrome, Congenital
- Stiff-Man Syndromes, Congenital
- Syndrome, Congenital Stiff-Man
- Syndromes, Congenital Stiff-Man
- Congenital Stiff-Person Syndrome
- Congenital Stiff-Person Syndromes
- Stiff-Person Syndrome, Congenital
- Stiff-Person Syndromes, Congenital
- Syndrome, Congenital Stiff-Person
- Syndromes, Congenital Stiff-Person
- Startle Syndrome
- Startle Syndromes
- Syndrome, Startle
- Syndromes, Startle
- Moersch-Woltmann Syndrome
- Moersch Woltmann Syndrome
- Syndrome, Moersch-Woltmann
- Stiff-Trunk Syndrome
- Stiff Trunk Syndrome
- Stiff-Trunk Syndromes
- Syndrome, Stiff-Trunk
- Syndromes, Stiff-Trunk
Familial Hyperekplexia- Familial Hyperekplexia
- Familial Hyperekplexias
- Hyperekplexia, Familial
- Hyperekplexias, Familial
Hereditary Hyperekplexia- Hereditary Hyperekplexia
- Hereditary Hyperekplexias
- Hyperekplexia, Hereditary
- Hyperekplexias, Hereditary
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Below are MeSH descriptors whose meaning is more general than "Stiff-Person Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Stiff-Person Syndrome".
This graph shows the total number of publications written about "Stiff-Person Syndrome" by people in this website by year, and whether "Stiff-Person Syndrome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2004 | 1 | 0 | 1 |
2005 | 5 | 0 | 5 |
2006 | 2 | 0 | 2 |
2007 | 1 | 0 | 1 |
2008 | 1 | 1 | 2 |
2010 | 1 | 0 | 1 |
2012 | 2 | 0 | 2 |
2019 | 1 | 0 | 1 |
2022 | 1 | 0 | 1 |
2023 | 2 | 0 | 2 |
2024 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Stiff-Person Syndrome" by people in Profiles.
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Dalakas MC. Stiff Person Syndrome and GAD Antibody-Spectrum Disorders. Continuum (Minneap Minn). 2024 Aug 01; 30(4):1110-1135.
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Dalakas MC. Severe Stiff-Person Syndrome After COVID. Neurol Neuroimmunol Neuroinflamm. 2024 Mar; 11(2):e200192.
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Dalakas MC. Therapies in Stiff-Person Syndrome: Advances and Future Prospects Based on Disease Pathophysiology. Neurol Neuroimmunol Neuroinflamm. 2023 05; 10(3).
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Yi J, Dalakas MC. Long-term Effectiveness of IVIg Maintenance Therapy in 36 Patients With GAD Antibody-Positive Stiff-Person Syndrome. Neurol Neuroimmunol Neuroinflamm. 2022 Sep; 9(5).
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Rakocevic G, Alexopoulos H, Dalakas MC. Quantitative clinical and autoimmune assessments in stiff person syndrome: evidence for a progressive disorder. BMC Neurol. 2019 Jan 03; 19(1):1.
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Rakocevic G, Floeter MK. Autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes. Muscle Nerve. 2012 May; 45(5):623-34.
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Schreiber AL, Vasudevan JM, Fetouh SK, Ankam NS, Hussain A, Rakocevic G. Atypical clinically diagnosed stiff-person syndrome response to dantrolene--a refractory case. Muscle Nerve. 2012 Mar; 45(3):454-5.
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Alexopoulos H, Dalakas MC. A critical update on the immunopathogenesis of Stiff Person Syndrome. Eur J Clin Invest. 2010 Nov; 40(11):1018-25.
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Dalakas M. IVIg in other autoimmune neurological disorders: current status and future prospects. J Neurol. 2008 Jul; 255 Suppl 3:12-6.
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Dalakas MC. Advances in the pathogenesis and treatment of patients with stiff person syndrome. Curr Neurol Neurosci Rep. 2008 Jan; 8(1):48-55.