beta-Thalassemia

"beta-Thalassemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

Descriptor ID	D017086
MeSH Number(s)	C15.378.071.141.150.875.150 C15.378.420.826.150 C16.320.070.875.150 C16.320.365.826.150
Concept/Terms	beta-Thalassemia beta-Thalassemia Microcytemia, beta Type Microcytemias, beta Type Type Microcytemia, beta Type Microcytemias, beta beta Type Microcytemia beta Type Microcytemias beta Thalassemia Thalassemia, beta Thalassemias, beta beta Thalassemias Thalassemia, beta Type Thalassemias, beta Type Type Thalassemia, beta Type Thalassemias, beta beta Type Thalassemia beta Type Thalassemias Thalassemia Intermedia Thalassemia Intermedia Intermedia, Thalassemia Intermedias, Thalassemia Thalassemia Intermedias Thalassemia Minor Thalassemia Minor Thalassemia Minor (beta-Thalassemia Minor) Minor, Thalassemia (beta-Thalassemia Minor) Minors, Thalassemia (beta-Thalassemia Minor) Thalassemia Minor (beta Thalassemia Minor) Thalassemia Minors (beta-Thalassemia Minor) Hemoglobin F Disease Hemoglobin F Disease Disease, Hemoglobin F Thalassemia Major Thalassemia Major Anemia, Erythroblastic Anemias, Erythroblastic Erythroblastic Anemia Thalassemia Major (beta-Thalassemia Major) Major, Thalassemia (beta-Thalassemia Major) Majors, Thalassemia (beta-Thalassemia Major) Thalassemia Major (beta Thalassemia Major) Thalassemia Majors (beta-Thalassemia Major) Mediterranean Anemia Anemias, Mediterranean Mediterranean Anemias Anemia, Cooley's Anemia, Cooley Anemia, Cooleys Cooley's Anemia Anemia, Mediterranean

Below are MeSH descriptors whose meaning is more general than "beta-Thalassemia".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Anemia [C15.378.071]
Anemia, Hemolytic [C15.378.071.141]
Anemia, Hemolytic, Congenital [C15.378.071.141.150]
Thalassemia [C15.378.071.141.150.875]
beta-Thalassemia [C15.378.071.141.150.875.150]
Hemoglobinopathies [C15.378.420]
Thalassemia [C15.378.420.826]
beta-Thalassemia [C15.378.420.826.150]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Anemia, Hemolytic, Congenital [C16.320.070]
Thalassemia [C16.320.070.875]
beta-Thalassemia [C16.320.070.875.150]
Hemoglobinopathies [C16.320.365]
Thalassemia [C16.320.365.826]
beta-Thalassemia [C16.320.365.826.150]

Below are MeSH descriptors whose meaning is related to "beta-Thalassemia".

Below are MeSH descriptors whose meaning is more specific than "beta-Thalassemia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta-Thalassemia" by people in this website by year, and whether "beta-Thalassemia" was a major or minor topic of these publications.

Bar chart showing 29 publications over 20 distinct years, with a maximum of 3 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1997	2	0	2
1998	1	0	1
1999	0	1	1
2000	1	1	2
2002	2	0	2
2004	1	0	1
2005	1	0	1
2011	0	1	1
2012	2	1	3
2015	2	0	2
2016	2	0	2
2017	2	0	2
2018	1	1	2
2019	1	0	1
2020	1	0	1
2021	0	1	1
2022	1	0	1
2023	1	0	1
2025	1	0	1

Below are the most recent publications written about "beta-Thalassemia" by people in Profiles.

Jafri L, Jameel Farooqui A, Moiz B, Sheikh A, Majid H, Nadeem S, Quddus R, Khan S, Khan QU, Habib Khan A. Factors associated with phosphate homeostasis in children with beta-thalassemia major: An analytical cross sectional study from Pakistan. PLoS One. 2025; 20(2):e0316566.

View in: PubMed
Parrow NL, Fleming RE. Transferrin receptor 1: keeper of HFE. Blood. 2023 01 26; 141(4):332-333.

View in: PubMed
Jafri L, Farooqui AJ, Khan AH. An Urgent Need for Local Guidelines to Address Phosphate Homeostasis in Children with Transfusion-dependent ?-thalassemia Major. J Coll Physicians Surg Pak. 2022 Sep; 32(9):1235.

View in: PubMed
Castro-Mollo M, Gera S, Ruiz-Martinez M, Feola M, Gumerova A, Planoutene M, Clementelli C, Sangkhae V, Casu C, Kim SM, Ostland V, Han H, Nemeth E, Fleming R, Rivella S, Lizneva D, Yuen T, Zaidi M, Ginzburg Y. The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry. Elife. 2021 05 18; 10.

View in: PubMed
Falkner B. Blood pressure unknowns of sickle cell disease in children. J Clin Hypertens (Greenwich). 2020 08; 22(8):1450-1451.

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Casu C, Chessa R, Liu A, Gupta R, Drakesmith H, Fleming R, Ginzburg YZ, MacDonald B, Rivella S. Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult ?-thalassemia major. Haematologica. 2020 07; 105(7):1835-1844.

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Ginzburg YZ, Fleming RE. Tfr2 suppression benefits ?-thalassemic erythropoiesis. Blood. 2018 11 22; 132(21):2215-2216.

View in: PubMed
Niihara Y, Miller ST, Kanter J, Lanzkron S, Smith WR, Hsu LL, Gordeuk VR, Viswanathan K, Sarnaik S, Osunkwo I, Guillaume E, Sadanandan S, Sieger L, Lasky JL, Panosyan EH, Blake OA, New TN, Bellevue R, Tran LT, Razon RL, Stark CW, Neumayr LD, Vichinsky EP. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med. 2018 Jul 19; 379(3):226-235.

View in: PubMed
Sood R, Jiramongkolchai K, Streiff M, Gonzalez C, Shanbhag S, Lanzkron S, Arevalo JF, Naik R. Look into my eyes: An unusual first presentation of sickle cell disease. Am J Hematol. 2017 Sep; 92(9):968-971.

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Li H, Choesang T, Bao W, Chen H, Feola M, Garcia-Santos D, Li J, Sun S, Follenzi A, Pham P, Liu J, Zhang J, Ponka P, An X, Mohandas N, Fleming RE, Rivella S, Li G, Ginzburg YZ. Decreasing TfR1 expression reverses anemia and hepcidin suppression in ?-thalassemic mice. Blood. 2017 03 16; 129(11):1514-1526.

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