CD3 Complex

"CD3 Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

Descriptor ID	D017252
MeSH Number(s)	D23.050.301.264.894.095 D23.101.100.894.095
Concept/Terms	CD3 Complex CD3 Complex T3 Antigens Antigens, T3 T3 Complex CD3 Antigens Antigens, CD3 T3 Antigen Antigen, T3 CD3 Antigen Antigen, CD3

Below are MeSH descriptors whose meaning is more general than "CD3 Complex".

Chemicals and Drugs [D]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Antigens, Differentiation [D23.050.301.264]
Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
CD3 Complex [D23.050.301.264.894.095]
Biomarkers [D23.101]
Antigens, Differentiation [D23.101.100]
Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
CD3 Complex [D23.101.100.894.095]

Below are MeSH descriptors whose meaning is related to "CD3 Complex".

Below are MeSH descriptors whose meaning is more specific than "CD3 Complex".

CD3 Complex
Receptor-CD3 Complex, Antigen, T-Cell

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CD3 Complex" by people in this website by year, and whether "CD3 Complex" was a major or minor topic of these publications.

Bar chart showing 36 publications over 17 distinct years, with a maximum of 5 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	2	2
1998	0	2	2
2000	1	3	4
2001	0	1	1
2002	1	1	2
2004	0	1	1
2005	0	2	2
2006	2	1	3
2007	0	5	5
2008	1	1	2
2009	0	2	2
2010	0	2	2
2013	1	1	2
2016	0	2	2
2019	1	0	1
2020	1	1	2

Below are the most recent publications written about "CD3 Complex" by people in Profiles.

Fernandez SV, MacFarlane AW, Jillab M, Arisi MF, Yearley J, Annamalai L, Gong Y, Cai KQ, Alpaugh RK, Cristofanilli M, Campbell KS. Immune phenotype of patients with stage IV metastatic inflammatory breast cancer. Breast Cancer Res. 2020 12 02; 22(1):134.

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Frerichs KA, Broekmans MEC, Marin Soto JA, van Kessel B, Heymans MW, Holthof LC, Verkleij CPM, Boominathan R, Vaidya B, Sendecki J, Axel A, Gaudet F, Pillarisetti K, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ. Preclinical Activity of JNJ-7957, a Novel BCMA?CD3 Bispecific Antibody for the Treatment of Multiple Myeloma, Is Potentiated by Daratumumab. Clin Cancer Res. 2020 05 01; 26(9):2203-2215.

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Yu S, Zhang J, Yan Y, Yao X, Fang L, Xiong H, Liu Y, Chu Q, Zhou P, Wu K. A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells. J Exp Clin Cancer Res. 2019 Aug 14; 38(1):355.

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Zeigler-Johnson C, Morales KH, Lal P, Feldman M. The Relationship between Obesity, Prostate Tumor Infiltrating Lymphocytes and Macrophages, and Biochemical Failure. PLoS One. 2016; 11(8):e0159109.

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Nunnari G, Fagone P, Condorelli F, Nicoletti F, Malaguarnera L, Di Rosa M. CD4+ T-cell gene expression of healthy donors, HIV-1 and elite controllers: Immunological chaos. Cytokine. 2016 07; 83:127-135.

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Johnson VE, Vonderheid EC, Hess AD, Eischen CM, McGirt LY. Genetic markers associated with progression in early mycosis fungoides. J Eur Acad Dermatol Venereol. 2014 Nov; 28(11):1431-5.

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Bocian C, Urbanowitz AK, Owens RT, Iozzo RV, G?tte M, Seidler DG. Decorin potentiates interferon-? activity in a model of allergic inflammation. J Biol Chem. 2013 May 03; 288(18):12699-711.

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Loza MJ, Foster S, Bleecker ER, Peters SP, Penn RB. Asthma and gender impact accumulation of T cell subtypes. Respir Res. 2010 Jul 28; 11:103.

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Gran B, Yu S, Zhang GX, Rostami A. Accelerated thymocyte maturation in IL-12R?2-deficient mice contributes to increased susceptibility to autoimmune inflammatory demyelination. Exp Mol Pathol. 2010 Oct; 89(2):126-34.

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Lagouros E, Salomao D, Thorland E, Hodge DO, Vile R, Pulido JS. Infiltrative T regulatory cells in enucleated uveal melanomas. Trans Am Ophthalmol Soc. 2009 Dec; 107:223-8.

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