Alternative Splicing

"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

Descriptor ID	D017398
MeSH Number(s)	G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
Concept/Terms	Alternative Splicing Alternative Splicing Alternative Splicings Splicings, Alternative Alternate Splicing Alternate Splicings Splicing, Alternate Splicings, Alternate RNA Splicing, Alternative Alternative RNA Splicing Alternative RNA Splicings RNA Splicings, Alternative Splicing, Alternative RNA Splicings, Alternative RNA Splicing, Alternative Nested Transcripts Nested Transcripts Nested Transcript Transcript, Nested Transcripts, Nested

Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
RNA Processing, Post-Transcriptional [G02.111.760]
RNA Splicing [G02.111.760.700]
Alternative Splicing [G02.111.760.700.100]
Metabolism [G03]
RNA Processing, Post-Transcriptional [G03.839]
RNA Splicing [G03.839.700]
Alternative Splicing [G03.839.700.100]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
RNA Processing, Post-Transcriptional [G05.308.700]
RNA Splicing [G05.308.700.700]
Alternative Splicing [G05.308.700.700.100]

Below are MeSH descriptors whose meaning is related to "Alternative Splicing".

Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.

Bar chart showing 75 publications over 25 distinct years, with a maximum of 8 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	2	2	4
1996	0	1	1
1997	1	1	2
1998	0	1	1
1999	1	0	1
2001	0	1	1
2002	7	1	8
2003	0	4	4
2004	2	1	3
2005	1	6	7
2006	2	4	6
2007	5	1	6
2008	1	3	4
2009	1	1	2
2010	4	1	5
2011	2	0	2
2012	0	1	1
2013	0	4	4
2014	1	1	2
2015	0	2	2
2016	0	2	2
2017	1	0	1
2019	2	2	4
2020	0	1	1
2022	0	1	1

Below are the most recent publications written about "Alternative Splicing" by people in Profiles.

Pan Y, Phillips JW, Zhang BD, Noguchi M, Kutschera E, McLaughlin J, Nesterenko PA, Mao Z, Bangayan NJ, Wang R, Tran W, Yang HT, Wang Y, Xu Y, Obusan MB, Cheng D, Lee AH, Kadash-Edmondson KE, Champhekar A, Puig-Saus C, Ribas A, Prins RM, Seet CS, Crooks GM, Witte ON, Xing Y. IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing. Proc Natl Acad Sci U S A. 2023 May 23; 120(21):e2221116120.

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Kanda S, Moulton E, Butchbach MER. Effects of Inhibitors of SLC9A-Type Sodium-Proton Exchangers on Survival Motor Neuron 2 (SMN2) mRNA Splicing and Expression. Mol Pharmacol. 2022 08; 102(2):92-105.

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Itskovich SS, Gurunathan A, Clark J, Burwinkel M, Wunderlich M, Berger MR, Kulkarni A, Chetal K, Venkatasubramanian M, Salomonis N, Kumar AR, Lee LH. MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia. Nat Commun. 2020 05 12; 11(1):2369.

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Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ. Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. Elife. 2019 09 03; 8.

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Y?ksel Z, Vogel F, Alhashem AM, Alanzi TSA, Tabarki B, Kampe K, Kandaswamy KK, Werber M, Bertoli-Avella AM, Beetz C, Rolfs A, Bauer P. A homozygous frameshift variant in an alternatively spliced exon of DLG5 causes hydrocephalus and renal dysplasia. Clin Genet. 2019 05; 95(5):631-633.

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Pyfrom SC, Luo H, Payton JE. PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities. BMC Genomics. 2019 Feb 15; 20(1):137.

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Lo W, Zhu B, Sabesan A, Wu HH, Powers A, Sorber RA, Ravichandran S, Chen I, McDuffie LA, Quadri HS, Beane JD, Calzone K, Miettinen MM, Hewitt SM, Koh C, Heller T, Wacholder S, Rudloff U. Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC). J Med Genet. 2019 06; 56(6):370-379.

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Shemesh A, Brusilovsky M, Kundu K, Ottolenghi A, Campbell KS, Porgador A. Splice variants of human natural cytotoxicity receptors: novel innate immune checkpoints. Cancer Immunol Immunother. 2018 Dec; 67(12):1871-1883.

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Hsu CK, Liu L, Can PK, Kocat?rk E, McMillan JR, G?ng?r S, H?rdogan ?, Sargan A, Degirmentepe EN, Lee JY, Simpson MA, McGrath JA. Ectodermal dysplasia-skin fragility syndrome resulting from a new atypical homozygous cryptic acceptor splice site mutation in PKP1. J Dermatol Sci. 2016 Nov; 84(2):210-212.

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Wang Y, Bernhardy AJ, Cruz C, Krais JJ, Nacson J, Nicolas E, Peri S, van der Gulden H, van der Heijden I, O'Brien SW, Zhang Y, Harrell MI, Johnson SF, Candido Dos Reis FJ, Pharoah PD, Karlan B, Gourley C, Lambrechts D, Chenevix-Trench G, Olsson H, Benitez JJ, Greene MH, Gore M, Nussbaum R, Sadetzki S, Gayther SA, Kjaer SK, D'Andrea AD, Shapiro GI, Wiest DL, Connolly DC, Daly MB, Swisher EM, Bouwman P, Jonkers J, Balma?a J, Serra V, Johnson N. The BRCA1-?11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin. Cancer Res. 2016 05 01; 76(9):2778-90.

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