Receptor-CD3 Complex, Antigen, T-Cell
"Receptor-CD3 Complex, Antigen, T-Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Molecule composed of the non-covalent association of the T-cell antigen receptor (RECEPTORS, ANTIGEN, T-CELL) with the CD3 complex (CD3 COMPLEX). This association is required for the surface expression and function of both components. The molecule consists of up to seven chains: either the alpha/beta or gamma/delta chains of the T-cell receptor, and four or five chains in the CD3 complex.
| Descriptor ID |
D017260
|
| MeSH Number(s) |
D12.776.543.750.705.816.824.800 D23.050.301.264.894.095.800 D23.101.100.894.095.800
|
| Concept/Terms |
Receptor-CD3 Complex, Antigen, T-Cell- Receptor-CD3 Complex, Antigen, T-Cell
- TCR-CD3 Complex
- Complex, TCR-CD3
- TCR CD3 Complex
- T-Cell Antigen Receptor-CD3 Complex
- T Cell Antigen Receptor CD3 Complex
|
Below are MeSH descriptors whose meaning is more general than "Receptor-CD3 Complex, Antigen, T-Cell".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Antigen [D12.776.543.750.705.816]
- Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]
- Receptor-CD3 Complex, Antigen, T-Cell [D12.776.543.750.705.816.824.800]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- CD3 Complex [D23.050.301.264.894.095]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.050.301.264.894.095.800]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- CD3 Complex [D23.101.100.894.095]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.101.100.894.095.800]
Below are MeSH descriptors whose meaning is more specific than "Receptor-CD3 Complex, Antigen, T-Cell".
This graph shows the total number of publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in this website by year, and whether "Receptor-CD3 Complex, Antigen, T-Cell" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in Profiles.
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Wang H, Holst J, Woo SR, Guy C, Bettini M, Wang Y, Shafer A, Naramura M, Mingueneau M, Dragone LL, Hayes SM, Malissen B, Band H, Vignali DA. Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. EMBO J. 2010 Apr 07; 29(7):1285-98.
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La Gruta NL, Liu H, Dilioglou S, Rhodes M, Wiest DL, Vignali DA. Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation. J Immunol. 2004 Mar 15; 172(6):3662-9.
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Liu H, Rhodes M, Wiest DL, Vignali DA. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity. 2000 Nov; 13(5):665-75.
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Michie AM, Trop S, Wiest DL, Z??iga-Pfl?cker JC. Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo. J Exp Med. 1999 Dec 06; 190(11):1647-56.
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Carleton M, Ruetsch NR, Berger MA, Rhodes M, Kaptik S, Wiest DL. Signals transduced by CD3epsilon, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro. J Immunol. 1999 Sep 01; 163(5):2576-85.
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Dave VP, Keefe R, Berger MA, Drbal K, Punt JA, Wiest DL, Alarcon B, Kappes DJ. Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement. Int Immunol. 1998 Oct; 10(10):1481-90.
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Berger MA, Dav? V, Rhodes MR, Bosma GC, Bosma MJ, Kappes DJ, Wiest DL. Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required. J Exp Med. 1997 Nov 03; 186(9):1461-7.
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Wiest DL, Burgess WH, McKean D, Kearse KP, Singer A. The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes. EMBO J. 1995 Jul 17; 14(14):3425-33.
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Wiest DL, Kearse KP, Shores EW, Singer A. Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes. J Exp Med. 1994 Oct 01; 180(4):1375-82.