Motor Neuron Disease

"Motor Neuron Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)

Descriptor ID	D016472
MeSH Number(s)	C10.574.562 C10.668.467
Concept/Terms	Motor Neuron Disease Motor Neuron Disease Motor Neuron Diseases Neuron Disease, Motor Neuron Diseases, Motor Motor System Disease Motor System Diseases Familial Motor Neuron Disease Familial Motor Neuron Disease Motor Neuron Disease, Familial Lateral Sclerosis Lateral Sclerosis Lateral Scleroses Scleroses, Lateral Sclerosis, Lateral Primary Lateral Sclerosis Lateral Scleroses, Primary Lateral Sclerosis, Primary Primary Lateral Scleroses Scleroses, Primary Lateral Sclerosis, Primary Lateral Motor Neuron Disease, Upper Motor Neuron Disease, Upper Upper Motor Neuron Disease Motor Neuron Disease, Secondary Motor Neuron Disease, Secondary Secondary Motor Neuron Disease Anterior Horn Cell Disease Anterior Horn Cell Disease Motor Neuron Disease, Lower Motor Neuron Disease, Lower Lower Motor Neuron Disease

Below are MeSH descriptors whose meaning is more general than "Motor Neuron Disease".

Below are MeSH descriptors whose meaning is more specific than "Motor Neuron Disease".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Motor Neuron Disease" by people in this website by year, and whether "Motor Neuron Disease" was a major or minor topic of these publications.

Bar chart showing 23 publications over 16 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
1999	1	0	1
2002	2	0	2
2003	0	1	1
2004	1	1	2
2005	1	0	1
2006	1	1	2
2007	1	0	1
2008	1	1	2
2009	2	1	3
2011	1	0	1
2013	1	1	2
2017	1	0	1
2019	0	1	1
2020	1	0	1
2022	1	0	1

Below are the most recent publications written about "Motor Neuron Disease" by people in Profiles.

Alexander GM, Heiman-Patterson TD, Bearoff F, Sher RB, Hennessy L, Terek S, Caccavo N, Cox GA, Philip VM, Blankenhorn EA. Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease. PLoS One. 2022; 17(9):e0274615.

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Paganoni S, De Marchi F, Chan J, Thrower SK, Staff NP, Datta N, Kisanuki YY, Drory V, Fournier C, Pioro EP, Goutman SA, Atassi N, Jeon M, Caldwell S, Mcdonough T, Gentile C, Liu J, Turner M, Denny C, Felice K, Green M, Scarberry S, Abu-Saleh S, Nefussy B, Hastings D, Kim S, Swihart B, Arcila-Londono X, Newman DS, Silverman M, Genge A, Salmon K, Elman L, Mccluskey L, Almasy K, Gotkine M, Goslin K, Cummings A, Edwards EK, Rivner M, Bouchard K, Quarles B, Kwan J, Jaffa M, Baloh R, Allred P, Walk D, Maiser S, Manousakis G, Ferment V, Fernandes JAM, Thaisetthawatkul P, Heimes D, Phillips M, Sams L, Kahler M, Corcoran A, Larriviere DG, Chotto S, Juba G. The NEALS primary lateral sclerosis registry. Amyotroph Lateral Scler Frontotemporal Degener. 2020 11; 21(sup1):74-81.

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Olsson B, Portelius E, Cullen NC, Sandelius ?, Zetterberg H, Andreasson U, H?glund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, Toledo JB, McBride J, Hernandez-Con P, Lee VM, Trojanowski JQ, Blennow K. Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. JAMA Neurol. 2019 03 01; 76(3):318-325.

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Cristofani R, Crippa V, Rusmini P, Cicardi ME, Meroni M, Licata NV, Sala G, Giorgetti E, Grunseich C, Galbiati M, Piccolella M, Messi E, Ferrarese C, Carra S, Poletti A. Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases. Autophagy. 2017 Aug 03; 13(8):1280-1303.

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Namdari S, Baldwin K, Horneff JG, Keenan MA. Orthopedic evaluation and surgical treatment of the spastic shoulder. Orthop Clin North Am. 2013 Oct; 44(4):605-14.

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Anakwenze OA, Namdari S, Hsu JE, Benham J, Keenan MA. Myotendinous lengthening of the elbow flexor muscles to improve active motion in patients with elbow spasticity following brain injury. J Shoulder Elbow Surg. 2013 Mar; 22(3):318-22.

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Geser F, Stein B, Partain M, Elman LB, McCluskey LF, Xie SX, Van Deerlin VM, Kwong LK, Lee VM, Trojanowski JQ. Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy. Acta Neuropathol. 2011 Apr; 121(4):509-17.

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Hu WT, Seelaar H, Josephs KA, Knopman DS, Boeve BF, Sorenson EJ, McCluskey L, Elman L, Schelhaas HJ, Parisi JE, Kuesters B, Lee VM, Trojanowski JQ, Petersen RC, van Swieten JC, Grossman M. Survival profiles of patients with frontotemporal dementia and motor neuron disease. Arch Neurol. 2009 Nov; 66(11):1359-64.

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Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009 Jun 24; 29(25):8236-47.

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Geser F, Martinez-Lage M, Robinson J, Uryu K, Neumann M, Brandmeir NJ, Xie SX, Kwong LK, Elman L, McCluskey L, Clark CM, Malunda J, Miller BL, Zimmerman EA, Qian J, Van Deerlin V, Grossman M, Lee VM, Trojanowski JQ. Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Arch Neurol. 2009 Feb; 66(2):180-9.

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